Somatic stem cell aging and malignant transformation – impact on therapeutic application
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Marcela Kuniakova
Abstract
Somatic stem cells possess unique properties of self-renewal and plasticity which make them promising candidates for use in tissue engineering and regenerative medicine, in addition to serving as efficient delivery vehicles in site-specific therapy. In the case of therapeutic application, it is essential to isolate and culture stem cells in vitro, to obtain them in sufficient quantities. Although long-term cultivation provides an adequate number of cells, it has been shown that this approach is associated with increased risk of transformation of cultured cells, which presents a significant biological hazard. This article reviews information about biological features and cellular events which occur during long-term cultivation of somatic stem cells, with respect to their safe utilization in potential clinical practice.
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Articles in the same Issue
- How taste works: cells, receptors and gustatory perception
- Non-cooperative immobilization of residual water bound in lyophilized photosynthetic lamellae
- Coexistence of rare variant HbD Punjab [α2β2121(Glu→Gln)] and alpha 3.7 kb deletion in a young boy of Hindu family in West Bengal, India
- Somatic stem cell aging and malignant transformation – impact on therapeutic application
- 1H NMR-based metabolic profiling for evaluating poppy seed rancidity and brewing
- Homology arms of targeting vectors for gene insertions and CRISPR/Cas9 technology: size does not matter; quality control of targeted clones does
- Death domain associated protein (Daxx), a multi-functional protein
- In silico screening of alleged miRNAs associated with cell competition: an emerging cellular event in cancer
- MGL induces nuclear translocation of EndoG and AIF in caspase-independent T cell death
- Cerivastatin represses atherogenic gene expression through the induction of KLF2 via isoprenoid metabolic pathways
- Proteasomes raise the microtubule dynamics in influenza A (H1N1) virus-infected LLC-MK2 cells
- Purinergic signaling and the functioning of the nervous system cells
- The effect of cultureware surfaces on functional and structural components of differentiated 3T3-L1 preadipocytes
- Ramipril inhibits high glucose-stimulated up-regulation of adhesion molecules via the ERK1/2 MAPK signaling pathway in human umbilical vein endothelial cells
- The effect of nicotine on the expressions of the α7 nicotinic receptor gene and Bax and Bcl-2 proteins in the mammary gland epithelial-7 breast cancer cell line and its relationship to drug resistance
- The cloning, expression and purification of recombinant human neuritin from Escherichia coli and the partial analysis of its neurobiological activity
