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Serum β2-microglobulin measured by immunonephelometry: expression patterns and reference intervals in healthy adults
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Zoltán Mátrai
Veröffentlicht/Copyright:
1. Mai 2009
Abstract
Background: Serum β2-microglobulin (β2m) has been established as a marker of disease activity in malignancies, autoimmune conditions and infections. Despite its important role in prognosis assessment and disease monitoring, relatively few studies are available on its expression in healthy individuals. Furthermore, interpretation of results is hampered by the variety in reference limits due to differences in methodology, sample population and statistics.
Methods: Serum β2m concentrations were measured using a microparticle-enhanced immunonephelometric method in 183 healthy blood donors aged 29–75 years.
Results: The median β2m concentration was 1.67 (0.88–2.75) mg/L with no difference between men and women (1.71 mg/L vs. 1.62 mg/L, p<0.07). A linear correlation was found between β2m and age (p<0.0001), serum concentrations significantly higher in older subjects (1.55, 1.59, 1.70, and 1.87 mg/L in age groups of 29–40, 40–50, 50–60 and 60–75 years, respectively, p<0.0001). Reference intervals obtained by non-parametric estimation after partitioning by age were 1.02–2.46 mg/L vs. 1.29–2.70 mg/L in younger (29–49 years) vs. older (50–75 years) individuals.
Conclusions: These data can help standardise β2m reference limits and support age-adjusted comparisons in clinical studies.
Clin Chem Lab Med 2009;47:585–9.
Received: 2009-1-24
Accepted: 2009-3-10
Published Online: 2009-05-01
Published in Print: 2009-05-01
©2009 by Walter de Gruyter Berlin New York
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Schlagwörter für diesen Artikel
age;
β2-microglobulin (β2m);
immunonephelometry;
reference interval;
serum
Artikel in diesem Heft
- Review
- Pharmacogenetics of vitamin K antagonists: useful or hype?
- Genetics and Molecular Diagnostics
- Illumina DNA test panel-based genotyping of whole genome amplified-DNA extracted from hair samples: performance and agreement with genotyping results from genomic DNA from buccal cells
- Association of interleukin-18 gene promoter polymorphisms with risk of acute myocardial infarction in northern Chinese Han population
- MYC quantitation in cell-free plasma DNA by real-time PCR for gastric cancer diagnosis
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- General Clinical Chemistry and Laboratory Medicine
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