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Association of interleukin-18 gene promoter polymorphisms with risk of acute myocardial infarction in northern Chinese Han population
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Fang Pei
Published/Copyright:
March 24, 2009
Abstract
Background: Interleukin-18 (IL-18) has been suggested to play an important role in coronary arterial disease and its sequelae. The aim of the present study was to investigate the association between IL-18 promoter functional polymorphisms (−607C/A and −137G/C) and acute myocardial infarction (AMI) in northern Chinese Han population.
Methods: We performed a case-control study including 234 patients with AMI and 216 age- and sex-matched controls. Genotyping was performed using sequence specific primer-polymerase chain reaction (PCR-SSP).
Results: There were significant differences in the genotype and allele distribution of −607C/A polymorphism of the IL-18 gene between cases and controls. Logistic regression analysis with adjustments for other well-established risk factors revealed that the −607C allele carriers had a significantly increased risk of AMI compared with the non-carriers (OR=1.890, 95% CI 1.196–2.985, p=0.006). No relationship between −137G/C polymorphism and AMI was found.
Conclusions: This study shows for the first time that the IL-18 gene promoter −607C/A polymorphism may be considered a genetic risk factor for AMI in northern Chinese Han population.
Clin Chem Lab Med 2009;47:523–9.
Received: 2008-10-6
Accepted: 2009-2-17
Published Online: 2009-03-24
Published in Print: 2009-05-01
©2009 by Walter de Gruyter Berlin New York
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