Artikel
Lizenziert
Nicht lizenziert
Erfordert eine Authentifizierung
Increased glycation of hemoglobin and plasma proteins in normotensive, non-diabetic obese Indian subjects: putative role of lipid peroxides
-
Viswanathan Sathiyapriya
Veröffentlicht/Copyright:
1. August 2007
Abstract
Background: Glycation and lipid peroxidation are spontaneous reactions believed to contribute to the pathogenesis of many clinical disorders. The purpose of the present study was to evaluate the levels of lipid peroxides and glycated proteins in normotensive, non-diabetic obese Indian subjects and to assess possible associations between them.
Methods: A total of 28 obese male subjects and 20 non-obese subjects were included in the present study. Whole blood glycated hemoglobin, plasma lipid peroxides and fructosamine levels were estimated in both groups.
Results: Lipid peroxides, glycated hemoglobin and fructosamine levels were significantly higher in obese subjects in comparison with non-obese subjects. We also found a significant association between malondialdehyde and body mass index (r=0.424, p=0.025). Partial correlation analysis revealed that malondialdehyde was significantly correlated with glycated hemoglobin (r=0.590, p=0.01) and fructosamine (r=0.442, p=0.021) after controlling for glucose.
Conclusions: Increased glycation of proteins was found in normotensive, non-diabetic obese Indian subjects. These data also support the premise that lipid peroxides per se play a role in the glycation of hemoglobin and plasma proteins.
Clin Chem Lab Med 2007;45:996–9.
Received: 2006-11-23
Accepted: 2007-4-10
Published Online: 2007-08-01
Published in Print: 2007-08-01
©2007 by Walter de Gruyter Berlin New York
Sie haben derzeit keinen Zugang zu diesem Inhalt.
Sie haben derzeit keinen Zugang zu diesem Inhalt.
Artikel in diesem Heft
- Congress of Clinical Chemistry and Laboratory Medicine, Joint Annual Congress of The Austrian Society for Laboratory Medicine and Clinical Chemistry (OEGLMKC) and the The German United Society of Clinical Chemistry and Laboratory Medicine (DGKL), Vienna, Austria, September 19-22, 2007
- Interpretation of laboratory results: the Reference Intervals, a necessary evil?
- Implementation of haemoglobin A1c results traceable to the IFCC reference system: the way forward
- Exhaled breath condensate: a new method for lung disease diagnosis
- Biochemical markers of alcoholism
- Polymorphisms of the peroxisome proliferator-activated receptor-γ coactivator-1α gene are associated with hypertrophic cardiomyopathy and not with hypertension hypertrophy
- Association of interleukin-1 genetic polymorphisms with the risk of rheumatoid arthritis in Chinese population
- Highest accuracy of combined consensus clinical criteria and SNRPN gene molecular markers in diagnosis of Prader-Willi syndrome in Thai patients
- Use of maternal plasma for non-invasive prenatal diagnosis of fetal ABO genotypes
- Relationship of the CAG repeat polymorphism of the MEF2A gene and coronary artery disease in a Chinese population
- Specific real-time PCR vs. fluorescent dyes for serum free DNA quantification
- Increased glycation of hemoglobin and plasma proteins in normotensive, non-diabetic obese Indian subjects: putative role of lipid peroxides
- The relationship between red blood cell and reticulocyte indices and serum markers of iron status in the cord blood of newborns
- Association of amino-terminal propeptide of type III procollagen and acute myocardial rejection in male patients receiving heart transplantation
- Changes in platelet count and indices in pulmonary tuberculosis
- Activity or mass concentration of bone-specific alkaline phosphatase as a marker of bone formation
- A simple isocratic HPLC assay to determine linezolid concentrations in different biomatrices for in vivo and in vitro studies
- Pitfalls in measuring the endocannabinoid 2-arachidonoyl glycerol in biological samples
- Partitioning reference values for several subpopulations using cluster analysis
- A plea for intra-laboratory reference limits. Part 1. General considerations and concepts for determination
- A plea for intra-laboratory reference limits. Part 2. A bimodal retrospective concept for determining reference limits from intra-laboratory databases demonstrated by catalytic activity concentrations of enzymes
- Biological variation of thyroid autoantibodies and thyroglobulin
- Monitoring glycaemic control: is there evidence for appropriate use of routine measurement of glycated haemoglobin?
