Diabetic wound healing approaches: an update
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Raghuvir Keni
, Farmiza Begum , Karthik Gourishetti , Gollapalle Lakshminarayanashastry Viswanatha , Pawan Ganesh Nayak , Krishnadas Nandakumar und Rekha R Shenoy
Abstract
Diabetic wounds are of profound clinical importance. Despite immense efforts directed towards its management, it results in the development of amputations, following a diagnosis of diabetic foot. With a better understanding of the complexities of the microbalance involved in the healing process, researchers have developed advanced methods for the management of wounds as well as diagnostic tools (especially, for wound infections) to be delivered to clinics sooner. In this review, we address the newer developments that hope to drive the transition from bench to bedside in the coming decade.
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Research funding: None declared.
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Author Contribution: Conceptualization R.K.; Investigation R.K., K.G.; Original draft preparation R.K, F.B., K.G.; Review, and Editing G.L.V., K.G., P.N., R.R.S.; Image designing R.K.; Supervision K.N., R.R.S.
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Conflict of Interest: Authors declare no conflict of interest.
References
1. Ghosh, P, Valia, R. Burden of Diabetic Foot Ulcers in India: Evidence Landscape from Published Literature. Value Heal. 2017;20:A485, https://doi.org/10.1016/j.jval.2017.08.489.Suche in Google Scholar
2. Wallace, HA, Zito, PM. Wound Healing Phases. Treasure Island (FL): StatPearls Publishing; 2019.Suche in Google Scholar
3. Urao, N, Koh, TJ. Manipulating inflammation to improve healing. Wound Heal Biomater. 2016:117–50, https://doi.org/10.1016/b978-1-78242-455-0.00005-7.Suche in Google Scholar
4. Park, JE, Barbul, A. Understanding the role of immune regulation in wound healing. Am J Surg. 2004;187:S11–6, https://doi.org/10.1016/s0002-9610(03)00296-4.Suche in Google Scholar PubMed
5. Postlethwaite, AE, Keski-Oja, J, Moses, HL, Kang, AH. Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor-beta. J Exp Med. 1987;165:251–6, https://doi.org/10.1084/jem.165.1.251.Suche in Google Scholar PubMed PubMed Central
6. Li, W, Fan, J, Chen, M, Guan, S, Sawcer, D, Bokoch, GM, et al.. Mechanism of human dermal fibroblast migration driven by type I collagen and platelet-derived growth factor-BB. Mol Biol Cell. 2004;15:294–309, https://doi.org/10.1091/mbc.e03-05-0352.Suche in Google Scholar PubMed PubMed Central
7. Barrientos, S, Stojadinovic, O, Golinko, MS, Brem, H, Tomic-Canic, M. Growth factors and cytokines in wound healing. Wound Repair Regen. 2008;16:585–601, https://doi.org/10.1111/j.1524-475x.2008.00410.x.Suche in Google Scholar
8. Efron, DT, Witte, MB, Barbul, A. Wound Healing: Physiology, Clinical Progress, Growth Factors, and the Secret of the Fetus. Mult Organ Fail. 2000:553–61, https://doi.org/10.1007/978-1-4612-1222-5_56.Suche in Google Scholar
9. Pierce, GF, Mustoe, TA, Altrock, BW, Deuel, TF, Thomason, A. Role of platelet‐derived growth factor in wound healing. J Cell Biochem. 1991;45:319–26, https://doi.org/10.1002/jcb.240450403.Suche in Google Scholar PubMed
10. Lawrence, WT, Diegelmann, RF. Growth factors in wound healing. Clin Dermatol. 1994;12:157–69, https://doi.org/10.1016/0738-081x(94)90266-6.Suche in Google Scholar PubMed
11. Gabbiani, G, Ryan, GB, Majno, G. Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia. 1971;27:549–50, https://doi.org/10.1007/bf02147594.Suche in Google Scholar
12. Ud‐Din, S, Bayat, A. Keloid scarring or disease: Unresolved quasi‐neoplastic tendencies in the human skin. Wound Repair Regen. 2020;28:42–6.10.1111/wrr.12793Suche in Google Scholar PubMed
