Alkyl glycosides as potential anti-Candida albicans growth agents

Tomáš Klunda; Eva Machová; Alžbeta Čížová; Radim Horák; Monika Poláková; Slavomír Bystrický

doi:10.1515/chempap-2016-0051

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Alkyl glycosides as potential anti-Candida albicans growth agents

Tomáš Klunda , Eva Machová , Alžbeta Čížová , Radim Horák , Monika Poláková und Slavomír Bystrický

Veröffentlicht/Copyright: 22. April 2016

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Aus der Zeitschrift Chemical Papers Band 70 Heft 9

Abstract

Candida infections are becoming increasingly prevalent and many clinical isolates are resistant to common azole derivatives treatment. Accordingly, the capacity of a series of 19 alkyl glycosides, mainly mannosides and glucosides but also a cellobioside with aglycone chain-length from C-6 to C-20, to inhibit the growth of laboratory and clinically isolated strains of Candida albicans, was investigated. The study showed that only glycosides with the C-10 and C-12 aglycones were effective growth inhibitors of both types of Candida strains, whose metabolic activity was also significantly reduced as revealed by an XTT assay.

Keywords: susceptibility; synthetic glycosides; Candida albican

Acknowledgements

This work was supported by the Slovak Research and Development Agency (project no. APVV-0484-12), the Scientific Grant Agency of the Ministry of Education of the Slovak Republic and the Slovak Academy of Sciences (project nos. VEGA-2/0064/15 and 2/0026/13), and by the European Social Fund (project no. CZ. 1.07/2.4.00/31.0130) and IGA (IGAPrF2014026)

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Received: 2015-6-17

Revised: 2016-2-3

Accepted: 2016-2-7

Published Online: 2016-4-22

Published in Print: 2016-9-1

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https://doi.org/10.1515/chempap-2016-0051

Schlagwörter für diesen Artikel

susceptibility; synthetic glycosides; Candida albican