- Performance and utility of a cost-effective collagen-binding assay for the laboratory diagnosis of Von Willebrand disease
- Hook effect in calcitonin immunoradiometric assay
- Rapid genotyping of the Ser447Stop variant of the lipoprotein lipase gene using real-time fluorescent PCR
- Global standardization of glycated hemoglobin measurement: the position of the IFCC Working Group
- Recommendation for term and measurement unit for “HbA1c”
- Desirable performance standards for HbA1c analysis – precision, accuracy and standardisation Consensus statement of the Australasian Association of Clinical Biochemists (AACB), the Australian Diabetes Society (ADS), the Royal College of Pathologists of Australasia (RCPA), Endocrine Society of Australia (ESA), and the Australian Diabetes Educators Association (ADEA)
- IFCC Position Paper: Report of the IFCC Taskforce on Ethics: Introduction and framework
- IFCC Awards: Call for Nominations
- Call for papers, ideas and initiatives
Schlagwörter für diesen Artikel
fructosamine;
glycated hemoglobin;
glycation;
lipid peroxides;
obesity
Artikel in diesem Heft
- Congress of Clinical Chemistry and Laboratory Medicine, Joint Annual Congress of The Austrian Society for Laboratory Medicine and Clinical Chemistry (OEGLMKC) and the The German United Society of Clinical Chemistry and Laboratory Medicine (DGKL), Vienna, Austria, September 19-22, 2007
- Interpretation of laboratory results: the Reference Intervals, a necessary evil?
- Implementation of haemoglobin A1c results traceable to the IFCC reference system: the way forward
- Exhaled breath condensate: a new method for lung disease diagnosis
- Biochemical markers of alcoholism
- Polymorphisms of the peroxisome proliferator-activated receptor-γ coactivator-1α gene are associated with hypertrophic cardiomyopathy and not with hypertension hypertrophy
- Association of interleukin-1 genetic polymorphisms with the risk of rheumatoid arthritis in Chinese population
- Highest accuracy of combined consensus clinical criteria and SNRPN gene molecular markers in diagnosis of Prader-Willi syndrome in Thai patients
- Use of maternal plasma for non-invasive prenatal diagnosis of fetal ABO genotypes
- Relationship of the CAG repeat polymorphism of the MEF2A gene and coronary artery disease in a Chinese population
- Specific real-time PCR vs. fluorescent dyes for serum free DNA quantification
- Increased glycation of hemoglobin and plasma proteins in normotensive, non-diabetic obese Indian subjects: putative role of lipid peroxides
- The relationship between red blood cell and reticulocyte indices and serum markers of iron status in the cord blood of newborns
- Association of amino-terminal propeptide of type III procollagen and acute myocardial rejection in male patients receiving heart transplantation
- Changes in platelet count and indices in pulmonary tuberculosis
- Activity or mass concentration of bone-specific alkaline phosphatase as a marker of bone formation
- A simple isocratic HPLC assay to determine linezolid concentrations in different biomatrices for in vivo and in vitro studies
- Pitfalls in measuring the endocannabinoid 2-arachidonoyl glycerol in biological samples
- Partitioning reference values for several subpopulations using cluster analysis
- A plea for intra-laboratory reference limits. Part 1. General considerations and concepts for determination
- A plea for intra-laboratory reference limits. Part 2. A bimodal retrospective concept for determining reference limits from intra-laboratory databases demonstrated by catalytic activity concentrations of enzymes
- Biological variation of thyroid autoantibodies and thyroglobulin
- Monitoring glycaemic control: is there evidence for appropriate use of routine measurement of glycated haemoglobin?
- Performance and utility of a cost-effective collagen-binding assay for the laboratory diagnosis of Von Willebrand disease
- Hook effect in calcitonin immunoradiometric assay
- Rapid genotyping of the Ser447Stop variant of the lipoprotein lipase gene using real-time fluorescent PCR
- Global standardization of glycated hemoglobin measurement: the position of the IFCC Working Group
- Recommendation for term and measurement unit for “HbA1c”
- Desirable performance standards for HbA1c analysis – precision, accuracy and standardisation Consensus statement of the Australasian Association of Clinical Biochemists (AACB), the Australian Diabetes Society (ADS), the Royal College of Pathologists of Australasia (RCPA), Endocrine Society of Australia (ESA), and the Australian Diabetes Educators Association (ADEA)
- IFCC Position Paper: Report of the IFCC Taskforce on Ethics: Introduction and framework
- IFCC Awards: Call for Nominations
- Call for papers, ideas and initiatives
