Home Medicine Single 30 min treadmill exercise session suppresses the production of pro-inflammatory cytokines and oxidative stress in obese female adolescents
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Single 30 min treadmill exercise session suppresses the production of pro-inflammatory cytokines and oxidative stress in obese female adolescents

  • Adi Pranoto , Purwo Sri Rejeki , Muhammad Miftahussurur , Hayuris Kinandita Setiawan , Ghana Firsta Yosika , Misbakhul Munir , Siti Maesaroh , Septyaningrum Putri Purwoto , Cakra Waritsu and Yoshio Yamaoka
Published/Copyright: February 20, 2023
Journal of Basic and Clinical Physiology and Pharmacology
From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 34 Issue 2

Abstract

Objectives

Regular treadmill exercise may result in changes in pro-inflammatory cytokines and oxidative stress. However, the way acute treadmill exercise mechanisms affect the changes in pro-inflammatory cytokines and oxidative stress in obese has not been comprehensively exposed. This study aimed to analyze the pro-inflammatory cytokines and oxidative stress between 30 min before treadmill exercise and 24 h after treadmill exercise in obese adolescents.

Methods

A total of 20 obese females aged 19–24 years were recruited from female students and given one session of treadmill exercise with an intensity of 60–70% HRmax. Thiobarbituric acid reactive substance (TBARS) was used to analyze serum levels of MDA, while enzyme-linked immunosorbent assay (ELISA) was used to analyze serum levels of TNF-α and IL-6. Moreover, the independent samples t-test with a significance level of 5% was employed to have the statistical analysis.

Results

The results on 24 h after treadmill exercise and delta (Δ) between CTRL and TREG showed a significant difference (p<0.001).

Conclusions

This study found a decrease in pro-inflammatory cytokines and oxidative stress 24 h after treadmill exercise in obese adolescents. Therefore, treadmill exercise can be a promising strategy for preventing adolescents from obesity as well as preventing disease risks associated with oxidative stress and chronic inflammation.

Keywords: IL-6; MDA; obesity; TNF-α; treadmill exercise
Corresponding author: Purwo Sri Rejeki, Physiology Division, Department of Medical Physiology and Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia, Phone: +62 8214 1559 388, E-mail:

Funding source: Direktorat Riset Dan Pengabdian Kepada Masyarakat

Award Identifier / Grant number: 4/E1/KP.PTNBH/2021 and 292/UN3.15/PT/2021

Funding source: Universitas Airlangga

Award Identifier / Grant number: Unassigned

Award Identifier / Grant number: 4/E1/KP.PTNBH/2021 and 292/UN3.15/PT/2021

Acknowledgments

We would like to express our gratitude to the Management of Atlas Sports Club Malang for providing good facilities for making the process of screening prospective subjects and conducting research a success. We also thank Mrs. Eli Ning Khabidah, Amd. Kep, a medical analyst from the Patimura Clinical Laboratory Malang, for her kind help in the process of taking blood samples and blood centrifuge as well as Mrs. Umi Salamah, Amd as staff from the Laboratory of Physiology, Faculty of Medicine, Universitas Brawijaya who has helped us complete the process of analyzing the MDA, IL-6, TNF-α serum the levels. Last but not least is all subjects who have participated in this study.

  1. Research funding: This study is supported by the Directorate of Research and Community Services, Deputy for Strengthening Research and Development of the Ministry of Research and Technology/National Research and Innovation Agency, Indonesia, under Grand Number: 4/E1/KP.PTNBH/2021 and 292/UN3.15/PT/2021.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Written informed consent was obtained before the students were enrolled as the subjects.

  5. Ethical approval: This study has been approved by the Health Research Ethics Committee of the Faculty of Medicine, Universitas Airlangga, Surabaya, under registered number 192/KEPK/FKUA/2021.

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Received: 2022-09-04
Accepted: 2023-01-24
Published Online: 2023-02-20

© 2023 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jbcpp-2022-0196
Keywords for this article
IL-6; MDA; obesity; TNF-α; treadmill exercise

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. The clinical potential of flavonoids in Peyronie’s disease
  4. Reviews
  5. Emphasizing roles of BDNF promoters and inducers in Alzheimer's disease for improving impaired cognition and memory
  6. Diabetic wound healing approaches: an update
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  13. Implication of nitrergic system in the anticonvulsant effects of ferulic acid in pentylenetetrazole-induced seizures in male mice
  14. The effects of G protein-coupled receptor 30 (GPR30) on cardiac glucose metabolism in diabetic ovariectomized female rats
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  18. Letter to the Editor
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