13. Pastar, I, Stojadinovic, O, Yin, NC, Ramirez, H, Nusbaum, AG, Sawaya, A, et al.. Epithelialization in wound healing: a comprehensive review. Adv Wound Care. 2014;3:445–64, https://doi.org/10.1089/wound.2013.0473.Suche in Google Scholar PubMed PubMed Central
14. Broughton, G, Janis, JE, Attinger, CE. The basic science of wound healing. Plast Reconstr Surg. 2006;117:12S–34S, https://doi.org/10.1097/01.prs.0000225430.42531.c2.Suche in Google Scholar PubMed
15. Margolis, DJ, Hofstad, O, Feldman, HI. Association between renal failure and foot ulcer or lower-extremity amputation in patients with diabetes. Diabetes Care. 2008;31:1331–6, https://doi.org/10.2337/dc07-2244.Suche in Google Scholar PubMed PubMed Central
16. Ritz, E, Schömig, M, Schöomig, S, Standl, E, Allenberg, J. The diabetic foot in the dialyzed patient. J Am Soc Nephrol. 2000;11:1153–59, https://doi.org/10.1681/ASN.V1161153.Suche in Google Scholar PubMed
17. Pinto, A, Tuttolomondo, A, Di Raimondo, D, Fernandez, P, La Placa, S, Di Gati, M, et al.. Cardiovascular risk profile and morbidity in subjects affected by type 2 diabetes mellitus with and without diabetic foot. Metabolism. 2008;57:676–82, https://doi.org/10.1016/j.metabol.2008.01.004.Suche in Google Scholar PubMed
18. Weiss, N A critical review on the use of lipid apheresis and rheopheresis for treatment of peripheral arterial disease and the diabetic foot syndrome. Semin Dial. 2012;25:220–7, https://doi.org/10.1111/j.1525-139x.2011.01036.x.Suche in Google Scholar PubMed
19. Wagner, FW. The diabetic foot. Orthopedics. 1987;10:163–72, https://doi.org/10.3928/0147-7447-19870101-28.Suche in Google Scholar PubMed
20. Bakker, K, Apelqvist, J, Lipsky, BA, Van Netten, JJ, Schaper, NC. The 2015 IWGDF guidance documents on prevention and management of foot problems in diabetes: development of an evidence-based global consensus. Diabetes Metab Res Rev. 2016;32:2–6, https://doi.org/10.1002/dmrr.2694.Suche in Google Scholar PubMed
21. Wong, SL, Demers, M, Martinod, K, Gallant, M, Wang, Y, Goldfine, AB, et al.. Diabetes primes neutrophils to undergo NETosis, which impairs wound healing. Nat Med. 2015;21:815–9, https://doi.org/10.1038/nm.3887.Suche in Google Scholar PubMed PubMed Central
22. Brem, H, Tomic-canic, M. Cellular and molecular basis of wound healing in diabetes. J Clin Invest. 2007;117:1219–22, https://doi.org/10.1172/jci32169.Suche in Google Scholar PubMed PubMed Central
23. Basu Mallik, S, Jayashree, BS, Shenoy, RR. Epigenetic modulation of macrophage polarization- perspectives in diabetic wounds. J Diabetes Complications. 2018;32:524–30, https://doi.org/10.1016/j.jdiacomp.2018.01.015.Suche in Google Scholar PubMed
24. Shaikh‐Kader, A, Houreld, NN, Rajendran, NK, Abrahamse, H. The link between advanced glycation end products and apoptosis in delayed wound healing. Cell Biochem Funct. 2019;37:432–42, https://doi.org/10.1002/cbf.3424.Suche in Google Scholar PubMed
25. Greenhalgh, DG. Wound healing and diabetes mellitus. Clin Plast Surg. 2003;30:37–45, https://doi.org/10.1016/s0094-1298(02)00066-4.Suche in Google Scholar PubMed
26. Loots, MAM, Kenter, SB, Au, FL, Van Galen, WJM, Middelkoop, E, Bos, JD, et al.. Fibroblasts derived from chronic diabetic ulcers differ in their response to stimulation with EGF, IGF-I, bFGF, and PDGF-AB compared to controls. Eur J Cell Biol. 2002;81:153–60, https://doi.org/10.1078/0171-9335-00228.Suche in Google Scholar PubMed
27. Alavi, A, Sibbald, RG, Mayer, D, Goodman, L, Botros, M, Armstrong, DG, et al.. Diabetic foot ulcers: Part I. Pathophysiology and prevention. J Am Acad Dermatol. 2014;1:e1–18, https://doi.org/10.1016/j.jaad.2013.06.055.Suche in Google Scholar PubMed
