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Clinical and pathological features of B-cell non-Hodgkin lymphomas lacking the surface expression of immunoglobulin light chains
-
Hiromichi Matsushita
,
Naoya Nakamura
Veröffentlicht/Copyright:
16. März 2012
Abstract
Background: The flow cytometric analysis of surface immunoglobulin light chains (sIgL) is used as a simple method for evaluating monoclonal B-cell proliferation. However, the sIgL expression, κ or λ, is occasionally undetectable in cases with B-cell non-Hodgkin lymphomas (B-NHL). The purpose of this study was to investigate the clinical and pathological characteristics of these B-NHL cases.
Methods: We retrospectively analyzed 50 cases with previously untreated sIgL-negative B-NHL. All of these cases had been diagnosed at Tokai University Hospital between January 2001 and February 2011. Their medical charts were reviewed.
Results: These cases had several clinical features: diffuse large B-cell lymphoma (DLBCL) (72%), a high serum lactate dehydrogenase level (66%), clinical stage III and IV (68%), and complex karyotypes (58%). Seven out of eight evaluated patients (87%) did not express cytoplasmic IgL, and the DNA rearrangement pattern of IgL showed diversity in 10 analyzed patients. The 5-year event-free survival of all the sIgL-negative B-NHL cases was significantly better with rituximab-containing chemotherapies in comparison to the regimens without it (57.9% vs. 17.9%, p=0.0207), although there was no statistical significance when the DLBCL cases were analyzed (56.6% vs. 22.2%, p=0.1530).
Conclusions: These findings suggest that sIgL-negative B-NHL cases predominantly developed DLBCL in advanced disease, but were heterogeneous at the molecular level.
Keywords: diffuse large B-cell lymphoma; non-Hodgkin lymphoma; rituximab; southern blotting analysis; surface immunoglobulin light chains
Received: 2011-11-17
Accepted: 2012-2-21
Published Online: 2012-3-16
Published in Print: 2012-9-1
©2012 by Walter de Gruyter Berlin Boston
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Schlagwörter für diesen Artikel
diffuse large B-cell lymphoma;
non-Hodgkin lymphoma;
rituximab;
southern blotting analysis;
surface immunoglobulin light chains
Artikel in diesem Heft
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- Editorials
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