Startseite SIRT2 suppresses non-small cell lung cancer growth by targeting JMJD2A
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SIRT2 suppresses non-small cell lung cancer growth by targeting JMJD2A

  • Weihua Xu , Kanqiu Jiang , Mingjing Shen , Yongyue Qian und Yong Peng EMAIL logo
Veröffentlicht/Copyright: 14. März 2015
Biological Chemistry
Aus der Zeitschrift Biological Chemistry Band 396 Heft 8

Abstract

Lung cancer has been the most prolific cancer in China – as in the rest of the world – with a high death rate and low 5-year survival rate. Previous evidence showed that JMJD2A is over-expressed in human non-small cell lung cancer (NSCLC) tissues compared to adjacent normal tissues, and that high level of JMJD2A predicts poor overall and disease-free survival. However, the mechanism by which JMJD2A is regulated in human NSCLC is not fully understood. In the present study, we identified that the SIRT2 as an anti-oncogenic protein in NSCLC was down-regulated. JMJD2A as a target of SIRT2 was negatively correlated with SIRT2 level in NSCLC. SIRT2 bound to the promoter region of JMJD2A and negatively regulated JMJD2A expression. In addition, we found that SIRT2 inhibited NSCLC cells proliferation, colony formation and tumor growth in vitro and in vivo in a JMJD2A-dependent manner. In summary, our findings implicate that SIRT2 suppresses non-small cell lung cancer growth through targeting JMJD2A and SIRT2 activator may serve as candidate drug for NSCLC therapy.

Keywords: human non-small cell lung cancer; JMJD2A; SIRT2
Corresponding author: Yong Peng, Department of Cardiothoracic Surgery, Suzhou Municipal Hospital, 26 Daoqian Street, Suzhou 215002, Jiangsu, China, e-mail:
aThese authors contributed equally to this work.

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Supplemental Material

The online version of this article (DOI: 10.1515/hsz-2014-0284) offers supplementary material, available to authorized users.

Received: 2014-12-1
Accepted: 2015-2-12
Published Online: 2015-3-14
Published in Print: 2015-8-1

©2015 by De Gruyter

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https://doi.org/10.1515/hsz-2014-0284
Schlagwörter für diesen Artikel
human non-small cell lung cancer; JMJD2A; SIRT2

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
  3. Ras activation revisited: role of GEF and GAP systems
  4. When core competence is not enough: functional interplay of the DEAD-box helicase core with ancillary domains and auxiliary factors in RNA binding and unwinding
  5. Cathepsin S: therapeutic, diagnostic, and prognostic potential
  6. Minireview
  7. Overview of the roles of Sox2 in stem cell and development
  8. Research Articles/Short Communications
  9. Genes and Nucleic Acids
  10. Transcriptional and translational mechanisms contribute to regulate the expression of Discs Large 1 protein during different biological processes
  11. Membranes, Lipids, Glycobiology
  12. Rapid transfer of overexpressed integral membrane protein from the host membrane into soluble lipid nanodiscs without previous purification
  13. Molecular Medicine
  14. Characterization of a new dual-targeting fully human antibody with potent antitumor activity against nasopharyngeal carcinoma
  15. Cell Biology and Signaling
  16. Lithium chloride improves the efficiency of induced pluripotent stem cell-derived neurospheres
  17. SIRT2 suppresses non-small cell lung cancer growth by targeting JMJD2A
  18. Troglitazone suppresses glutamine metabolism through a PPAR-independent mechanism
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