28. Younan, G, Ogawa, R, Ramirez, M, Helm, D, Dastouri, P, Orgill, DP. Analysis of nerve and neuropeptide patterns in vacuum-assisted closure–treated diabetic murine wounds. Plast Reconstr Surg. 2010;126:87–96, https://doi.org/10.1097/prs.0b013e3181da86d0.Suche in Google Scholar PubMed
29. Perez-Favila, A, Martinez-Fierro, ML, Rodriguez-Lazalde, JG, Cid-Baez, MA, Zamudio-Osuna, MDJ, Martinez-Blanco, MDR, et al.. Current therapeutic strategies in diabetic foot ulcers. Medicina. 2019;55:714, https://doi.org/10.3390/medicina55110714.Suche in Google Scholar PubMed PubMed Central
30. Volmer-Thole, M, Lobmann, R. Neuropathy and diabetic foot syndrome. Int J Mol Sci. 2016;17:917, https://doi.org/10.3390/ijms17060917.Suche in Google Scholar PubMed PubMed Central
31. Hart, CE, Loewen-Rodriguez, A, Lessem, J. Dermagraft: use in the treatment of chronic wounds. Adv Wound Care. 2012;1:138–41, https://doi.org/10.1089/wound.2011.0282.Suche in Google Scholar PubMed PubMed Central
32. Marston, WA, Hanft, J, Norwood, P, Pollak, R, Dermagraft Diabetic Foot Ulcer Study Group. The efficacy and safety of Dermagraft in improving the healing of chronic diabetic foot ulcers: results of a prospective randomized trial. Diabetes Care. 2003;26:1701–5, https://doi.org/10.2337/diacare.26.6.1701.Suche in Google Scholar PubMed
33. Kirsner, RS, Margolis, DJ, Baldursson, BT, Petursdottir, K, Davidsson, OB, Weir, D, et al.. Fish skin grafts compared to human amnion/chorion membrane allografts: A double-blind, prospective, randomized clinical trial of acute wound healing. Wound Repair Regen. 2020;28:75–80, https://doi.org/10.1111/wrr.12761.Suche in Google Scholar PubMed PubMed Central
34. Weller, C, Weller, C, Team, V. Interactive dressings and their role in moist wound management. Adv Text Wound Care. 2019:105–34, https://doi.org/10.1016/b978-0-08-102192-7.00004-7.Suche in Google Scholar
35. Dr, M, Jha, A, Kumar, M, Ajmal, G, Bonde, GV, Mishra, B. Electrospun nanofiber based drug delivery platform: Advances in diabetic foot ulcer management. Expert Opin Drug Deliv. 2021;18:25–42, https://doi.org/10.1080/17425247.2021.1823966.Suche in Google Scholar PubMed
36. Lee, CH, Hung, KC, Hsieh, MJ, Chang, SH, Juang, JH, Hsieh, IC, et al.. Core-shell insulin-loaded nanofibrous scaffolds for repairing diabetic wounds. Nanomedicine. 2020;24:102123, https://doi.org/10.1016/j.nano.2019.102123.Suche in Google Scholar PubMed
37. Ren, X, Han, Y, Wang, J, Jiang, Y, Yi, Z, Xu, H, et al.. An aligned porous electrospun fibrous membrane with controlled drug delivery – an efficient strategy to accelerate diabetic wound healing with improved angiogenesis. Acta Biomater. 2018;70:140–53, https://doi.org/10.1016/j.actbio.2018.02.010.Suche in Google Scholar PubMed
38. Xie, X, Li, D, Su, C, Cong, W, Mo, X, Hou, G, et al.. Functionalized biomimetic composite nanfibrous scaffolds with antibacterial and hemostatic efficacy for facilitating wound healing. J Biomed Nanotechnol. 2019;16:1267–79, https://doi.org/10.1166/jbn.2019.2756.Suche in Google Scholar PubMed
39. Weller, CD, Team, V, Sussman, G. First-line interactive wound dressing update: a comprehensive review of the evidence. Front Pharmacol. 2020;11:155, https://doi.org/10.3389/fphar.2020.00155.Suche in Google Scholar PubMed PubMed Central
40. Bowlby, M, Blume, P, Schmidt, B, Donegan, R. Safety and efficacy of Becaplermin gel in the treatment of diabetic foot ulcers. Chronic Wound Care Manag Res. 2014;1:11–14, https://doi.org/10.2147/cwcmr.s64905.Suche in Google Scholar
