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Apolipoprotein A5 gene −1131T/C polymorphism is associated with the risk of metabolic syndrome in ethnic Chinese in Taiwan

  • Lung-An Hsu , Yu-Lin Ko , Chi-Jen Chang , Ming-Sheng Teng , Semon Wu and Chiao-Feng Hu
Published/Copyright: December 1, 2008
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Clinical Chemistry and Laboratory Medicine
From the journal Clinical Chemistry and Laboratory Medicine Volume 46 Issue 12

Abstract

Background: The –1131T>C polymorphism in the apolipoprotein gene A5 (APOA5) was found to be associated with increased levels of plasma triglyceride and decreased levels of high-density lipoprotein cholesterol (HDL-C), which are characteristic dyslipidemic components of metabolic syndrome. This study aimed to identify a link between this polymorphism and the risk of metabolic syndrome.

Methods: The sample population comprised 615 unrelated subjects, 18.7% of whom had metabolic syndrome. Genotypes were determined via polymerase chain reaction, restriction mapping with MseI, and gel electrophoresis.

Results: A significantly higher level of triglycerides and a lower level of HDL-C were noted in carriers of the –1131C allele than in the non-carriers (p<0.001 and p=0.044, respectively). The frequency of the –1131C allele in the metabolic syndrome-affected subjects was significantly higher than that of the group of unaffected subjects (37.4% vs. 27.7%, p=0.004). Even after adjusting for age, gender, smoking, regular exercise, and waist-to-hip ratio, the APOA5–1131C allele carriers remained significantly associated with an increased risk of metabolic syndrome (OR=1.77, 95% CI, 1.13–2.77; p=0.012).

Conclusions: These results indicate that the association of APOA5 –1131T>C polymorphism with dyslipidemia can also contribute to an increased susceptibility to metabolic syndrome in the Chinese, as a result of its effect on triglyceride metabolism.

Clin Chem Lab Med 2008;46:1714–9.

Keywords: APOA5; high-density lipoprotein cholesterol; metabolic syndrome; polymorphism; triglycerides
Corresponding author: Lung-An Hsu, MD, PhD, Department of Internal Medicine, The First Cardiovascular Division, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No. 199, Tung-Hwa North Road, Taipei, Taiwan Phone: +886-3-3281200 ext. 8162, Fax: +886-3-3271192,
Received: 2008-6-16
Accepted: 2008-8-26
Published Online: 2008-12-01
Published in Print: 2008-12-01

©2008 by Walter de Gruyter Berlin New York

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https://doi.org/10.1515/CCLM.2008.352
Keywords for this article
APOA5; high-density lipoprotein cholesterol; metabolic syndrome; polymorphism; triglycerides

Articles in the same Issue

  1. Editors' and Publisher's Note
  2. CCLM Award for the most cited paper recently published
  3. Reviews
  4. Cystatin C: current position and future prospects
  5. Some heterogeneity factors affecting the B-type natriuretic peptides outcome: a meta-analysis
  6. Genetics and Molecular Diagnostics
  7. Effect of cyclin D1 (CCND1) polymorphism on gastric premalignant condition
  8. Identification of two de novo mutations in Chinese patients with X-linked adrenoleukodystrophy
  9. CYP21A2 gene mutation analysis in Moroccan patients with classic form of 21-hydroxylase deficiency: high regional prevalence of p.Q318X mutation and identification of a novel p.L353R mutation
  10. Apolipoprotein A5 gene −1131T/C polymorphism is associated with the risk of metabolic syndrome in ethnic Chinese in Taiwan
  11. Association of GSTM1 and GSTT1 gene polymorphisms with coronary artery disease in relation to tobacco smoking
  12. Use of the biochip microarray system in detection of myocardial injury caused by radiofrequency catheter ablation
  13. An in-house method for the detection and quantification of HCV in serum samples using a TaqMan assay real time PCR approach
  14. General Clinical Chemistry and Laboratory Medicine
  15. Drugs and brain death diagnostics: determination of drugs capable of inducing EEG zero line
  16. Accurate assessment and identification of naturally occurring cellular cobalamins
  17. Development and validation of a high-performance liquid chromatography assay for posaconazole utilizing solid-phase extraction
  18. Discriminant value of % microcytic/% hypochromic ratio in the differential diagnosis of microcytic anemia
  19. Determination of carbohydrate-deficient transferrin (CDT) in Italy
  20. Validation and Outcome Studies
  21. Critical evaluation of connectivity-based point of care testing systems of glucose in a hospital environment
  22. Validation of a novel ELISA for measurement of electronegative low-density lipoprotein
  23. Five commercially available insulin-like growth factor I (IGF-I) assays in comparison to the former Nichols Advantage IGF-I in a growth hormone treated population
  24. Introduction of non-linearity by data transformation in method comparison and commutability studies
  25. Reliability and correlation study of a new homocysteine assay
  26. Letters to the Editor
  27. Prevention of preanalytical false-positive increases of cardiac troponin I on the Unicel® DxI 800 analyzer
  28. Does carbamylated hemoglobin still affect the analysis of HbA1c in uremic and hyperglycemic patients?
  29. Recombinant immunoblot for assessment of intrathecally synthesised paraneoplastic antineuronal antibodies in cerebrospinal fluid from patients with paraneoplastic neurological syndromes
  30. Detection of duplicates and redundancies. A major responsibility of peer-reviewers?
  31. Erratum
  32. Diagnostic performance of rapid tests for detection of fecal calprotectin and lactoferrin and their ability to discriminate inflammatory from irritable bowel syndrome
  33. Acknowledgement
  34. Acknowledgements
  35. Contents
  36. Contents, Volume 46, 2008
  37. Author Index
  38. Author Index
  39. Subject Index
  40. Subject Index
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