MGL induces nuclear translocation of EndoG and AIF in caspase-independent T cell death
-
Qingpan Bu
Abstract
Macrophage galactose-type lectin (MGL) participates in the regulation of T cell apoptosis, but the exact death pathway remains unclear. Here, we demonstrated that MGL-induced T cell death occurs in a caspaseindependent manner. Furthermore, MGL treatment triggers the translocation of endonuclease G (EndoG) and apoptosis-inducing factor (AIF) from the mitochondria to the nucleus. Because galectin-1 (Gal-1) can also initiate similar mitochondrial events, we speculate that this death pathway may be widely used by the lectin family.
References
1. Dworacki, G., Meidenbauer, N., Kuss, I., Hoffmann, T.K., Gooding, W., Lotze, M. and Whiteside, T.L. Decreased ζ chain expression and apoptosis in CD3+ peripheral blood T lymphocytes of patients with melanoma. Clin. Cancer Res. 7 (2001) 947-957.Suche in Google Scholar
2. Hoffmann, T.K., Dworacki, G., Tsukihiro, T., Meidenbauer, N., Gooding, W., Johnson, J.T. and Whiteside, T.L. Spontaneous apoptosis of circulating T lymphocytes in patients with head and neck cancer and its clinical importance. Clin. Cancer Res. 8 (2002) 2553-2562.Suche in Google Scholar
3. Kim, J.W., Wieckowski, E., Taylor, D.D., Reichert, T.E., Watkins, S. and Whiteside, T.L. Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes. Clin. Cancer Res. 11 (2005) 1010-1020.Suche in Google Scholar
4. Kim, R., Emi, M. and Tanabe, K. Cancer immunoediting from immune surveillance to immune escape. Immunology 121 (2007) 1-14.Suche in Google Scholar
5. Cedeno-Laurent, F. and Dimitroff. C.J. Galectin-1 research in T cell immunity: past, present and future. Clin. Immunol. 142 (2012) 107-116.Suche in Google Scholar
6. Ito, K., Stannard, K., Gabutero, E., Clark, A.M., Neo, S.Y., Onturk, S., Blanchard, H. and Ralph, S.J. Galectin-1 as a potent target for cancer therapy: role in the tumor microenvironment. Cancer Metastasis Rev. 31 (2012) 763-778.10.1007/s10555-012-9388-2Suche in Google Scholar PubMed
7. Endharti, A.T., Zhou, Y.W., Nakashima, I. and Suzuki, H. Galectin-1 supports survival of naive T cells without promoting cell proliferation. Eur. J. Immunol. 35 (2005) 86-97.Suche in Google Scholar
8. Matarrese, P., Tinari, A., Mormone, E., Bianco, G.A., Toscano, M.A., Ascione, B., Rabinovich, G.A. and Malorni, W. Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission. J. Biol. Chem. 280 (2005) 6969-6985.10.1074/jbc.M409752200Suche in Google Scholar PubMed
9. Toscano, M.A., Bianco, G.A., Ilarregui, J.M., Croci, D.O., Correale, J., Hernandez, J.D., Zwirner, N.W., Poirier, F., Riley, E.M., Baum, L.G. and Rabinovich, G.A. Differential glycosylation of TH1, TH2 and TH17 effector cells selectively regulates susceptibility to cell death. Nat. Immunol. 8 (2007) 825-834.Suche in Google Scholar
10. Hahn, H.P., Pang, M., He, J., Hernandez, J.D., Yang, R.Y., Li, L.Y., Wang, X., Liu, F.T. and Baum, L.G. Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death. Cell Death Differ. 11 (2004) 1277-1286.Suche in Google Scholar
11. van Vliet, S.J., van Liempt, E., Geijtenbeek, T.B.H. and van Kooyk, Y. Differential regulation of C-type lectin expression on tolerogenic dendritic cell subsets. Immunobiology 211 (2006) 577-585.Suche in Google Scholar
12. van Vliet, S.J., Gringhuis, S.I., Geijtenbeek, T.B.H. and van Kooyk, Y. Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45. Nat. Immunol. 7 (2006) 1200-1208.Suche in Google Scholar
13. Lorenzo, H.K. and Susin, S.A. Mitochondrial effectors in caspaseindependent cell death. FEBS Lett. 557 (2004) 14-20.Suche in Google Scholar
14. Xu, G. and Shi, Y. Apoptosis signaling pathways and lymphocyte homeostasis. Cell Res. 17 (2007) 759-771. Suche in Google Scholar
15. Zhang, X., Ge, Y.L., Zhang, S.P., Yan, P. and Tian, R.H. Downregulation of KDR expression induces apoptosis in breast cancer cells. Cell. Mol. Biol. Lett. 19 (2014) 527-541.Suche in Google Scholar
16. Cregan, S.P., Dawson, V.L. and Slack, R.S. Role of AIF in caspasedependent and caspase-independent cell death. Oncogene 23 (2004) 2785-2796.Suche in Google Scholar
17. Pace, K.E., Lee, C., Stewart, P.L. and Baum, L.G. Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1. J. Immunol. 163 (1999) 3801-3811.Suche in Google Scholar
18. Gottfried, E., Kreutz, M. and Mackensen, A. Tumor-induced modulation of dendritic cell function. Cytokine Growth Factor Rev. 19 (2008) 65-77.10.1016/j.cytogfr.2007.10.008Suche in Google Scholar PubMed
19. Higashi, N., Morikawa, A., Fujioka, K., Fujita, Y., Sano, Y., Miyata- Takeuchi, M., Suzuki, N. and Irimura, T. Human macrophage lectin specific for galactose/N-acetylgalactosamine is a marker for cells at an intermediate stage in their differentiation from monocytes into macrophages. Int. Immunol. 14 (2002) 545-554.Suche in Google Scholar