41. Diabetic ulcer gel gets black box warning [Internet]. Medscape. 2022 [cited 1 January 2022]. Available from: https://www.medscape.com/viewarticle/575748.Suche in Google Scholar
42. Merrell, JG, McLaughlin, SW, Tie, L, Laurencin, CT, Chen, AF, Nair, LS. Curcumin-loaded poly(ε-caprolactone) nanofibres: Diabetic wound dressing with anti-oxidant and anti-inflammatory properties. Clin Exp Pharmacol Physiol. 2009;36:1149–56, https://doi.org/10.1111/j.1440-1681.2009.05216.x.Suche in Google Scholar PubMed PubMed Central
43. Singla, R, Soni, S, Patial, V, Kulurkar, PM, Kumari, A, Mahesh, S, et al.. Cytocompatible anti-microbial dressings of syzygium cumini cellulose nanocrystals decorated with silver nanoparticles accelerate acute and diabetic wound healing. Sci Rep. 2017;7:10457, https://doi.org/10.1038/s41598-017-08897-9.Suche in Google Scholar PubMed PubMed Central
44. Kandhare, AD, Ghosh, P, Bodhankar, SL. Naringin, a flavanone glycoside, promotes angiogenesis and inhibits endothelial apoptosis through modulation of inflammatory and growth factor expression in diabetic foot ulcer in rats. Chem Biol Interact. 2014;219:101–12, https://doi.org/10.1016/j.cbi.2014.05.012.Suche in Google Scholar PubMed
45. Nicholas, MN, Yeung, J. Current status and future of skin substitutes for chronic wound healing. J Cutan Med Surg. 2017;21:23–30.10.1177/1203475416664037Suche in Google Scholar PubMed
46. Lopes, L, Setia, O, Aurshina, A, Liu, S, Hu, H, Isaji, T, et al.. Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research. Stem Cell Res Ther. 2018;9:188.10.1186/s13287-018-0938-6Suche in Google Scholar PubMed PubMed Central
47. Chen, S, Quan, Y, Yu, YL, Wang, JH. Graphene quantum dot/silver nanoparticle hybrids with oxidase activities for antibacterial application. ACS Biomater Sci Eng. 2017;3:313–21.10.1021/acsbiomaterials.6b00644Suche in Google Scholar PubMed
48. Li, YJ, Harroun, SG, Su, YC, Huang, CF, Unnikrishnan, B, Lin, HJ, et al.. Synthesis of self-assembled spermidine-carbon quantum dots effective against multidrug-resistant bacteria. Adv Healthc Mater. 2016;5:2545–54.10.1002/adhm.201600297Suche in Google Scholar PubMed
49. Boomi, P, Ganesan, R, Prabu Poorani, G, Jegatheeswaran, S, Balakumar, C, Gurumallesh Prabu, H, et al.. Phyto-engineered gold nanoparticles (aunps) with potential antibacterial, antioxidant, and wound healing activities under in vitro and in vivo conditions. Int J Nanomedicine. 2020;15:7553–68.10.2147/IJN.S257499Suche in Google Scholar PubMed PubMed Central
50. Turnbaugh, PJ, Ley, RE, Hamady, M, Fraser-Liggett, CM, Knight, R, Gordon, JI. The human microbiome project. Nature. 2007;449:804–10.10.1038/nature06244Suche in Google Scholar PubMed PubMed Central
51. Long, J, Cai, Q, Steinwandel, M, Hargreaves, MK, Bordenstein, SR, Blot, WJ, et al.. Association of oral microbiome with type 2 diabetes risk. J Periodontal Res. 2017;52:636–43.10.1111/jre.12432Suche in Google Scholar PubMed PubMed Central
52. Chen, B, Wang, Z, Wang, J, Su, X, Yang, J, Zhang, Q, et al.. The oral microbiome profile and biomarker in Chinese type 2 diabetes mellitus patients. Endocrine. 2020;68:564–72.10.1007/s12020-020-02269-6Suche in Google Scholar PubMed
53. Ong, JS, Taylor, TD, Yong, CC, Khoo, BY, Sasidharan, S, Choi, SB, et al.. Lactobacillus plantarum USM8613 aids in wound healing and Suppresses Staphylococcus aureus infection at wound sites. Probiotics Antimicrob Proteins. 2020;12:125–37.10.1007/s12602-018-9505-9Suche in Google Scholar PubMed
54. Kim, JH, Ruegger, PR, Lebig, EG, VanSchalkwyk, S, Jeske, DR, Hsiao, A, et al.. High levels of oxidative stress create a microenvironment that significantly decreases the diversity of the microbiota in diabetic chronic wounds and promotes biofilm formation. Front Cell Infect Microbiol. 2020;10:259.10.3389/fcimb.2020.00259Suche in Google Scholar PubMed PubMed Central
