Startseite Heterocyclisation of substituted ylidenethiocarbonohydrazides using dimethyl acetylenedicarboxylate
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Heterocyclisation of substituted ylidenethiocarbonohydrazides using dimethyl acetylenedicarboxylate

  • Alaa A. Hassan EMAIL logo , Fathy F. Abdel-Latif , Mohamed Abdel Aziz , Sara M. Mostafa , Stefan Bräse und Martin Nieger
Veröffentlicht/Copyright: 27. März 2015
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Abstract

A facile and rapid procedure for the synthesis of dimethyl-2-[3-amino-5-(2-methoxy-2-oxoethylidene)- 4-oxothiazolidin-2-ylidenehydrazono]succinate, dimethyl {[2-alkylidenehydrazono)-5-(2-methoxy- 2-oxoethylidene)-4-oxothiazolidin-3-yl)amino]succinate and methyl (4-amino-5-oxo-3- thioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-yl)acetate affording yields of 61-54 %, 22-18 % and 14- 11 %, respectively, via a condensation reaction of dimethyl acetylenedicarboxylate (DMAD) with (substituted ylidene)thiocarbonohydrazides. One of the products was conclusively confirmed by single-crystal X-ray analysis. A mechanism for the formation of the products is presented.

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Received: 2014-8-12
Revised: 2014-12-5
Accepted: 2014-12-8
Published Online: 2015-3-27
Published in Print: 2015-7-1

© 2015 Institute of Chemistry, Slovak Academy of Sciences

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