Fabrication of paper-based analytical device by silanisation of filter cellulose using alkyltrimethoxysilane coupled with UV radiation
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Long-Fei Cai
,
Ming-Hua Zhong
Abstract
A method was developed for the fabrication of microfluidic paper-based analytical devices (μPAD). This method was based on the silanisation of cellulose in filter paper using alkyltrimethoxysilane coupled with UV radiation. The filter paper sheet was hydrophobised by immersion in an octadecyltrimethoxysilane/heptane (OTMS/heptane) solution (0.25 vol. %) containing 5 vol. % of ethyl acetate (EtOAc). The hydrophobic-hydrophilic contrast was generated on the filter paper after the hydrophobised paper sheet was exposed to UV light with a metal mask creating the desired pattern on the sheet. The exposed area was oxidised to create a hydrophilic area, while the hydrophobic area was protected by the metal mask. The optimal conditions for the fabrication of μPAD were studied; these included ethyl acetate concentration (CEtOAc), immersion time, octadecyltrimethoxysilane concentration (COTMS) and exposure time. This method is costeffective and simple. In addition, different functional groups could be further grafted for various assay purposes. To demonstrate the feasibility of the μPAD in analytical applications, a flowershaped μPAD with eight channels and eight detection units was fabricated and used to determine the nitrite content in pickled vegetables. The nitrite content (124 μg g−1) in the sample determined by this method compared favourably with that measured using a standard method (137 μg g−1).
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© 2015 Institute of Chemistry, Slovak Academy of Sciences
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Artikel in diesem Heft
- Selection and design of ionic liquids as solvents in extractive distillation and extraction processes
- Analytical procedure for steroid profiling valid for Athlete Biological Passport
- Fabrication of paper-based analytical device by silanisation of filter cellulose using alkyltrimethoxysilane coupled with UV radiation
- Synthesis, characterisation and photocatalytic activity of Ag+- and Sn2+-substituted KSbTeO6
- Dysprosium pertraction through facilitated supported liquid membrane using D2EHPA as carrier
- Volatile compounds composition and antioxidant activity of bee pollen collected in Lithuania
- Self-penetrating and interpenetrating 3D metal–organic frameworks constructed from 4-(4-carboxyphenoxy)-phthalic acid and N-donor auxiliary ligands
- Preparation of ceramic γ-Al2O3–TiO2 nanofiltration membranes for desalination
- Promoting effect of group VI metals on Ni/MgO for catalytic growth of carbon nanotubes by ethylene chemical vapour deposition
- Microwave-assisted solvent-free synthesis and luminescence properties of 2-substituted-4,5-di(2-furyl)-1H-imidazoles
- Synthesis of potential inhibitors of glycosyltransferases representing UDP-GlcNAc
- Development of transition state analogue inhibitors for N-acetylglycosyltransferases bearing D-psicoor D-tagatofuranose scaffolds
- Efavirenz–eudragit E-100 nanoparticle-loaded aerosol foam for sustained release: in-vitro and ex-vivo evaluation
- Photochromic and molecular switching behaviour of Schiff base-containing pyrazolone ring
- Improvements to CO2 headspace biodegradability test
- Synthesis of corn rootworm pheromones from commercial diols