55. Hernandez, R. The use of systemic antibiotics in the treatment of chronic wounds. Dermatol Ther. 2006;19:326–37.10.1111/j.1529-8019.2006.00091.xSuche in Google Scholar PubMed
56. Lipsky, BA, Berendt, AR. Principles and practice of antibiotic therapy of diabetic foot infections. Diabetes Metab Res Rev. 2000;16:S42–6.10.1002/1520-7560(200009/10)16:1+<::AID-DMRR109>3.0.CO;2-BSuche in Google Scholar
57. Kalan, LR, Meisel, JS, Loesche, MA, Horwinski, J, Soaita, I, Chen, X, et al.. Strain- and species-level variation in the microbiome of diabetic wounds is associated with clinical outcomes and therapeutic efficacy. Cell Host Microbe. 2019;25:641–55.10.1016/j.chom.2019.03.006Suche in Google Scholar
58. Ogba, OM, Nsan, E, Eyam, ES. Aerobic bacteria associated with diabetic foot ulcers and their susceptibility pattern. Biomed Dermatol; 2019;3:1–6.10.1186/s41702-019-0039-xSuche in Google Scholar
59. Yue, H, He, Y, Fan, E, Wang, L, Lu, S, Fu, Z. Label-free electrochemiluminescent biosensor for rapid and sensitive detection of pseudomonas aeruginosa using phage as highly specific recognition agent. Biosens Bioelectron; 2017;94:429–32.10.1016/j.bios.2017.03.033Suche in Google Scholar
60. Brown, MS, Ashley, B, Koh, A. Wearable technology for chronic wound monitoring: current dressings, advancements, and future prospects. Front Bioeng Biotechnol. 2018;6:1–21.10.3389/fbioe.2018.00047Suche in Google Scholar
61. Lim, J, Choi, J, Guk, K, Son, SU, Lee, DK, Yeom, SJ, et al.. Peptidoglycan binding protein (PGBP)-modified magnetic nanobeads for efficient magnetic capturing of Staphylococcus aureus associated with sepsis in blood. Sci Rep. 2019;9:1–7.10.1038/s41598-018-37194-2Suche in Google Scholar
62. S GARY, Alhogail, S, Zourob, M. Rapid and low-cost biosensor for the detection of Staphylococcus aureus. Biosens Bioelectron; 2017;90:230–7.10.1016/j.bios.2016.11.047Suche in Google Scholar
63. Costantini, E, Sinjari, B, D’Angelo, C, Murmura, G, Reale, M, Caputi, S. Human gingival fibroblasts exposed to extremely low-frequency electromagnetic fields: in vitro model of wound-healing improvement. Int J Mol Sci. 2019;20:2108.10.3390/ijms20092108Suche in Google Scholar PubMed PubMed Central
64. Stratmann, B, Costea, TC, Nolte, C, Hiller, J, Schmidt, J, Reindel, J, et al.. Effect of cold atmospheric plasma therapy vs standard therapy placebo on wound healing in patients with diabetic foot ulcers: a randomized clinical trial. JAMA Netw open. 2020;3:e2010411.10.1001/jamanetworkopen.2020.10411Suche in Google Scholar PubMed PubMed Central
65. Fathollah, S, Mirpour, S, Mansouri, P, Dehpour, AR, Ghoranneviss, M, Rahimi, N, et al.. Investigation on the effects of the atmospheric pressure plasma on wound healing in diabetic rats. Sci Rep. Nature2016;6:1–9.10.1038/srep19144Suche in Google Scholar PubMed PubMed Central
66. Mohd Nasir, N, Lee, BK, Yap, SS, Thong, KL, Yap, SL. Cold plasma inactivation of chronic wound bacteria. Arch Biochem Biophys. 2016;605:76–85.10.1016/j.abb.2016.03.033Suche in Google Scholar PubMed
67. Kang, SM, Cho, H, Jeon, D, Park, SH, Shin, DS, Heo, CY. A matrix metalloproteinase sensing biosensor for the evaluation of chronic wounds. Biochip J. 2019;13:323–32.10.1007/s13206-019-3403-4Suche in Google Scholar
68. Gianino, E, Miller, C, Gilmore, J. Smart wound dressings for diabetic chronic wounds. Bioengineering. 2018;5:51.10.3390/bioengineering5030051Suche in Google Scholar PubMed PubMed Central
