Sympathovagal imbalance and neurophysiologic cognitive assessment using evoked potentials in polycystic ovary syndrome in young adolescents – a cross-sectional study
-
Deepika Velusami
and
Sivaranjini Sivasubramanian
Abstract
Background
Altered lifestyle and urbanization have potentially increased the prevalence of polycystic ovary syndrome (PCOS) among the women in India. The aim of the present study was to evaluate the autonomic function and subclinical cognition impairment using evoked potentials in PCOS-affected young adolescents.
Methods
This was a cross-sectional study, approved by Indian Medical of Council Research as a short-term student project. The study was performed with adolescent girls (age group, 10–18 years) diagnosed as having PCOS, attending the Department of Obstetrics and Gynecology at Sri Manakula Vinayagar Medical College and Hospital, Puducherry. Autonomic function was evaluated using heart rate variability and cognition employing auditory evoked potentials (P300 latency and amplitude) among the control group (n=30) and the PCOS group (n=30).
Results
Our study reports indicated that autonomic functions were significantly affected among the PCOS group compared to the control group (p=0.03), with sympathetic dominance and decreased vagal tone. P300 latency was prolonged and amplitude was decreased among the PCOS group, but the results were not statistically significant when compared to the control group. Body mass index showed significant correlation with sympathovagal imbalance.
Conclusion
The study indicates that autonomic functions are significantly altered in the PCOS group. Subclinical cognition impairment is seen among the PCOS group but is not pronounced enough to be proven statistically. This study informs adolescent girls to make early lifestyle changes as soon as possible before any significant clinical impairment occurs.
Acknowledgements
We acknowledge the Epidemiology Unit of the Department of Community Medicine for their technical support. Also, we acknowledge the Department of Obstetrics & Gynecology for their support.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: Indian Council of Medical Research.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2019 Walter de Gruyter GmbH, Berlin/Boston
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Articles in the same Issue
- Frontmatter
- Oxidative Stress
- Primary concept of nickel toxicity – an overview
- Behavior and Neuroprotection
- Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis
- Infection
- Opportunistic infection at the start of antiretroviral therapy and baseline CD4+ count less than 50 cells/mm3 are associated with poor immunological recovery
- Inflammation
- Antinociceptive and anti-inflammatory properties of Tetracera alnifolia Willd. (Dilleniaceae) hydroethanolic leaf extract
- Oxidative Stress
- Influence of eugenol on oxidative stress biomarkers in the liver of carrageenan-induced arthritis rats
- Selective serotonin reuptake inhibitor fluvoxamine ameliorates stress- and NSAID-induced peptic ulcer possibly by involving Hsp70
- The ethanol leaf extract of Andrographis paniculata blunts acute renal failure in cisplatin-induced injury in rats through inhibition of Kim-1 and upregulation of Nrf2 pathway
- Effect of l-carnitine on aspartame-induced oxidative stress, histopathological changes, and genotoxicity in liver of male rats
- Reproduction
- Sympathovagal imbalance and neurophysiologic cognitive assessment using evoked potentials in polycystic ovary syndrome in young adolescents – a cross-sectional study
- Phytotherapy
- Antidiabetic and antihyperlipidemic potential of ethanol extract of Salacia lehmbachii stem bark in alloxan-induced diabetic rats
- Hypoglycemic and antioxidant effects of oral administration of garlic extract in the livers of type 1 diabetic rats
- Anabasis aretioides Coss. & Moq. phenolic compounds exhibit in vitro hypoglycemic, antioxidant and antipathogenic properties
- Cardiovascular Function
- Cardioautonomic responses to acute ingestion of ice water and its correlation to body mass index
- Metabolism
- Repeated restraint stress upregulates rat sulfotransferase 1A1
- Case Report
- Tramadol-induced parkinsonism: a case report of a 75-year-old woman
