Physiological regulation of moderate-intensity exercise in improving the biomarkers visfatin and myonectin as a modulator of increasing metabolic performance in obese
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Sugiharto
,
Adi Pranoto
Abstract
Objectives
A well-structured, regular, and programmed physical exercise regimen is believed to be an effective physiological modulator for preventing the dysfunction of myonectin and visfatin secretion. Therefore, this study aims to analyze the physiological regulation of moderate-intensity programmed exercise in improving myonectin and visfatin biomarkers in obese women.
Methods
The study involved 30 physically healthy obese women, nonathletes, selected based on predetermined criteria, who voluntarily agreed to participate. They were then divided into two groups: a control group (CRT; n=15) and a programmed exercise group (ART; n=15). The exercise program lasted for 8 weeks, with a frequency of 5 times per week at moderate intensity. Metabolic performance was analyzed using the myonectin and visfatin biomarkers with the Sandwich-ELISA method. Data analysis was conducted using parametric paired sample t-tests and independent sample t-tests at a 5 % significance level.
Results
The study results showed a significant increase in myonectin secretion and a decrease in visfatin secretion (p≤0.05) after 8 weeks of programmed exercise, demonstrated by an increase in myonectin of 97.85 pg/mL and a decrease in visfatin of 0.05 ng/mL. Conversely, in the control group, myonectin decreased by 3.04 pg/mL, and visfatin increased by 0.03 ng/mL.
Conclusions
These findings confirm that an 8-week programmed exercise regimen can improve the secretion of myonectin and visfatin biomarkers, thereby enhancing metabolic performance in obese women. Thus, myonectin and visfatin biomarkers induced by programmed exercise serve as modulators for enhancing metabolic performance in obese women.
Funding source: Universitas Negeri Malang
Award Identifier / Grant number: 5.4.97/UN32/KP/2024 and 5.4.43/UN32.14.1/LT/2024
Acknowledgments
The authors would like to acknowledge the Universitas Negeri Malang, Universitas Negeri Padang, Universitas Padjadjaran, for supporting this project. We would also like to express our gratitude to all the subjects who participated in this research.
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Research ethics: All procedures applied in this study have complied with the World Medical Association Declaration of Helsinki and were approved by the Ethics Committee of Universitas Negeri Malang, Indonesia, on May 30, 2024 (No. 30.5.17/UN32.14.2.8/LT/2024).
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Informed consent: Informed consent was obtained from all individuals included in this study, or their legal guardians or wards.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Use of Large Language Models, AI and Machine Learning Tools: Language translation is carried out by sworn language translation experts.
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Conflict of interest: The authors state no conflict of interest in this study.
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Research funding: This study was supported by research funds Riset Kolaborasi Indonesia (RKI) Universitas Negeri Malang with grant number: 5.4.97/UN32/KP/2024 and 5.4.43/UN32.14.1/LT/2024.
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Data availability: The raw data can be obtained on request from the corresponding author (sugiharto@um.ac.id).
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© 2025 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Reviews
- Navigating nephropathy and nephrotoxicity: understanding pathophysiology unveiling clinical manifestations, and exploring treatment approaches
- Incretin-based therapies: advancements, challenges, and future directions in type 2 diabetes management
- Point-of-care testing: revolutionizing clinical biochemistry using decentralized diagnostics
- The impact of heavy metals exposure on male fertility: a scoping review of human studies
- Glucagon in glucose homeostasis and metabolic disease: from physiology to therapeutics
- The efficacy of dietary supplements on health status and performance of football players: a systematic review
- Original Articles
- Factors affecting self-care in heart failure patients: a cross-sectional study
- Physiological regulation of moderate-intensity exercise in improving the biomarkers visfatin and myonectin as a modulator of increasing metabolic performance in obese
- A comparative study of heart rate variability (HRV) among adult hypertensive and normotensive subjects in the supine position
- Elevated seminal plasma leptin may correlate with varicocele presence and BMI
- Clinical significance of detectable blood lead and cadmium in the Sarno river basin population: results from the PREVES-STOP study
- Outcomes of systemic thrombolysis with reteplase in high-risk acute pulmonary embolism
- The pharmacokinetics and comparative bioavailabilty of oral and subcutaneous semaglutide in healthy volunteers
- Short Communications
- Approaching a phenomenal contradiction in acid–base physiology
- Current trends and innovations in oral and maxillofacial surgery
- Letter to the Editor
- The need for quality certification for urological apps
Articles in the same Issue
- Frontmatter
- Reviews
- Navigating nephropathy and nephrotoxicity: understanding pathophysiology unveiling clinical manifestations, and exploring treatment approaches
- Incretin-based therapies: advancements, challenges, and future directions in type 2 diabetes management
- Point-of-care testing: revolutionizing clinical biochemistry using decentralized diagnostics
- The impact of heavy metals exposure on male fertility: a scoping review of human studies
- Glucagon in glucose homeostasis and metabolic disease: from physiology to therapeutics
- The efficacy of dietary supplements on health status and performance of football players: a systematic review
- Original Articles
- Factors affecting self-care in heart failure patients: a cross-sectional study
- Physiological regulation of moderate-intensity exercise in improving the biomarkers visfatin and myonectin as a modulator of increasing metabolic performance in obese
- A comparative study of heart rate variability (HRV) among adult hypertensive and normotensive subjects in the supine position
- Elevated seminal plasma leptin may correlate with varicocele presence and BMI
- Clinical significance of detectable blood lead and cadmium in the Sarno river basin population: results from the PREVES-STOP study
- Outcomes of systemic thrombolysis with reteplase in high-risk acute pulmonary embolism
- The pharmacokinetics and comparative bioavailabilty of oral and subcutaneous semaglutide in healthy volunteers
- Short Communications
- Approaching a phenomenal contradiction in acid–base physiology
- Current trends and innovations in oral and maxillofacial surgery
- Letter to the Editor
- The need for quality certification for urological apps
