Hypoglycemic and antioxidant effects of oral administration of garlic extract in the livers of type 1 diabetic rats
-
Hamid Behrouj
,
Roghayeh Abbasalipourkabir
Abstract
Background
Liver dysfunction is a predominant complication of diabetes. Herbal remedies such as garlic are commonly used for reducing diabetic complications. In this study the effect of garlic extract on glucose level, liver enzymes activities in the serum and nitric oxide (NO) level, oxidative stress status, and histology in the liver tissues of streptozotocin-induced diabetes (type 1) was investigated.
Methods
Twenty-four adult male Wistar rats were randomized and divided into four groups: control rats, diabetic rats, diabetic rats treated with garlic, and garlic-treated normal rats. Glucose level and liver enzymes activities were determined by colorimetric assay in the serum. NO levels by Griess method, oxidative stress parameters including malondialdehyde (MDA), total oxidative status (TOS), and total antioxidant capacity (TAC) by spectrophotometric method, and histopathological examination by hematoxylin and eosin staining method were evaluated in the liver tissues.
Results
Glucose level, liver enzymes activities, MDA, TOS, and NO levels were increased and TAC level decreased significantly in diabetic rats in comparison with control rats (p<0.01); whereas, after oral administration of garlic, glucose level, liver enzymes activities, MDA, TOS, and NO levels were decreased and TAC level increased significantly near to the normal levels (p<0.05).
Conclusion
The results showed the hypoglycemic and antioxidant effects of garlic in the livers of type 1 diabetic rats.
Acknowledgments
The authors would like to thank the Hamadan University of Medical Sciences (Hamadan, Iran) for financial support.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: The present study was funded by Vice-chancellor for Research and Technology, Hamadan University of Medical Sciences (No. 9311286063).
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2019 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Oxidative Stress
- Primary concept of nickel toxicity – an overview
- Behavior and Neuroprotection
- Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis
- Infection
- Opportunistic infection at the start of antiretroviral therapy and baseline CD4+ count less than 50 cells/mm3 are associated with poor immunological recovery
- Inflammation
- Antinociceptive and anti-inflammatory properties of Tetracera alnifolia Willd. (Dilleniaceae) hydroethanolic leaf extract
- Oxidative Stress
- Influence of eugenol on oxidative stress biomarkers in the liver of carrageenan-induced arthritis rats
- Selective serotonin reuptake inhibitor fluvoxamine ameliorates stress- and NSAID-induced peptic ulcer possibly by involving Hsp70
- The ethanol leaf extract of Andrographis paniculata blunts acute renal failure in cisplatin-induced injury in rats through inhibition of Kim-1 and upregulation of Nrf2 pathway
- Effect of l-carnitine on aspartame-induced oxidative stress, histopathological changes, and genotoxicity in liver of male rats
- Reproduction
- Sympathovagal imbalance and neurophysiologic cognitive assessment using evoked potentials in polycystic ovary syndrome in young adolescents – a cross-sectional study
- Phytotherapy
- Antidiabetic and antihyperlipidemic potential of ethanol extract of Salacia lehmbachii stem bark in alloxan-induced diabetic rats
- Hypoglycemic and antioxidant effects of oral administration of garlic extract in the livers of type 1 diabetic rats
- Anabasis aretioides Coss. & Moq. phenolic compounds exhibit in vitro hypoglycemic, antioxidant and antipathogenic properties
- Cardiovascular Function
- Cardioautonomic responses to acute ingestion of ice water and its correlation to body mass index
- Metabolism
- Repeated restraint stress upregulates rat sulfotransferase 1A1
- Case Report
- Tramadol-induced parkinsonism: a case report of a 75-year-old woman
Artikel in diesem Heft
- Frontmatter
- Oxidative Stress
- Primary concept of nickel toxicity – an overview
- Behavior and Neuroprotection
- Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis
- Infection
- Opportunistic infection at the start of antiretroviral therapy and baseline CD4+ count less than 50 cells/mm3 are associated with poor immunological recovery
- Inflammation
- Antinociceptive and anti-inflammatory properties of Tetracera alnifolia Willd. (Dilleniaceae) hydroethanolic leaf extract
- Oxidative Stress
- Influence of eugenol on oxidative stress biomarkers in the liver of carrageenan-induced arthritis rats
- Selective serotonin reuptake inhibitor fluvoxamine ameliorates stress- and NSAID-induced peptic ulcer possibly by involving Hsp70
- The ethanol leaf extract of Andrographis paniculata blunts acute renal failure in cisplatin-induced injury in rats through inhibition of Kim-1 and upregulation of Nrf2 pathway
- Effect of l-carnitine on aspartame-induced oxidative stress, histopathological changes, and genotoxicity in liver of male rats
- Reproduction
- Sympathovagal imbalance and neurophysiologic cognitive assessment using evoked potentials in polycystic ovary syndrome in young adolescents – a cross-sectional study
- Phytotherapy
- Antidiabetic and antihyperlipidemic potential of ethanol extract of Salacia lehmbachii stem bark in alloxan-induced diabetic rats
- Hypoglycemic and antioxidant effects of oral administration of garlic extract in the livers of type 1 diabetic rats
- Anabasis aretioides Coss. & Moq. phenolic compounds exhibit in vitro hypoglycemic, antioxidant and antipathogenic properties
- Cardiovascular Function
- Cardioautonomic responses to acute ingestion of ice water and its correlation to body mass index
- Metabolism
- Repeated restraint stress upregulates rat sulfotransferase 1A1
- Case Report
- Tramadol-induced parkinsonism: a case report of a 75-year-old woman
