Chitosan sponge matrices with β-cyclodextrin for berberine loadinging

Mária Hnátová; Dušan Bakoš; L’udmila Černáková; Monika Michliková

doi:10.1515/chempap-2016-0015

Article

Chitosan sponge matrices with β-cyclodextrin for berberine loadinging

Mária Hnátová , Dušan Bakoš , L’udmila Černáková and Monika Michliková

Published/Copyright: February 11, 2016

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From the journal Chemical Papers Volume 70 Issue 9

Abstract

Biocompatible polymer sponge materials based on biodegradable natural polymer chitosan, which can be loaded with clinician-selected drugs are still in the centre of interest for their wide use in clinical practice. This study shows possibilities of the technology which combines simple addition of β-cyclodextrin (β-CD), with dialdehyde starch (DAS) as a cross-linking agent of chitosan, to chitosan solutions for subsequent formation of sponge matrix. The advantage of such system is in avoiding chemical modifications and working only with natural substances. It is shown that, in matrix formation during lyophilisation, β-CD molecules tend to accumulate on the surface of the porous matrix structure. This was confirmed by a study of the known inclusion complex of β-CD and salicylic acid (SA) in heptane. The same study was applied to berberine (BER) which can also form an inclusion complex with β-CD in a water solution. Moreover, adsorption of drugs on the surface of the porous structure has to be also taken into account. This enables the production of sponge topical medical preparations useful for sustained release of BER.

Keywords: chitosan sponge matrix; cyclodextrin; surface properties; berberine release; lyophilisation

^‡ Presented at the 6th International Conference on Polymeric Materials in Automotive & 22nd Slovak Rubber Conference (PMA2015 & SRC), Bratislava, Slovakia, 26–28 May, 201.5

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Received: 2015-9-30

Revised: 2015-11-20

Accepted: 2015-11-25

Published Online: 2016-2-11

Published in Print: 2016-9-1

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Articles in the same Issue

https://doi.org/10.1515/chempap-2016-0015

Keywords for this article

chitosan sponge matrix; cyclodextrin; surface properties; berberine release; lyophilisation