20. Raes, G., Brys, L., Dahal, B.K., Brandt, J., Grooten, J., Brombacher, F., Vanham, G., Noel, W., Bogaert, P., Boonefaes, T., Kindt, A., Van den Bergh, R., Leenen, P.J.M., De Baetselier, P. and Ghassabeh, G.H. Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation. J. Leukocyte Biol. 77 (2005) 321-327.Suche in Google Scholar
21. Rubinstein, N., Alvarez, M., Zwirner, N.W., Toscano, M.A., Ilarregui, J.M., Bravo, A., Mordoh, J., Fainboim, L., Podhajcer, O.L. and Rabinovich, G.A. Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection: A potential mechanism of tumorimmune privilege. Cancer Cell. 5 (2004) 241-251.Suche in Google Scholar
22. Camby, I., Belot, N., Rorive, S., Lefranc, F., Maurage, C.A., Lahm, H., Kaltner, H., Hadari, Y., Ruchoux, M.M., Brotchi, J., Zick, E. and Salmon, I. Galectins are differentially expressed in supratentorial pilocytic astrocytomas, astrocytomas, anaplastic astrocytomas and glioblastomas, and significantly modulate tumor astrocyte migration. Brain Pathol. 11 (2006) 12-26.Suche in Google Scholar
23. He, J. and Baum, L.G. Endothelial cell expression of galectin-1 induced by prostate cancer cells inhibits T-cell transendothelial migration. Lab. Invest. 86 (2006) 578-590. Suche in Google Scholar
© University of Wroclaw, Poland
Artikel in diesem Heft
- How taste works: cells, receptors and gustatory perception
- Non-cooperative immobilization of residual water bound in lyophilized photosynthetic lamellae
- Coexistence of rare variant HbD Punjab [α2β2121(Glu→Gln)] and alpha 3.7 kb deletion in a young boy of Hindu family in West Bengal, India
- Somatic stem cell aging and malignant transformation – impact on therapeutic application
- 1H NMR-based metabolic profiling for evaluating poppy seed rancidity and brewing
- Homology arms of targeting vectors for gene insertions and CRISPR/Cas9 technology: size does not matter; quality control of targeted clones does
- Death domain associated protein (Daxx), a multi-functional protein
- In silico screening of alleged miRNAs associated with cell competition: an emerging cellular event in cancer
- MGL induces nuclear translocation of EndoG and AIF in caspase-independent T cell death
- Cerivastatin represses atherogenic gene expression through the induction of KLF2 via isoprenoid metabolic pathways
- Proteasomes raise the microtubule dynamics in influenza A (H1N1) virus-infected LLC-MK2 cells
- Purinergic signaling and the functioning of the nervous system cells
- The effect of cultureware surfaces on functional and structural components of differentiated 3T3-L1 preadipocytes
- Ramipril inhibits high glucose-stimulated up-regulation of adhesion molecules via the ERK1/2 MAPK signaling pathway in human umbilical vein endothelial cells
- The effect of nicotine on the expressions of the α7 nicotinic receptor gene and Bax and Bcl-2 proteins in the mammary gland epithelial-7 breast cancer cell line and its relationship to drug resistance
- The cloning, expression and purification of recombinant human neuritin from Escherichia coli and the partial analysis of its neurobiological activity
Artikel in diesem Heft
- How taste works: cells, receptors and gustatory perception
- Non-cooperative immobilization of residual water bound in lyophilized photosynthetic lamellae
- Coexistence of rare variant HbD Punjab [α2β2121(Glu→Gln)] and alpha 3.7 kb deletion in a young boy of Hindu family in West Bengal, India
- Somatic stem cell aging and malignant transformation – impact on therapeutic application
- 1H NMR-based metabolic profiling for evaluating poppy seed rancidity and brewing
- Homology arms of targeting vectors for gene insertions and CRISPR/Cas9 technology: size does not matter; quality control of targeted clones does
- Death domain associated protein (Daxx), a multi-functional protein
- In silico screening of alleged miRNAs associated with cell competition: an emerging cellular event in cancer
- MGL induces nuclear translocation of EndoG and AIF in caspase-independent T cell death
- Cerivastatin represses atherogenic gene expression through the induction of KLF2 via isoprenoid metabolic pathways
- Proteasomes raise the microtubule dynamics in influenza A (H1N1) virus-infected LLC-MK2 cells
- Purinergic signaling and the functioning of the nervous system cells
- The effect of cultureware surfaces on functional and structural components of differentiated 3T3-L1 preadipocytes
- Ramipril inhibits high glucose-stimulated up-regulation of adhesion molecules via the ERK1/2 MAPK signaling pathway in human umbilical vein endothelial cells
- The effect of nicotine on the expressions of the α7 nicotinic receptor gene and Bax and Bcl-2 proteins in the mammary gland epithelial-7 breast cancer cell line and its relationship to drug resistance
- The cloning, expression and purification of recombinant human neuritin from Escherichia coli and the partial analysis of its neurobiological activity
