Startseite Could Anise decrease the intensity of premenstrual syndrome symptoms in comparison to placebo? A double-blind randomized clinical trial
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Could Anise decrease the intensity of premenstrual syndrome symptoms in comparison to placebo? A double-blind randomized clinical trial

  • Maryam Farahmand , Davood Khalili , Fahimeh Ramezani Tehrani , Gholamreza Amin und Reza Negarandeh ORCID logo EMAIL logo
Veröffentlicht/Copyright: 25. Dezember 2020

Abstract

Background

Premenstrual syndrome (PMS) has a high prevalence among women of reproductive ages but despite its high prevalence, it has no determined and absolute treatment, so far. So, the aim of the present study was to compare the effect Pimpinella Anisum (Anise) with placebo on the intensity of the symptoms of PMS.

Methods

The present study was a randomized double-blind controlled clinical trial. College students who were suffering from PMS and had the inclusion criteria were selected and randomly assigned into two groups of intervention (Anise) and control (placebo). Participants in the intervention group, received 110 mg capsules of Anise three times day (a total dose of 330 mg per day); the control group received similar capsules with the same dosing that contained starch. Consumption of the capsules was started 7 days before the start of the menstruation and continued until 3 days after, which was a total of 10 days during two consecutive menstruation cycles. The intensity of the symptoms of premenstrual syndrome was measured using Premenstrual Symptoms Screening Tool (PSST). To compare the intensity of the symptoms between the two study groups, generalized estimating equation statistical method was used.

Results

Eventually, sixty-seven 18–35 year old college students who were suffering from premenstrual syndrome were enrolled in the study. Comparing the mean score of the intensity of the syndrome between the two groups after the first and the second menstruation cycles showed a decrease in the intervention group to 13.9 (p-value<0.001; 95% CI: 16.5,−11.4) and 9.8 (p-value<0.001; 95% CI: 12.4,−7.3), respectively.

Conclusion

Results of the study showed that, in general, Anise was effective in decreasing the symptoms of premenstrual syndrome in comparison to placebo.

Acknowledgments

This research has been supported by Tehran University of Medical Sciences & health Services grant 94-01-99-28715. The authors would like to thank the participants for their contributions to this study. The authors wish to acknowledge R. Abdolmaleki for sampling and data gathering.

  1. Authors contributions: MF conceptualized and designed the study, analyzed and interpreted the data, and drafting and revising the manuscript. DK and FRT conceptualized and designed the study, participated in analyzed and interpretation of the data, and revised the manuscript. GA participated in designing the study and preparation of intervention materials. RN designed the study, and drafting and revising the manuscript.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2019-03-17
Accepted: 2020-01-12
Published Online: 2020-12-25

© 2020 Walter de Gruyter GmbH, Berlin/Boston

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