Efficient method for the synthesis of polysubstituted 2,6-dicyanoanilines by one-pot three-component tandem reaction of malononitrile with α,β-unsaturated imines
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Wei Chen
Abstract
A facile and efficient one-pot synthesis of polysubstituted benzenes was achieved via the Michael addition of malononitrile with α,β-unsaturated imines and a sequential tandem reaction. This reaction generates polysubstituted 2,6-dicyanoanilines in high yields (15 examples, isolated yields of 57-91 %), and proceeds under mild reaction conditions (60°C, 10 min). In addition, a possible mechanism accounting for the reaction is proposed.
References
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Articles in the same Issue
- Voltammetric determination of B1 and B6 vitamins using a pencil graphite electrode
- An electrochemical sensor for sensitive determination of nitrites based on Ag–Fe3O4–graphene oxide magnetic nanocomposites
- Effect of influent nitrogen concentration on feasibility of short-cut nitrification during wastewater treatment in activated sludge systems
- Assessment of Urtica as a low-cost adsorbent for methylene blue removal: kinetic, equilibrium, and thermodynamic studies
- Electrode and electrodeless impedance measurement for determination of orange juices parameters
- Evaluation of oxidative stability of vegetable oils enriched with herb extracts by EPR spectroscopy
- Electrosynthesis of poly(p-phenylene) and poly(p-phenylene/pyrrole) films under controlled humidity
- Synthesis, characterisation, and electrical properties of novel nanostructured conducting poly(aniline-co-m-chloroaniline) with incorporated silver particles
- Heterocyclisation of substituted ylidenethiocarbonohydrazides using dimethyl acetylenedicarboxylate
- Newly synthesized indolizine derivatives – antimicrobial and antimutagenic properties
- Synthesis and insecticidal activity of anthranilic diamides with hydrazone substructure
- Effect of alkylated diphenylamine on thermal-oxidative degradation behavior of poly-α-olefin
- Novel pathways of interaction of maleic anhydride derivatives with phosphorus(III) compounds: synthesis and characterisation of N,N,N′,N′ -tetraethyl-2,3-diphenylbut-2-enediamide and 3-dihydrofuranylidene-4-phosphorylidene–oxolane-2,5,5′-trione
- Efficient method for the synthesis of polysubstituted 2,6-dicyanoanilines by one-pot three-component tandem reaction of malononitrile with α,β-unsaturated imines
