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Validation of a new generation POCT glucose device with emphasis on aspects important for glycemic control in the hospital care
-
Snježana Kos
,
Arie van Meerkerk
Veröffentlicht/Copyright:
16. März 2012
Abstract
Background: Point-of-care (POC) glucose devices are widely used for insulin-dosage decision-making although such an application is not always permitted. In this study, we have evaluated a new generation of POC glucose device, the HemoCue® Glucose 201DMRT (201DMRT), for its suitability for (tight) glycemic control.
Materials and methods: This study was performed according to the CLSI/STARD criteria. The 201DMRT was compared to the laboratory hexokinase glucose method (Siemens Dimension Vista®). The variation among different POC devices and cuvette lot numbers was examined. Additionally, the influence of the partial pressure of oxygen and hematocrit on glucose measurement was investigated.
Results: The 201DMRT showed a good agreement with the laboratory reference method. This was examined using Deming regression analysis, percentage Bland-Altman plot and a modified Clarke-error grid. The total analytical error at the clinically critical glucose concentrations of 5.6, 7.0 and 11.1 mmol/L (101, 126 and 200 mg/dL) was 6.4%, 4.3% and 3.0%, respectively. The total error among the different POC devices and among different cuvette lot numbers was <6.5%. Glucose measurements on the 201DMRT were not affected by changes in partial pressure of oxygen, whereas changes in hematocrit had influence on the results (3.4% for every 0.10 L/L change in hematocrit).
Conclusions: The 201DMRT device can be used for glycemic control based on analytical results presented. However, the clinical applicability for tight glycemic control must be confirmed in a clinical study.
Received: 2011-12-4
Accepted: 2012-2-24
Published Online: 2012-3-16
Published in Print: 2012-9-1
©2012 by Walter de Gruyter Berlin Boston
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- Neutrophil gelatinase-associated lipocalin (NGAL): the laboratory perspective
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- Serum creatinine and the search for new biomarkers of acute kidney injury (AKI): the story continues
- Interference of new oral anticoagulants with frequently used coagulation tests
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