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Tramadol-induced parkinsonism: a case report of a 75-year-old woman

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Published/Copyright: November 17, 2018
Journal of Basic and Clinical Physiology and Pharmacology
From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 30 Issue 2

Abstract

Adverse drug reaction (ADR) is a form of unwanted reaction and is the crucial reason for illness and death. Tramadol-induced parkinsonism is a kind of ADR that occurs after the repeated intake of tramadol. Long-term exposure to tramadol has been known to induce tremor and alter the functioning of dopamine. This case report introduces a 75-year-old woman diagnosed with tramadol-induced parkinsonism due to the administration of tramadol for the treatment of post-operated (breast cancer) acute onset of severe pain on the left side of the chest. The assessment of the offending drug was carried out via Naranjo probability scale. A score of 6 was reported for this patient, defining tramadol as a probable cause of this reaction. For the management of the drug-induced parkinsonism, levodopa/carbidopa was prescribed and the symptoms related to parkinsonism resolved within a week. The age of the patient and the female gender is considered to be the main risk factor for the occurrence of such reaction. This case report is an attempt to spread awareness about the negative consequences of long-term use of tramadol in old patients. Thus, the medical practitioners must be very careful while administering tramadol to the old aged population.

Keywords: adverse drug reaction; drug-induced parkinsonism; tramadol-induced parkinsonism

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2018-06-26
Accepted: 2018-10-19
Published Online: 2018-11-17

©2019 Walter de Gruyter GmbH, Berlin/Boston

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  10. Oxidative Stress
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  12. Selective serotonin reuptake inhibitor fluvoxamine ameliorates stress- and NSAID-induced peptic ulcer possibly by involving Hsp70
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  21. Cardiovascular Function
  22. Cardioautonomic responses to acute ingestion of ice water and its correlation to body mass index
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  24. Repeated restraint stress upregulates rat sulfotransferase 1A1
  25. Case Report
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https://doi.org/10.1515/jbcpp-2018-0113
Keywords for this article
adverse drug reaction; drug-induced parkinsonism; tramadol-induced parkinsonism

Articles in the same Issue

  1. Frontmatter
  2. Oxidative Stress
  3. Primary concept of nickel toxicity – an overview
  4. Behavior and Neuroprotection
  5. Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis
  6. Infection
  7. Opportunistic infection at the start of antiretroviral therapy and baseline CD4+ count less than 50 cells/mm3 are associated with poor immunological recovery
  8. Inflammation
  9. Antinociceptive and anti-inflammatory properties of Tetracera alnifolia Willd. (Dilleniaceae) hydroethanolic leaf extract
  10. Oxidative Stress
  11. Influence of eugenol on oxidative stress biomarkers in the liver of carrageenan-induced arthritis rats
  12. Selective serotonin reuptake inhibitor fluvoxamine ameliorates stress- and NSAID-induced peptic ulcer possibly by involving Hsp70
  13. The ethanol leaf extract of Andrographis paniculata blunts acute renal failure in cisplatin-induced injury in rats through inhibition of Kim-1 and upregulation of Nrf2 pathway
  14. Effect of l-carnitine on aspartame-induced oxidative stress, histopathological changes, and genotoxicity in liver of male rats
  15. Reproduction
  16. Sympathovagal imbalance and neurophysiologic cognitive assessment using evoked potentials in polycystic ovary syndrome in young adolescents – a cross-sectional study
  17. Phytotherapy
  18. Antidiabetic and antihyperlipidemic potential of ethanol extract of Salacia lehmbachii stem bark in alloxan-induced diabetic rats
  19. Hypoglycemic and antioxidant effects of oral administration of garlic extract in the livers of type 1 diabetic rats
  20. Anabasis aretioides Coss. & Moq. phenolic compounds exhibit in vitro hypoglycemic, antioxidant and antipathogenic properties
  21. Cardiovascular Function
  22. Cardioautonomic responses to acute ingestion of ice water and its correlation to body mass index
  23. Metabolism
  24. Repeated restraint stress upregulates rat sulfotransferase 1A1
  25. Case Report
  26. Tramadol-induced parkinsonism: a case report of a 75-year-old woman
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