Startseite Association of GSTM1 and GSTT1 gene polymorphisms with coronary artery disease in relation to tobacco smoking
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Association of GSTM1 and GSTT1 gene polymorphisms with coronary artery disease in relation to tobacco smoking

  • Lian-Sheng Wang , Jian-Jin Tang , Na-Ping Tang , Min-Wei Wang , Jian-Jun Yan , Qi-Min Wang , Zhi-Jian Yang und Bin Wang
Veröffentlicht/Copyright: 1. Dezember 2008
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Clinical Chemistry and Laboratory Medicine
Aus der Zeitschrift Clinical Chemistry and Laboratory Medicine Band 46 Heft 12

Abstract

Background: Recent studies suggest that the common variant in the glutathione S-transferase (GST) M1 (GSTM1) and T1 (GSTT1) gene is associated with the risk of smoking-related coronary artery disease (CAD). Intra-ethnic as well as inter-ethnic differences are known to impact the frequencies of GST gene polymorphisms, thus influencing its interactive effect with tobacco smoking on CAD risk. The aim of the present study was to evaluate the interaction of the genetic polymorphisms of GSTM1 and GSTT1 with cigarette smoking and the risk of CAD in a Chinese population.

Methods: We conducted a study with 277 CAD patients and 277 controls matched by age and sex to examine the prevalence of GSTM1 and GSTT1 polymorphism in CAD.

Results: We found that homozygous deletion of GSTM1 had a frequency of 32.1% among patients with CAD and 21.3% among those without CAD (p=0.004). The frequency of the GSTT1null genotype was 27.8% among the patients with CAD and 19.1% among CAD-free subjects (p=0.016). Patients who smoked having both the wild-type genotypes of GSTM1 and GSTT1 were protected from developing coronary heart disease (p<0.001). Moreover, smokers with combined GSTM1nullGSTT1null genotypes had a significantly higher number of stenosed vessels than those with the positive genotype (p=0.02).

Conclusions: Our results suggest that GST polymorphisms may be a susceptibility factor to smoking-related CAD in the Chinese population.

Clin Chem Lab Med 2008;46:1720–5.

Keywords: coronary artery disease; DNA damage; glutathione S-transferase gene polymorphisms; smoking
a

Drs. L.S. Wang, J.J. Tang and N.P. Tang contributed equally to this work.

Corresponding authors: Bin Wang, PhD, Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, Jiangsu Province, China Phone/Fax: +86-25-86862884, Lian-Sheng Wang, MD, PhD, Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu Province, China Phone/Fax: +86-25-83724440,
Received: 2008-6-3
Accepted: 2008-9-1
Published Online: 2008-12-01
Published in Print: 2008-12-01

©2008 by Walter de Gruyter Berlin New York

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https://doi.org/10.1515/CCLM.2008.353
Schlagwörter für diesen Artikel
coronary artery disease; DNA damage; glutathione S-transferase gene polymorphisms; smoking

Artikel in diesem Heft

  1. Editors' and Publisher's Note
  2. CCLM Award for the most cited paper recently published
  3. Reviews
  4. Cystatin C: current position and future prospects
  5. Some heterogeneity factors affecting the B-type natriuretic peptides outcome: a meta-analysis
  6. Genetics and Molecular Diagnostics
  7. Effect of cyclin D1 (CCND1) polymorphism on gastric premalignant condition
  8. Identification of two de novo mutations in Chinese patients with X-linked adrenoleukodystrophy
  9. CYP21A2 gene mutation analysis in Moroccan patients with classic form of 21-hydroxylase deficiency: high regional prevalence of p.Q318X mutation and identification of a novel p.L353R mutation
  10. Apolipoprotein A5 gene −1131T/C polymorphism is associated with the risk of metabolic syndrome in ethnic Chinese in Taiwan
  11. Association of GSTM1 and GSTT1 gene polymorphisms with coronary artery disease in relation to tobacco smoking
  12. Use of the biochip microarray system in detection of myocardial injury caused by radiofrequency catheter ablation
  13. An in-house method for the detection and quantification of HCV in serum samples using a TaqMan assay real time PCR approach
  14. General Clinical Chemistry and Laboratory Medicine
  15. Drugs and brain death diagnostics: determination of drugs capable of inducing EEG zero line
  16. Accurate assessment and identification of naturally occurring cellular cobalamins
  17. Development and validation of a high-performance liquid chromatography assay for posaconazole utilizing solid-phase extraction
  18. Discriminant value of % microcytic/% hypochromic ratio in the differential diagnosis of microcytic anemia
  19. Determination of carbohydrate-deficient transferrin (CDT) in Italy
  20. Validation and Outcome Studies
  21. Critical evaluation of connectivity-based point of care testing systems of glucose in a hospital environment
  22. Validation of a novel ELISA for measurement of electronegative low-density lipoprotein
  23. Five commercially available insulin-like growth factor I (IGF-I) assays in comparison to the former Nichols Advantage IGF-I in a growth hormone treated population
  24. Introduction of non-linearity by data transformation in method comparison and commutability studies
  25. Reliability and correlation study of a new homocysteine assay
  26. Letters to the Editor
  27. Prevention of preanalytical false-positive increases of cardiac troponin I on the Unicel® DxI 800 analyzer
  28. Does carbamylated hemoglobin still affect the analysis of HbA1c in uremic and hyperglycemic patients?
  29. Recombinant immunoblot for assessment of intrathecally synthesised paraneoplastic antineuronal antibodies in cerebrospinal fluid from patients with paraneoplastic neurological syndromes
  30. Detection of duplicates and redundancies. A major responsibility of peer-reviewers?
  31. Erratum
  32. Diagnostic performance of rapid tests for detection of fecal calprotectin and lactoferrin and their ability to discriminate inflammatory from irritable bowel syndrome
  33. Acknowledgement
  34. Acknowledgements
  35. Contents
  36. Contents, Volume 46, 2008
  37. Author Index
  38. Author Index
  39. Subject Index
  40. Subject Index
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