Neuroprotective potential of Celastrus paniculatus seeds against common neurological ailments: a narrative review
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Divya Sankaramourthy
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Lakshmi Sankaranarayanan
,
Kavimani Subramanian
und
Sudha Rani Sadras
Abstract
The most common human neurodegenerative diseases like Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD) etc. have been recognized to result from a complex interplay between genetic predisposition and defective cellular dynamics such as inappropriate accumulation of unfolded proteins, oxygen free radicals and mitochondrial dysfunction. The treatment strategies available today for these neurodegenerative ailments are only palliative and are incapable of restraining the progression of the disease. Hence, there is an immense requirement for identification of drug candidates with the ability to alleviate neuronal damage along with controlling progression of the disease. From time immemorial mankind has been relying on plants for treating varied types of dreadful diseases. Among the various medicinal plants used for treating various neurological ailments, Celastrus paniculatus (CP) popularly known as Jyotishmati or Malkangni is well known in the Ayurveda system of Indian Traditional Medicine whose seeds and seed oil have been used for centuries in treating epilepsy, dementia, facial paralysis, amnesia, anxiety, sciatica, cognitive dysfunctions etc. This review apart from specifying the phytochemical characteristics and traditional uses of C. paniculatus seeds and seed oil also exemplify the comprehensive data derived from various research reports on their therapeutic potential against some common neurological disorders.
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Research funding: No funding has been involved.
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Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission. All authors have contributed equally to the conception of topic, interpretation and correlation of available literature evidence for the preparation of this review article.
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Competing interests: All authors manifest that there are no conflict of interests.
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Informed consent: Not applicable.
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Ethical approval: Not applicable (no human participants, human data or human tissue involved).
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© 2022 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Reviews
- The effect of lavender on mothers sleep quality in the postpartum period: a systematic review and meta-analysis
- The effect of Salvia officinalis on blood glycemic indexes and blood lipid profile in diabetic patients: a systematic review and meta-analysis
- Neuroprotective potential of Celastrus paniculatus seeds against common neurological ailments: a narrative review
- Intuitive and mindful eating to improve physiological health parameters: a short narrative review of intervention studies
- Research Articles
- Vitamin C supplementation modulates crude oil contaminated water induced gravid uterine impaired contractile mechanism and foetal outcomes in Wistar rats
- Acute and sub acute toxicity of Amirdha Gandhi Kukkil Vallathy an effective Siddha herbo mineral formulation used in the treatment of rheumatoid arthritis in wistar albino rat model
- Anti-hyperplastic effects of the Dacryodes edulis (Burseraceae) leaves aqueous extract on tamoxifen-induced endometrium hyperplasia on Wistar rat
- Vitamin A and vitamin D3 protect the visual apparatus during the development of dopamine-2 receptor knockout mouse model of Parkinsonism
- Leaf paste of Telfairia occidentalis favourably modulates deleterious effects associated with exposure to diethylnitrosamine in male Wistar rats
- Chemical composition, antioxidant, and enzyme inhibitory properties of Rauwolfia vomitoria extract
- Intra-stromal injection of honey-treated keratocytes as a cell-based therapy for experimental corneal laceration
- Effect of Annona squamosa leaf extract on human promyelocytic leukemia cells subjected to oxidative stress
- Cinnamic acids as promising bioactive compounds for cancer therapy by targeting MAPK3: a computational simulation study
- Cowanin induces apoptosis in breast cancer cells via Bcl-2 signaling pathway
- Arq Ajīb – a wonder Unani formulation for inhibiting SARS-CoV-2 spike glycoprotein and main protease – an in silico approach
- Immediate effect of a meditation technique on blood glucose, state anxiety and relaxation in patients with type 2 diabetes: a pilot randomized crossover study
- Effect of moderate intensity resistance training with blood flow restriction on muscle strength and girth in young adults – a randomized control trial
- Short Communication
- Icosapent ethyl (VASCEPA®) as treatment for post-acute sequelae of SARS CoV-2 (PASC) vaccine induced injury and infection
Artikel in diesem Heft
- Frontmatter
- Reviews
- The effect of lavender on mothers sleep quality in the postpartum period: a systematic review and meta-analysis
- The effect of Salvia officinalis on blood glycemic indexes and blood lipid profile in diabetic patients: a systematic review and meta-analysis
- Neuroprotective potential of Celastrus paniculatus seeds against common neurological ailments: a narrative review
- Intuitive and mindful eating to improve physiological health parameters: a short narrative review of intervention studies
- Research Articles
- Vitamin C supplementation modulates crude oil contaminated water induced gravid uterine impaired contractile mechanism and foetal outcomes in Wistar rats
- Acute and sub acute toxicity of Amirdha Gandhi Kukkil Vallathy an effective Siddha herbo mineral formulation used in the treatment of rheumatoid arthritis in wistar albino rat model
- Anti-hyperplastic effects of the Dacryodes edulis (Burseraceae) leaves aqueous extract on tamoxifen-induced endometrium hyperplasia on Wistar rat
- Vitamin A and vitamin D3 protect the visual apparatus during the development of dopamine-2 receptor knockout mouse model of Parkinsonism
- Leaf paste of Telfairia occidentalis favourably modulates deleterious effects associated with exposure to diethylnitrosamine in male Wistar rats
- Chemical composition, antioxidant, and enzyme inhibitory properties of Rauwolfia vomitoria extract
- Intra-stromal injection of honey-treated keratocytes as a cell-based therapy for experimental corneal laceration
- Effect of Annona squamosa leaf extract on human promyelocytic leukemia cells subjected to oxidative stress
- Cinnamic acids as promising bioactive compounds for cancer therapy by targeting MAPK3: a computational simulation study
- Cowanin induces apoptosis in breast cancer cells via Bcl-2 signaling pathway
- Arq Ajīb – a wonder Unani formulation for inhibiting SARS-CoV-2 spike glycoprotein and main protease – an in silico approach
- Immediate effect of a meditation technique on blood glucose, state anxiety and relaxation in patients with type 2 diabetes: a pilot randomized crossover study
- Effect of moderate intensity resistance training with blood flow restriction on muscle strength and girth in young adults – a randomized control trial
- Short Communication
- Icosapent ethyl (VASCEPA®) as treatment for post-acute sequelae of SARS CoV-2 (PASC) vaccine induced injury and infection
