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Global standardization of glycated hemoglobin measurement: the position of the IFCC Working Group
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International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) IFCC Scientific Division, Working Group on Standardization of HbA1c (WG-HbA1c): Andrea Mosca
Veröffentlicht/Copyright:
9. August 2007
Abstract
The measurement of glycated hemoglobin is central in the monitoring of glycemic control in patients with diabetes. There are at least 30 different laboratory assays commercially available to measure the proportion of HbA1c in blood. In 1995 the IFCC established a Working Group (IFCC WG-HbA1c) to achieve international standardization of HbA1c measurement. The main achievements can be summarized as follows: a) a reference measurement procedure has been established with purified primary calibrators; b) a network of reference laboratories has been developed worldwide; and c) work has begun on implementation of traceability to the IFCC reference system. The IFCC WG-HbA1c recognizes the recommendation of the IFCC-IUPAC Committee on Nomenclature, Properties and Units that the analyte measured by the IFCC reference measurement procedure has been defined as βN1-deoxyfructosyl-hemoglobin and that the recommended measurement units are mmol/mol. The IFCC WG-HbA1c recommends maintaining the use of the name HbA1c in clinical practice.
Clin Chem Lab Med 2007;45:1077–80.
Published Online: 2007-08-09
Published in Print: 2007-08-01
©2007 by Walter de Gruyter Berlin New York
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Schlagwörter für diesen Artikel
diabetes;
glycated hemoglobin;
HbA1c;
network;
reference methods;
standardization
Artikel in diesem Heft
- Congress of Clinical Chemistry and Laboratory Medicine, Joint Annual Congress of The Austrian Society for Laboratory Medicine and Clinical Chemistry (OEGLMKC) and the The German United Society of Clinical Chemistry and Laboratory Medicine (DGKL), Vienna, Austria, September 19-22, 2007
- Interpretation of laboratory results: the Reference Intervals, a necessary evil?
- Implementation of haemoglobin A1c results traceable to the IFCC reference system: the way forward
- Exhaled breath condensate: a new method for lung disease diagnosis
- Biochemical markers of alcoholism
- Polymorphisms of the peroxisome proliferator-activated receptor-γ coactivator-1α gene are associated with hypertrophic cardiomyopathy and not with hypertension hypertrophy
- Association of interleukin-1 genetic polymorphisms with the risk of rheumatoid arthritis in Chinese population
- Highest accuracy of combined consensus clinical criteria and SNRPN gene molecular markers in diagnosis of Prader-Willi syndrome in Thai patients
- Use of maternal plasma for non-invasive prenatal diagnosis of fetal ABO genotypes
- Relationship of the CAG repeat polymorphism of the MEF2A gene and coronary artery disease in a Chinese population
- Specific real-time PCR vs. fluorescent dyes for serum free DNA quantification
- Increased glycation of hemoglobin and plasma proteins in normotensive, non-diabetic obese Indian subjects: putative role of lipid peroxides
- The relationship between red blood cell and reticulocyte indices and serum markers of iron status in the cord blood of newborns
- Association of amino-terminal propeptide of type III procollagen and acute myocardial rejection in male patients receiving heart transplantation
- Changes in platelet count and indices in pulmonary tuberculosis
- Activity or mass concentration of bone-specific alkaline phosphatase as a marker of bone formation
- A simple isocratic HPLC assay to determine linezolid concentrations in different biomatrices for in vivo and in vitro studies
- Pitfalls in measuring the endocannabinoid 2-arachidonoyl glycerol in biological samples
- Partitioning reference values for several subpopulations using cluster analysis
- A plea for intra-laboratory reference limits. Part 1. General considerations and concepts for determination
- A plea for intra-laboratory reference limits. Part 2. A bimodal retrospective concept for determining reference limits from intra-laboratory databases demonstrated by catalytic activity concentrations of enzymes
- Biological variation of thyroid autoantibodies and thyroglobulin
- Monitoring glycaemic control: is there evidence for appropriate use of routine measurement of glycated haemoglobin?
- Performance and utility of a cost-effective collagen-binding assay for the laboratory diagnosis of Von Willebrand disease
- Hook effect in calcitonin immunoradiometric assay
- Rapid genotyping of the Ser447Stop variant of the lipoprotein lipase gene using real-time fluorescent PCR
- Global standardization of glycated hemoglobin measurement: the position of the IFCC Working Group
- Recommendation for term and measurement unit for “HbA1c”
- Desirable performance standards for HbA1c analysis – precision, accuracy and standardisation Consensus statement of the Australasian Association of Clinical Biochemists (AACB), the Australian Diabetes Society (ADS), the Royal College of Pathologists of Australasia (RCPA), Endocrine Society of Australia (ESA), and the Australian Diabetes Educators Association (ADEA)
- IFCC Position Paper: Report of the IFCC Taskforce on Ethics: Introduction and framework
- IFCC Awards: Call for Nominations
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