Global DNA hypomethylation in cancer: review of validated methods and clinical significance
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Estela G. Toraño
Estela G. Toraño is a first year PhD student in Cancer Epigenetics under the supervision of Dr. Mario F. Fraga. She has a fellowship from FICYT (Fundación para el fomento en Asturias de la investigación científica aplicada y la tecnología). Before she began her phD, she graduated in Biology and enrolled a master in cancer research at the University of Oviedo. Her work is focused on changes in post-translational modifications of histones during cellular differentiation and tumorigenesis. Also, she works in the study of methylomes of cancer and is familiar with the methods to analyze DNA methylation.
Originally from Menorca (Spain), graduated in Biotechnology and currently Biomedical Sciences master student (Cancer Genomics and Developmental Biology Programme) at the University of Utrecht (The Netherlands). Relevant research experience in genetic epidemiology of bladder cancer, epigenetics in monozygotic twins and developmental biology of blood endothelial cells in zebrafish. Awarded with a Summer-Training fellowship by the
Spanish National Cancer Research Centre (CNIO) in 2010 and with a Collaboration grant from theSpanish Ministry of Education and Science (MEC) in 2010–2011.Agustin F. Fernandez is, at present, a Miguel Servet researcher at the University Institute of Oncology of Asturias (IUOPA) where he works in the Cancer Epigenetics laboratory located at the Asturias Central University Hospital (HUCA), Oviedo, Spain. He received his PhD in Genetics from the University of Oviedo, and worked as postdoctoral fellow in the Laboratory of Cancer Epigenetics at the Spanish National Cancer Research Centre (CNIO), Madrid, Spain, and, later, at the Bellvitge Institute for Biomedical Research (IDIBELL), Barcelona, Spain. His main research areas are in the field of epigenetics and comprise the epigenetic mechanisms involved in cell differentiation, and their alterations in aging and different pathologies including cancer.
Mario F. Fraga is a Tenured Scientist at the National Centre of Biotechnology (CNB-CSIC) and the Head of the Cancer Epigenetics Laboratory at the Institute of Oncology of Asturias (IUOPA), Spain. He received his PhD in plant epigenetics from the University of Oviedo, and was a “Ramon y Cajal” postdoctoral fellow at the Spanish National Cancer Research Centre (CNIO), where he focused his research on cancer epigenetics and the study of human interindividual epigenetic variation. The research interests of his team are epigenetic processes involved in cell differentiation and their alterations in cancer and aging.
©2012 by Walter de Gruyter Berlin Boston
Artikel in diesem Heft
- Masthead
- Masthead
- Editorials
- Cancer epigenomics: moving slowly, but at a steady pace from laboratory bench to clinical practice
- Laboratory networking and sample quality: a still relevant issue for patient safety
- Reviews
- DNA methylation biomarkers and their utility for solid cancer diagnostics
- DNA methylation biomarkers in biological fluids for early detection of respiratory tract cancer
- Global DNA hypomethylation in cancer: review of validated methods and clinical significance
- Genetics and Molecular Diagnostics
- δ0-Thalassemia in cis of βKnossos globin gene: first homozygous description in thalassemia intermedia Libyans and first combination with codon 39 (C→T) in thalassemia intermedia Tunisian patients
- Genetic-based reference values for angiotensin-converting enzyme (ACE) according to I/D polymorphism in a Spanish population sample
- General Clinical Chemistry and Laboratory Medicine
- Effects of sample transportation on commonly requested laboratory tests
- Long-term (in)stability of folate and vitamin B12 in human serum
- Information comparison of the effects of drugs on laboratory tests in drug labels and Young’s book
- First evaluation of Capillarys 2 Flex Piercing® (Sebia) as a new analyzer for HbA1c assay by capillary electrophoresis
- Antioxidant and oligonutrient status, distribution of amino acids, muscle damage, inflammation, and evaluation of renal function in elite rugby players
- Validation of the body fluid module on the new Sysmex XN-1000 for counting blood cells in cerebrospinal fluid and other body fluids
- Measuring Rivaroxaban in a clinical laboratory setting, using common coagulation assays, Xa inhibition and thrombin generation
- Cancer Diagnostics
- Increased concentrations of growth factors and activation of the EGFR system in breast cancer
- Infectious Diseases
- Incidence and significance of elevated lactate in the identification of critically ill patients
- Cardiovascular Diseases
