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Changes in platelet count and indices in pulmonary tuberculosis
-
Ergun Tozkoparan
Veröffentlicht/Copyright:
9. August 2007
Abstract
Background: Recent studies show that platelets have important roles in the immune system. Little is known about the clinical significance of platelet indices. Changes in platelet indices, including platelet distribution width (PDW), mean platelet volume (MPV) and plateletcrit, in pulmonary tuberculosis were investigated.
Methods: Platelet indices were quantified in 82 patients with active tuberculosis and 87 patients with inactive or non-tuberculous disease (controls). Radiological extent of the disease was assessed.
Results: There were significantly higher PDW (40.9±23.5% vs. 27.0±14.5%), MPV (10.05±2.36 vs. 8.83±1.47 fL) and plateletcrit (0.330±0166% vs. 0.266±0.128%) values in the active tuberculosis group, which decreased significantly with anti-tuberculous therapy. Erythrocyte sedimentation rate and plateletcrit showed significant correlation (r=0.54 and r=0.66) with radiological extent of tuberculosis, while PDW and MPV correlations with radiological extent of tuberculosis were also significant but weaker (r=0.31 and r=0.23). In a subpopulation of controls with pneumonia, which leads to acute phase reaction, PDW, MPV and plateletcrit values were significantly lower than in the tuberculosis group.
Conclusions: We suggest that PDW, MPV and plateletcrit change in tuberculosis and that these changes may not reflect only acute phase reaction and disease activity. The potential role of platelet indices in tuberculosis immunopathogenesis remains to be investigated.
Clin Chem Lab Med 2007;45:1009–13.
Keywords: mean platelet volume; plateletcrit; platelet distribution width; platelet indices; tuberculosis
Received: 2007-1-30
Accepted: 2007-4-19
Published Online: 2007-08-09
Published in Print: 2007-08-01
©2007 by Walter de Gruyter Berlin New York
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Schlagwörter für diesen Artikel
mean platelet volume;
plateletcrit;
platelet distribution width;
platelet indices;
tuberculosis
Artikel in diesem Heft
- Congress of Clinical Chemistry and Laboratory Medicine, Joint Annual Congress of The Austrian Society for Laboratory Medicine and Clinical Chemistry (OEGLMKC) and the The German United Society of Clinical Chemistry and Laboratory Medicine (DGKL), Vienna, Austria, September 19-22, 2007
- Interpretation of laboratory results: the Reference Intervals, a necessary evil?
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- Exhaled breath condensate: a new method for lung disease diagnosis
- Biochemical markers of alcoholism
- Polymorphisms of the peroxisome proliferator-activated receptor-γ coactivator-1α gene are associated with hypertrophic cardiomyopathy and not with hypertension hypertrophy
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