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Association of amino-terminal propeptide of type III procollagen and acute myocardial rejection in male patients receiving heart transplantation
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Yen-Hung Lin
Published/Copyright:
August 9, 2007
Abstract
Background: The amino-terminal propeptides of type I and III procollagens (PINP and PIIINP) are markers reflecting the status of collagen turnover. We hypothesized that measurement of these serum procollagen propeptides could be used to non-invasively assess acute rejection in heart transplant recipients.
Methods: In heart transplant recipients, endomyocardial biopsy specimens taken at 6 and 12 months after surgery were used for study. PINP and PIIINP were measured postoperatively at 3, 6, and 12 months.
Results: A total of 20 male heart transplant patients and seven male control subjects were enrolled. Five patients showed rejection 6 months after transplantation (group 1), while 15 patients showed no rejection (group 2). In group 2 patients, serum PINP and PIIINP levels decreased significantly 6 months after transplantation. In contrast, elevation of serum PINP and PIIINP levels persisted in group 1 patients 6 months after transplantation. At 6 months after transplantation, group 1 patients had significantly higher PIIINP levels than group 2 patients (p=0.025) and controls (p=0.003). After immunosuppressive therapy, all group 1 patients were free of rejection 12 months after transplantation and serial serum PIIINP levels decreased significantly in these patients.
Conclusions: Serum PIIINP levels represent a non-invasive method to reflect the occurrence and resolution of acute rejection.
Clin Chem Lab Med 2007;45:1004–8.
Keywords: amino-terminal propeptide of type I procollagen; amino-terminal propeptide of type III procollagen; heart transplantation; rejection
Received: 2007-2-26
Accepted: 2007-5-3
Published Online: 2007-08-09
Published in Print: 2007-08-01
©2007 by Walter de Gruyter Berlin New York
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Keywords for this article
amino-terminal propeptide of type I procollagen;
amino-terminal propeptide of type III procollagen;
heart transplantation;
rejection
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