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Association of interleukin-1 genetic polymorphisms with the risk of rheumatoid arthritis in Chinese population
-
Chong-ge You
Veröffentlicht/Copyright:
9. August 2007
Abstract
Background: Previous studies suggest that a variable number of tandem repeats polymorphism in the second intron of the interleukin-1 receptor antagonist gene and two single nucleotide polymorphisms at positions −511 and +3954 of the interleukin-1β (IL-1B) gene are associated with an increased risk of autoimmune diseases. In the present study, we evaluated associations between these genetic factors and an increased risk of rheumatoid arthritis (RA) in a population from Northwest China.
Methods: A total of 240 patients with RA and 227 healthy controls from Northwest China were investigated using PCR and PCR-restriction fragment length polymorphism. Genotype and allele distributions and haplotype construction were analyzed.
Results: The genotype and allele distributions of IL-1B +3954 and IL-1RN polymorphisms were significantly different in RA patients compared to controls (p<0.001 and p<0.001; p=0.028, p=0.023, respectively). Significant differences were also observed between the RA and control groups for the haplotypes IL-1B–511C/+3954C/IL-1RN *1, IL-1B–511C/+3954T/IL-1RN *1 and IL-1B–511T/+3954T/IL-1RN *1 [p=0.017, odds ratio (OR) 0.721, 95% confidence interval (CI) 0.551–0.944; p=0.030, OR 2.111, 95% CI 1.060–4.204; and p=0.029, OR 2.909, 95% CI 1.066–7.902, respectively].
Conclusions: These findings suggest that IL-1B +3954 and IL-1RN genetic polymorphisms are associated with a significantly increased risk of RA in this Chinese population.
Clin Chem Lab Med 2007;45:968–71.
Received: 2006-11-27
Accepted: 2007-2-21
Published Online: 2007-08-09
Published in Print: 2007-08-01
©2007 by Walter de Gruyter Berlin New York
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Schlagwörter für diesen Artikel
haplotype;
interleukin-1β;
interleukin-1 receptor antagonist;
rheumatoid arthritis
Artikel in diesem Heft
- Congress of Clinical Chemistry and Laboratory Medicine, Joint Annual Congress of The Austrian Society for Laboratory Medicine and Clinical Chemistry (OEGLMKC) and the The German United Society of Clinical Chemistry and Laboratory Medicine (DGKL), Vienna, Austria, September 19-22, 2007
- Interpretation of laboratory results: the Reference Intervals, a necessary evil?
- Implementation of haemoglobin A1c results traceable to the IFCC reference system: the way forward
- Exhaled breath condensate: a new method for lung disease diagnosis
- Biochemical markers of alcoholism
- Polymorphisms of the peroxisome proliferator-activated receptor-γ coactivator-1α gene are associated with hypertrophic cardiomyopathy and not with hypertension hypertrophy
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- Highest accuracy of combined consensus clinical criteria and SNRPN gene molecular markers in diagnosis of Prader-Willi syndrome in Thai patients
- Use of maternal plasma for non-invasive prenatal diagnosis of fetal ABO genotypes
- Relationship of the CAG repeat polymorphism of the MEF2A gene and coronary artery disease in a Chinese population
- Specific real-time PCR vs. fluorescent dyes for serum free DNA quantification
- Increased glycation of hemoglobin and plasma proteins in normotensive, non-diabetic obese Indian subjects: putative role of lipid peroxides
- The relationship between red blood cell and reticulocyte indices and serum markers of iron status in the cord blood of newborns
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- A plea for intra-laboratory reference limits. Part 2. A bimodal retrospective concept for determining reference limits from intra-laboratory databases demonstrated by catalytic activity concentrations of enzymes
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- Monitoring glycaemic control: is there evidence for appropriate use of routine measurement of glycated haemoglobin?
- Performance and utility of a cost-effective collagen-binding assay for the laboratory diagnosis of Von Willebrand disease
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