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Antioxidant and oligonutrient status, distribution of amino acids, muscle damage, inflammation, and evaluation of renal function in elite rugby players

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Published/Copyright: April 26, 2012
Clinical Chemistry and Laboratory Medicine
From the journal Clinical Chemistry and Laboratory Medicine Volume 50 Issue 10

Abstract

Background: Our study investigated the biochemical and anthropometric characteristics in elite athletes of rugby union based in the south of France during the different periods of the competition to identify metabolic and biochemical adaptations to particular lifestyle conditions.

Methods: Participants included 35 players in 2008 and 43 players in 2009. Biochemical variables [creatinine, uric acid, creatine kinase (CK), alanine aminotransferase, aspartate aminotransferase, C-reactive protein] were evaluated. Specific protein levels (albumin, acid α-glycoprotein, prealbumin), vitamins (A, E, C), antioxidant enzymes [glutathione peroxidase (GPx), superoxide dismutase (SOD)], oligoelements (Zn, Se, Cu, erythrocyte magnesium), homocysteine (Hcy), carnitine and the distribution of amino acids were specifically determined for our study during a pre-competition period (September 2008 and 2009).

Results: Globally, no deficit was observed for vitamins, oligonutrients and amino acids levels. The high SOD and GPx activities in rugby players suggest a presence of oxidative stress of exercise. The evaluation of renal function should be used with caution because of the interaction between creatinine and lean body mass. In addition, a profound effect of intense exercise on the CK values was reported to establish specific reference values for athletes. The analysis of the biological variation allows optimization of the interpretation of the changes from an increased or decreased baseline value from a season to the other one.

Conclusions: The conclusions of present study were: 1) the necessity of rugby-specific reference intervals for CK and creatinine parameters; 2) the use of enzymatic creatinine for Modification of Diet in Renal Disease (MDRD) and CKD-EPI, or cystatin C to improve glomerular filtration rate estimation; 3) to take into account the oxidative stress testifying of a bad recovery; and 4) better to take care the nutritional status of the players by adapting needs and amino acids supplementations but also to consider a follow-up of oxidative stress and antioxidants according our results.

Keywords: creatine kinase; creatinine; intensive exercise; oxidative stress; reference values; rugby
Corresponding author: Jean Paul Cristol, Department of Biochemistry, Lapeyronie Hospital, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier cédex 5, France Phone: +33 4 67338314, Fax: +33 4 67338393
Received: 2012-2-21
Accepted: 2012-3-27
Published Online: 2012-04-26
Published in Print: 2012-10-01

©2012 by Walter de Gruyter Berlin Boston

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https://doi.org/10.1515/cclm-2012-0109
Keywords for this article
creatine kinase; creatinine; intensive exercise; oxidative stress; reference values; rugby

Articles in the same Issue

  1. Masthead
  2. Masthead
  3. Editorials
  4. Cancer epigenomics: moving slowly, but at a steady pace from laboratory bench to clinical practice
  5. Laboratory networking and sample quality: a still relevant issue for patient safety
  6. Reviews
  7. DNA methylation biomarkers and their utility for solid cancer diagnostics
  8. DNA methylation biomarkers in biological fluids for early detection of respiratory tract cancer
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  10. Genetics and Molecular Diagnostics
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  16. Information comparison of the effects of drugs on laboratory tests in drug labels and Young’s book
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  33. Comparison of relationships between FT4 and log TSH in Access DXI 800 Unicel, Modular E170 and ADVIA Centaur XP Analyzer
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