Effect of cyclin D1 (CCND1) polymorphism on gastric premalignant condition
-
Tomomitsu Tahara
Abstract
Background: Cyclin D1 (CCND1) is known to regulate function in G1 arrest and therefore may play an important role in carcinogenesis. The aim of this study was to investigate the effect of G870A polymorphism of the CCND1 gene on gastric precancerous condition, on histological chronic gastritis, and on the risk of peptic ulcer diseases.
Methods: Restriction fragment length polymorphism analysis was performed for polymorphisms at 870GA in the CCND1 gene in 524 cancer-free subjects, including 111 gastric and 54 duodenal ulcers, and 359 non-ulcer subjects. Gastritis scores of antral gastric mucosa were assessed according to the updated Sydney system in 384 subjects.
Results: CCND1 genotype was significantly associated with the severity of intestinal metaplasia by the Kruskal-Wallis test, and this tendency was especially stronger among older subjects of 61 years or older (overall subjects: p=0.035, 61 years∼: p=0.007). We also found that the 870AA genotype held a significant high risk of intestinal metaplasia [Helicobacter pylori infection adjusted odds ratio (OR)=1.8, 95% confidence interval (CI)=1.03–3.15, p=0.04]. The same genotype was more closely associated with the risk of intestinal metaplasia in older subjects of 61 years or older (H. pylori infection adjusted OR=3.45, 95% CI=1.48–8.08, p=0.004). A non-significant association was found between CCND1 G870A genotypes and the risk of peptic ulcer diseases as well as histological severity of acute or chronic inflammation.
Conclusions: It appears that the G870A polymorphism of CCND1 is associated with gastric premalignant condition especially in older subjects.
Clin Chem Lab Med 2008;46:1696–701.
©2008 by Walter de Gruyter Berlin New York
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- Contents
- Contents, Volume 46, 2008
- Author Index
- Author Index
- Subject Index
- Subject Index
Articles in the same Issue
- Editors' and Publisher's Note
- CCLM Award for the most cited paper recently published
- Reviews
- Cystatin C: current position and future prospects
- Some heterogeneity factors affecting the B-type natriuretic peptides outcome: a meta-analysis
- Genetics and Molecular Diagnostics
- Effect of cyclin D1 (CCND1) polymorphism on gastric premalignant condition
- Identification of two de novo mutations in Chinese patients with X-linked adrenoleukodystrophy
- CYP21A2 gene mutation analysis in Moroccan patients with classic form of 21-hydroxylase deficiency: high regional prevalence of p.Q318X mutation and identification of a novel p.L353R mutation
- Apolipoprotein A5 gene −1131T/C polymorphism is associated with the risk of metabolic syndrome in ethnic Chinese in Taiwan
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- An in-house method for the detection and quantification of HCV in serum samples using a TaqMan assay real time PCR approach
- General Clinical Chemistry and Laboratory Medicine
- Drugs and brain death diagnostics: determination of drugs capable of inducing EEG zero line
- Accurate assessment and identification of naturally occurring cellular cobalamins
- Development and validation of a high-performance liquid chromatography assay for posaconazole utilizing solid-phase extraction
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- Erratum
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- Acknowledgement
- Acknowledgements
- Contents
- Contents, Volume 46, 2008
- Author Index
- Author Index
- Subject Index
- Subject Index