69. Nixon, M, Moore, C. White paper a three-dimensional approach to measuring, imaging and documenting wounds evidence-based wound surveillance [Internet]. Aranzmedical.com. 2016 [cited 4 January 2022]. Available from: https://www.aranzmedical.com/wp-content/uploads/ARANZ-Medical_WP_Evidence-Based-Wound-Surveillance_201608_A4.pdf.Suche in Google Scholar
70. RoyChoudhury, S, Umasankar, Y, Jaller, J, Herskovitz, I, Mervis, J, Darwin, E, et al.. Continuous monitoring of wound healing using a wearable enzymatic uric acid biosensor. J Electrochem Soc. 2018;165:B3168–75.10.1149/2.0231808jesSuche in Google Scholar
© 2021 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Editorial
- The clinical potential of flavonoids in Peyronie’s disease
- Reviews
- Emphasizing roles of BDNF promoters and inducers in Alzheimer's disease for improving impaired cognition and memory
- Diabetic wound healing approaches: an update
- Metformin: new applications for an old drug
- Bispecific antibodies and its applications: a novel approach for targeting SARS-Cov-2
- A review on pulmonary and mediastinal synovial sarcoma
- Original Articles
- Cytokine release by human bone marrow stromal cells isolated from osteoarthritic and diabetic osteoarthritic patients in vitro
- Antioxidant and anti-inflammatory effect of olive leaf extract treatment in diabetic rat brain
- Implication of nitrergic system in the anticonvulsant effects of ferulic acid in pentylenetetrazole-induced seizures in male mice
- The effects of G protein-coupled receptor 30 (GPR30) on cardiac glucose metabolism in diabetic ovariectomized female rats
- Effects of weight-bearing vs. non-weight-bearing endurance exercise on reducing body fat and inflammatory markers in obese females
- [Lys5,MeLeu9,Nle10]-NKA(4–10) induces neurokinin 2 receptor mediated urination and defecation and neurokinin 1 receptor mediated flushing in rats: measured using the rapid detection voiding assay
- Single 30 min treadmill exercise session suppresses the production of pro-inflammatory cytokines and oxidative stress in obese female adolescents
- Letter to the Editor
- Effect of tirzepatide on prediabetics and blood pressure with implications for future research
Artikel in diesem Heft
- Frontmatter
- Editorial
- The clinical potential of flavonoids in Peyronie’s disease
- Reviews
- Emphasizing roles of BDNF promoters and inducers in Alzheimer's disease for improving impaired cognition and memory
- Diabetic wound healing approaches: an update
- Metformin: new applications for an old drug
- Bispecific antibodies and its applications: a novel approach for targeting SARS-Cov-2
- A review on pulmonary and mediastinal synovial sarcoma
- Original Articles
- Cytokine release by human bone marrow stromal cells isolated from osteoarthritic and diabetic osteoarthritic patients in vitro
- Antioxidant and anti-inflammatory effect of olive leaf extract treatment in diabetic rat brain
- Implication of nitrergic system in the anticonvulsant effects of ferulic acid in pentylenetetrazole-induced seizures in male mice
- The effects of G protein-coupled receptor 30 (GPR30) on cardiac glucose metabolism in diabetic ovariectomized female rats
- Effects of weight-bearing vs. non-weight-bearing endurance exercise on reducing body fat and inflammatory markers in obese females
- [Lys5,MeLeu9,Nle10]-NKA(4–10) induces neurokinin 2 receptor mediated urination and defecation and neurokinin 1 receptor mediated flushing in rats: measured using the rapid detection voiding assay
- Single 30 min treadmill exercise session suppresses the production of pro-inflammatory cytokines and oxidative stress in obese female adolescents
- Letter to the Editor
- Effect of tirzepatide on prediabetics and blood pressure with implications for future research