Characterization of a new dual-targeting fully human antibody with potent antitumor activity against nasopharyngeal carcinoma
Abstract
Despite the effectiveness of the anti-EGFR chimeric antibody (mAb), cetuximab, in treating nasopharyngeal carcinoma (NPC), its efficacy remains variable and often modest. In this study, a full human dual targeted anti-EGFR/HER3 antibody, CA1182, was generated from phage display library. CA1182 was as effective as cetuximab or trastuzumab in inhabiting phosphorylation of EGFR or HER2, but it exhibited as much more potent than cetuximab or trastuzumab. Moreover, our studies showed that CA1182 was significantly more effective than cetuximab in prolonging the survival of severe combined immune deficient mice bearing human NPC, suggesting that it might be a promising therapeutic agent for NPC.
References
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©2015 by De Gruyter
Artikel in diesem Heft
- Frontmatter
- Reviews
- Ras activation revisited: role of GEF and GAP systems
- When core competence is not enough: functional interplay of the DEAD-box helicase core with ancillary domains and auxiliary factors in RNA binding and unwinding
- Cathepsin S: therapeutic, diagnostic, and prognostic potential
- Minireview
- Overview of the roles of Sox2 in stem cell and development
- Research Articles/Short Communications
- Genes and Nucleic Acids
- Transcriptional and translational mechanisms contribute to regulate the expression of Discs Large 1 protein during different biological processes
- Membranes, Lipids, Glycobiology
- Rapid transfer of overexpressed integral membrane protein from the host membrane into soluble lipid nanodiscs without previous purification
- Molecular Medicine
- Characterization of a new dual-targeting fully human antibody with potent antitumor activity against nasopharyngeal carcinoma
- Cell Biology and Signaling
- Lithium chloride improves the efficiency of induced pluripotent stem cell-derived neurospheres
- SIRT2 suppresses non-small cell lung cancer growth by targeting JMJD2A
- Troglitazone suppresses glutamine metabolism through a PPAR-independent mechanism
Artikel in diesem Heft
- Frontmatter
- Reviews
- Ras activation revisited: role of GEF and GAP systems
- When core competence is not enough: functional interplay of the DEAD-box helicase core with ancillary domains and auxiliary factors in RNA binding and unwinding
- Cathepsin S: therapeutic, diagnostic, and prognostic potential
- Minireview
- Overview of the roles of Sox2 in stem cell and development
- Research Articles/Short Communications
- Genes and Nucleic Acids
- Transcriptional and translational mechanisms contribute to regulate the expression of Discs Large 1 protein during different biological processes
- Membranes, Lipids, Glycobiology
- Rapid transfer of overexpressed integral membrane protein from the host membrane into soluble lipid nanodiscs without previous purification
- Molecular Medicine
- Characterization of a new dual-targeting fully human antibody with potent antitumor activity against nasopharyngeal carcinoma
- Cell Biology and Signaling
- Lithium chloride improves the efficiency of induced pluripotent stem cell-derived neurospheres
- SIRT2 suppresses non-small cell lung cancer growth by targeting JMJD2A
- Troglitazone suppresses glutamine metabolism through a PPAR-independent mechanism