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Point-of-care testing: revolutionizing clinical biochemistry using decentralized diagnostics

  • Simran Shaikh ORCID logo , Sanjyoti A. Panchbudhe ORCID logo , Rajni R. Shivkar ORCID logo , Arnab Banerjee ORCID logo , Paulami Deshmukh ORCID logo und Charushila Y. Kadam ORCID logo EMAIL logo
Veröffentlicht/Copyright: 4. April 2025
Journal of Basic and Clinical Physiology and Pharmacology
Aus der Zeitschrift Journal of Basic and Clinical Physiology and Pharmacology Band 36 Heft 2-3

Abstract

Point-of-care testing (POCT) refers to decentralized testing done using complex but compact, portable devices that can be done near the site at the patient’s bedside. These enable quick diagnosis and timely intervention because turnaround time (TAT) decreases with these devices. They can also be operated by non-medical personnel and patients with minimum expertise as these devices are easy to handle and interpret. This increases patient awareness regarding their diseases and benefits doctors in giving more patient-centered care. POCT devices require minimum setup and can be utilized even in remote places. The present review focuses on POCT devices employed specifically in clinical biochemistry, e.g., glucose, HbA1c, cardiac biomarkers, fertility tests, hematological analysis, electrolytes, enzymes, urine dipstick tests, etc. This introductory review delves into comprehending the fundamentals of POCT technologies, their guidelines, applications, advantages, and disadvantages. It covers a broad overview of the tests done and the samples required to process these tests. It also compares the pros and cons of POCT devices over centralized laboratory testing. The review also aims to emphasize the relevance of its use in today’s era, current trends regarding POCT in urban and rural setups, challenges faced in the field during its implementation, and the potential areas of improvement in the future. However, it is advisable to seek references for more detailed and critical information regarding all the specific topics given in this review article.

Keywords: point-of-care testing; clinical biochemistry; critical care; evidence-based medicine; healthcare transformation
Corresponding author: Charushila Y. Kadam, Professor, Department of Biochemistry, Sukh Sagar Medical College and Hospital, Jabalpur, 482003, Madhya Pradesh, India, E-mail:

Acknowledgments

The authors would like to acknowledge administrative support from the Department of Biochemistry, Smt. Kashibai Navale Medical College and General Hospital (Narhe, Pune-411041, Maharashtra, India), Department of Physiology (UG & PG), Serampore College (9, William Carey Road, Serampore, Hooghly-712201, West Bengal, India), and Department of Biochemistry, Sukh Sagar Medical College and Hospital (Jabalpur-482003, Madhya Pradesh, India). Figure 2 was drawn using the BioRender.com online tool.

  1. Research ethics: Not applicable.

  2. Informed consent: Not applicable.

  3. Author contributions: All authors have affirmed their submission and accepted responsibility for the whole content of this submitted work. S.S. and S.A.P. were responsible for the concept, writing the original draft, and reviewing it for confirmation of submission. R.R.S., A.B., and P.D. were equally responsible for writing the original draft, formal analysis, and finally reviewing the final draft of the manuscript. C.Y.K. was responsible for the concept, writing and reviewing the original draft, and final approval for submission of the manuscript.

  4. Use of Large Language Models, AI and Machine Learning Tools: None declared.

  5. Conflict of interest: The authors state no conflict of interest.

  6. Research funding: None declared.

  7. Data availability: Not applicable.

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Received: 2025-01-31
Accepted: 2025-03-13
Published Online: 2025-04-04

© 2025 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
  3. Navigating nephropathy and nephrotoxicity: understanding pathophysiology unveiling clinical manifestations, and exploring treatment approaches
  4. Incretin-based therapies: advancements, challenges, and future directions in type 2 diabetes management
  5. Point-of-care testing: revolutionizing clinical biochemistry using decentralized diagnostics
  6. The impact of heavy metals exposure on male fertility: a scoping review of human studies
  7. Glucagon in glucose homeostasis and metabolic disease: from physiology to therapeutics
  8. The efficacy of dietary supplements on health status and performance of football players: a systematic review
  9. Original Articles
  10. Factors affecting self-care in heart failure patients: a cross-sectional study
  11. Physiological regulation of moderate-intensity exercise in improving the biomarkers visfatin and myonectin as a modulator of increasing metabolic performance in obese
  12. A comparative study of heart rate variability (HRV) among adult hypertensive and normotensive subjects in the supine position
  13. Elevated seminal plasma leptin may correlate with varicocele presence and BMI
  14. Clinical significance of detectable blood lead and cadmium in the Sarno river basin population: results from the PREVES-STOP study
  15. Outcomes of systemic thrombolysis with reteplase in high-risk acute pulmonary embolism
  16. The pharmacokinetics and comparative bioavailabilty of oral and subcutaneous semaglutide in healthy volunteers
  17. Short Communications
  18. Approaching a phenomenal contradiction in acid–base physiology
  19. Current trends and innovations in oral and maxillofacial surgery
  20. Letter to the Editor
  21. The need for quality certification for urological apps
https://doi.org/10.1515/jbcpp-2025-0029
Schlagwörter für diesen Artikel
point-of-care testing; clinical biochemistry; critical care; evidence-based medicine; healthcare transformation

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
  3. Navigating nephropathy and nephrotoxicity: understanding pathophysiology unveiling clinical manifestations, and exploring treatment approaches
  4. Incretin-based therapies: advancements, challenges, and future directions in type 2 diabetes management
  5. Point-of-care testing: revolutionizing clinical biochemistry using decentralized diagnostics
  6. The impact of heavy metals exposure on male fertility: a scoping review of human studies
  7. Glucagon in glucose homeostasis and metabolic disease: from physiology to therapeutics
  8. The efficacy of dietary supplements on health status and performance of football players: a systematic review
  9. Original Articles
  10. Factors affecting self-care in heart failure patients: a cross-sectional study
  11. Physiological regulation of moderate-intensity exercise in improving the biomarkers visfatin and myonectin as a modulator of increasing metabolic performance in obese
  12. A comparative study of heart rate variability (HRV) among adult hypertensive and normotensive subjects in the supine position
  13. Elevated seminal plasma leptin may correlate with varicocele presence and BMI
  14. Clinical significance of detectable blood lead and cadmium in the Sarno river basin population: results from the PREVES-STOP study
  15. Outcomes of systemic thrombolysis with reteplase in high-risk acute pulmonary embolism
  16. The pharmacokinetics and comparative bioavailabilty of oral and subcutaneous semaglutide in healthy volunteers
  17. Short Communications
  18. Approaching a phenomenal contradiction in acid–base physiology
  19. Current trends and innovations in oral and maxillofacial surgery
  20. Letter to the Editor
  21. The need for quality certification for urological apps
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