- Lipoprotein-associated phospholipase A2 is elevated in patients with severe aortic valve stenosis without clinically overt atherosclerosis
- Diabetes
- Serum cystatin C as a marker for early detection of chronic kidney disease and grade 2 nephropathy in Japanese patients with type 2 diabetes
- Letters to the Editor
- Establishing professional phlebotomist group for quality control of the preanalytic variables of clinical laboratory
- Application of quality specification based on biological variation in planning quality control strategy
- Analytical and clinical evaluation of a new immunoassay for therapeutic drug monitoring of infliximab and adalimumab
- Comparison of relationships between FT4 and log TSH in Access DXI 800 Unicel, Modular E170 and ADVIA Centaur XP Analyzer
- Assay-specific pitfalls of catecholamine HPLC assays
- Evaluation of automated nucleated red blood cells counting on Sysmex XE5000 and Siemens ADVIA 2120
- Evaluation of the immature myeloid information (IMI) by Sysmex XE 2100® hematology analyzer in the identification of blasts of myeloid lineage
- Congress Abstracts
- Congress of Laboratory Medicine and Clinical Chemistry / 4th Annual Meeting of the Austrian Society for Laboratory Medicine and Clinical Chemistry (ÖGLMKC)
- Abstracts of the 2012 Convocation of Experts on Laboratory Quality / Embracing the Need of Continued Vigilance to Assure Quality Outcomes in the Modern Laboratory
Artikel in diesem Heft
- Masthead
- Masthead
- Editorials
- Cancer epigenomics: moving slowly, but at a steady pace from laboratory bench to clinical practice
- Laboratory networking and sample quality: a still relevant issue for patient safety
- Reviews
- DNA methylation biomarkers and their utility for solid cancer diagnostics
- DNA methylation biomarkers in biological fluids for early detection of respiratory tract cancer
- Global DNA hypomethylation in cancer: review of validated methods and clinical significance
- Genetics and Molecular Diagnostics
- δ0-Thalassemia in cis of βKnossos globin gene: first homozygous description in thalassemia intermedia Libyans and first combination with codon 39 (C→T) in thalassemia intermedia Tunisian patients
- Genetic-based reference values for angiotensin-converting enzyme (ACE) according to I/D polymorphism in a Spanish population sample
- General Clinical Chemistry and Laboratory Medicine
- Effects of sample transportation on commonly requested laboratory tests
- Long-term (in)stability of folate and vitamin B12 in human serum
- Information comparison of the effects of drugs on laboratory tests in drug labels and Young’s book
- First evaluation of Capillarys 2 Flex Piercing® (Sebia) as a new analyzer for HbA1c assay by capillary electrophoresis
- Antioxidant and oligonutrient status, distribution of amino acids, muscle damage, inflammation, and evaluation of renal function in elite rugby players
- Validation of the body fluid module on the new Sysmex XN-1000 for counting blood cells in cerebrospinal fluid and other body fluids
- Measuring Rivaroxaban in a clinical laboratory setting, using common coagulation assays, Xa inhibition and thrombin generation
- Cancer Diagnostics
- Increased concentrations of growth factors and activation of the EGFR system in breast cancer
- Infectious Diseases
- Incidence and significance of elevated lactate in the identification of critically ill patients
- Cardiovascular Diseases
- Lipoprotein-associated phospholipase A2 is elevated in patients with severe aortic valve stenosis without clinically overt atherosclerosis
- Diabetes
- Serum cystatin C as a marker for early detection of chronic kidney disease and grade 2 nephropathy in Japanese patients with type 2 diabetes
- Letters to the Editor
- Establishing professional phlebotomist group for quality control of the preanalytic variables of clinical laboratory
- Application of quality specification based on biological variation in planning quality control strategy
- Analytical and clinical evaluation of a new immunoassay for therapeutic drug monitoring of infliximab and adalimumab
- Comparison of relationships between FT4 and log TSH in Access DXI 800 Unicel, Modular E170 and ADVIA Centaur XP Analyzer
- Assay-specific pitfalls of catecholamine HPLC assays
- Evaluation of automated nucleated red blood cells counting on Sysmex XE5000 and Siemens ADVIA 2120
- Evaluation of the immature myeloid information (IMI) by Sysmex XE 2100® hematology analyzer in the identification of blasts of myeloid lineage
- Congress Abstracts
- Congress of Laboratory Medicine and Clinical Chemistry / 4th Annual Meeting of the Austrian Society for Laboratory Medicine and Clinical Chemistry (ÖGLMKC)
- Abstracts of the 2012 Convocation of Experts on Laboratory Quality / Embracing the Need of Continued Vigilance to Assure Quality Outcomes in the Modern Laboratory
