Synthesis of potential inhibitors of glycosyltransferases representing UDP-GlcNAc
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Marek Baráth
,
Miroslav Koóš
Abstract
Based on rational design of the transition state analog inhibitors of glycosyltransferases, four model glycomimetics of this type, viz. benzyl 2-thio-α-D-fructofuranoside 1-diethylphosphate (XIa), its β-anomer (XIb), and their ethyl 2-thio analogs - α-anomer (XIIa) and β-anomer (XIIb), were synthesized. In addition, fourteen precursors arising during the synthesis of the desired final model compounds (XI and XII), partially or fully acetylated benzyl and/or ethyl 2-thiofructofuranoside 1-diethyl phosphates, were isolated and characterized with the aim to prepare complete series of glycomimetics, representing donor UDP-GlcNAc designated for biological assays on human GnT’s, viz. GnT-I, Core2GnT, and GnT-V.
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© 2015 Institute of Chemistry, Slovak Academy of Sciences
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- Selection and design of ionic liquids as solvents in extractive distillation and extraction processes
- Analytical procedure for steroid profiling valid for Athlete Biological Passport
- Fabrication of paper-based analytical device by silanisation of filter cellulose using alkyltrimethoxysilane coupled with UV radiation
- Synthesis, characterisation and photocatalytic activity of Ag+- and Sn2+-substituted KSbTeO6
- Dysprosium pertraction through facilitated supported liquid membrane using D2EHPA as carrier
- Volatile compounds composition and antioxidant activity of bee pollen collected in Lithuania
- Self-penetrating and interpenetrating 3D metal–organic frameworks constructed from 4-(4-carboxyphenoxy)-phthalic acid and N-donor auxiliary ligands
- Preparation of ceramic γ-Al2O3–TiO2 nanofiltration membranes for desalination
- Promoting effect of group VI metals on Ni/MgO for catalytic growth of carbon nanotubes by ethylene chemical vapour deposition
- Microwave-assisted solvent-free synthesis and luminescence properties of 2-substituted-4,5-di(2-furyl)-1H-imidazoles
- Synthesis of potential inhibitors of glycosyltransferases representing UDP-GlcNAc
- Development of transition state analogue inhibitors for N-acetylglycosyltransferases bearing D-psicoor D-tagatofuranose scaffolds
- Efavirenz–eudragit E-100 nanoparticle-loaded aerosol foam for sustained release: in-vitro and ex-vivo evaluation
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