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Cystatin C: current position and future prospects
-
Sophie Séronie-Vivien
Veröffentlicht/Copyright:
1. Dezember 2008
Abstract
Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal function that could replace creatinine. Indeed, the concentration of cystatin C is mainly determined by glomerular filtration and is particularly of interest in clinical settings where the relationship between creatinine production and muscle mass impairs the clinical performance of creatinine. Since the last decade, numerous studies have evaluated its potential use in measuring renal function in various populations. More recently, other potential developments for its clinical use have emerged. This review summarises current knowledge about the physiology of cystatin C and about its use as a renal marker, either alone or in equations developed to estimate the glomerular filtration rate. This paper also reviews recent data about the other applications of cystatin C, particularly in cardiology, oncology and clinical pharmacology.
Clin Chem Lab Med 2008;46:1664–86.
Keywords: cancer; cardiovascular risk; chronic renal failure; creatinine; cystatin C; glomerular filtration rate
Received: 2008-5-26
Accepted: 2008-8-18
Published Online: 2008-12-01
Published in Print: 2008-12-01
Published in Print: 2008-10-31
©2008 by Walter de Gruyter Berlin New York
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Artikel in diesem Heft
- Editors' and Publisher's Note
- CCLM Award for the most cited paper recently published
- Reviews
- Cystatin C: current position and future prospects
- Some heterogeneity factors affecting the B-type natriuretic peptides outcome: a meta-analysis
- Genetics and Molecular Diagnostics
- Effect of cyclin D1 (CCND1) polymorphism on gastric premalignant condition
- Identification of two de novo mutations in Chinese patients with X-linked adrenoleukodystrophy
- CYP21A2 gene mutation analysis in Moroccan patients with classic form of 21-hydroxylase deficiency: high regional prevalence of p.Q318X mutation and identification of a novel p.L353R mutation
- Apolipoprotein A5 gene −1131T/C polymorphism is associated with the risk of metabolic syndrome in ethnic Chinese in Taiwan
- Association of GSTM1 and GSTT1 gene polymorphisms with coronary artery disease in relation to tobacco smoking
- Use of the biochip microarray system in detection of myocardial injury caused by radiofrequency catheter ablation
- An in-house method for the detection and quantification of HCV in serum samples using a TaqMan assay real time PCR approach
- General Clinical Chemistry and Laboratory Medicine
- Drugs and brain death diagnostics: determination of drugs capable of inducing EEG zero line
- Accurate assessment and identification of naturally occurring cellular cobalamins
- Development and validation of a high-performance liquid chromatography assay for posaconazole utilizing solid-phase extraction
- Discriminant value of % microcytic/% hypochromic ratio in the differential diagnosis of microcytic anemia
- Determination of carbohydrate-deficient transferrin (CDT) in Italy
- Validation and Outcome Studies
- Critical evaluation of connectivity-based point of care testing systems of glucose in a hospital environment
- Validation of a novel ELISA for measurement of electronegative low-density lipoprotein
- Five commercially available insulin-like growth factor I (IGF-I) assays in comparison to the former Nichols Advantage IGF-I in a growth hormone treated population
- Introduction of non-linearity by data transformation in method comparison and commutability studies
- Reliability and correlation study of a new homocysteine assay
- Letters to the Editor
- Prevention of preanalytical false-positive increases of cardiac troponin I on the Unicel® DxI 800 analyzer
- Does carbamylated hemoglobin still affect the analysis of HbA1c in uremic and hyperglycemic patients?
- Recombinant immunoblot for assessment of intrathecally synthesised paraneoplastic antineuronal antibodies in cerebrospinal fluid from patients with paraneoplastic neurological syndromes
- Detection of duplicates and redundancies. A major responsibility of peer-reviewers?
- Erratum
- Diagnostic performance of rapid tests for detection of fecal calprotectin and lactoferrin and their ability to discriminate inflammatory from irritable bowel syndrome
- Acknowledgement
- Acknowledgements
- Contents
- Contents, Volume 46, 2008
- Author Index
- Author Index
- Subject Index
- Subject Index
Schlagwörter für diesen Artikel
cancer;
cardiovascular risk;
chronic renal failure;
creatinine;
cystatin C;
glomerular filtration rate
Artikel in diesem Heft
- Editors' and Publisher's Note
- CCLM Award for the most cited paper recently published
- Reviews
- Cystatin C: current position and future prospects
- Some heterogeneity factors affecting the B-type natriuretic peptides outcome: a meta-analysis
- Genetics and Molecular Diagnostics
- Effect of cyclin D1 (CCND1) polymorphism on gastric premalignant condition
- Identification of two de novo mutations in Chinese patients with X-linked adrenoleukodystrophy
- CYP21A2 gene mutation analysis in Moroccan patients with classic form of 21-hydroxylase deficiency: high regional prevalence of p.Q318X mutation and identification of a novel p.L353R mutation
- Apolipoprotein A5 gene −1131T/C polymorphism is associated with the risk of metabolic syndrome in ethnic Chinese in Taiwan
- Association of GSTM1 and GSTT1 gene polymorphisms with coronary artery disease in relation to tobacco smoking
- Use of the biochip microarray system in detection of myocardial injury caused by radiofrequency catheter ablation
- An in-house method for the detection and quantification of HCV in serum samples using a TaqMan assay real time PCR approach
- General Clinical Chemistry and Laboratory Medicine
- Drugs and brain death diagnostics: determination of drugs capable of inducing EEG zero line
- Accurate assessment and identification of naturally occurring cellular cobalamins
- Development and validation of a high-performance liquid chromatography assay for posaconazole utilizing solid-phase extraction
- Discriminant value of % microcytic/% hypochromic ratio in the differential diagnosis of microcytic anemia
- Determination of carbohydrate-deficient transferrin (CDT) in Italy
- Validation and Outcome Studies
- Critical evaluation of connectivity-based point of care testing systems of glucose in a hospital environment
- Validation of a novel ELISA for measurement of electronegative low-density lipoprotein
- Five commercially available insulin-like growth factor I (IGF-I) assays in comparison to the former Nichols Advantage IGF-I in a growth hormone treated population
- Introduction of non-linearity by data transformation in method comparison and commutability studies
- Reliability and correlation study of a new homocysteine assay
- Letters to the Editor
- Prevention of preanalytical false-positive increases of cardiac troponin I on the Unicel® DxI 800 analyzer
- Does carbamylated hemoglobin still affect the analysis of HbA1c in uremic and hyperglycemic patients?
- Recombinant immunoblot for assessment of intrathecally synthesised paraneoplastic antineuronal antibodies in cerebrospinal fluid from patients with paraneoplastic neurological syndromes
- Detection of duplicates and redundancies. A major responsibility of peer-reviewers?
- Erratum
- Diagnostic performance of rapid tests for detection of fecal calprotectin and lactoferrin and their ability to discriminate inflammatory from irritable bowel syndrome
- Acknowledgement
- Acknowledgements
- Contents
- Contents, Volume 46, 2008
- Author Index
- Author Index
- Subject Index
- Subject Index
