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High-workload endurance training may increase serum ischemia-modified albumin concentrations

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Published/Copyright: September 21, 2011
Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Clinical Chemistry and Laboratory Medicine (CCLM) Volume 43 Issue 7

Abstract

The measurement of cardiac troponins has emerged as the biochemical “gold standard” for the diagnosis and management of patients with acute chest pain. However, earlier markers should support investigation strategies, as several patients with acute coronary syndrome might present with non-diagnostic concentrations. Ischemia-modified albumin (IMA), measured by the albumin cobalt binding (ACB) assay, was recently proposed for early detection of myocardial ischemia. To establish the potential influence of endurance training on the diagnostic approach to patients with suspected myocardial injury, cardiac troponin T (cTnT), creatine kinase isoenzyme MB (CK-MB), myoglobin and IMA were evaluated in healthy individuals subjected to different aerobic workloads. The concentrations of both IMA and CK-MB were significantly increased in athletes subjected to high-workload endurance training, whereas the concentration of cTnT and myoglobin was not influenced by physical exercise in the medium term. Taken together, our results demonstrate that demanding aerobic physical activity might influence the generation of IMA, which might be increased in the medium term following high-workload endurance training, while the concentration of other conventional markers of myocardial injury remains non-diagnostic.

Keywords: acute coronary syndrome; acute myocardial infarction; albumin cobalt binding; ischemia-modified albumin; sport
Corresponding author: Giuseppe Lippi, MD, Istituto di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico-Biomediche, Università degli Studi di Verona, Ospedale Policlinico G.B. Rossi, Piazzale Scuro, 10, 37134 Verona, Italy Phone: +39-045-8074516, Fax: +39-045-8201889,

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Received: 2005-3-31
Accepted: 2005-4-29
Published Online: 2011-9-21
Published in Print: 2005-7-1

©2005 by Walter de Gruyter Berlin New York

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https://doi.org/10.1515/CCLM.2005.126
Keywords for this article
acute coronary syndrome; acute myocardial infarction; albumin cobalt binding; ischemia-modified albumin; sport

Articles in the same Issue

  1. Inter-individual variation of inflammatory markers of cardiovascular risks and diseases
  2. “Coelionomics”: towards understanding the molecular pathology of coeliac disease
  3. Gene expression profiling in human cardiovascular disease
  4. A common CYP1B1 polymorphism is associated with 2-OHE1/16-OHE1 urinary estrone ratio
  5. A quantitative RT-PCR method to determine topoisomerase I mRNA levels in human tissue samples
  6. Insulin sensitivity and counter-regulatory hormones in hypothyroidism and during thyroid hormone replacement therapy
  7. Linearity and detection limit in the measurement of serum M-protein with the capillary zone electrophoresis system Capillarys ®
  8. Quantitative measurement of ketone bodies in urine using reflectometry
  9. Quantification of voriconazole in plasma by liquid chromatography-tandem mass spectrometry
  10. Determination of the antioxidant capacity in blood
  11. High-workload endurance training may increase serum ischemia-modified albumin concentrations
  12. Advanced oxidation protein products in serum of patients with myotonic disease type I: association with serum γ-glutamyltransferase and disease severity
  13. Effectiveness of different methods for anti-Sm antibody identification. A multicentre study
  14. Quality control in neutrophil granulocyte (PMN) concentrates by flow cytometry
  15. Circadian variation of holo-transcobalamin (holo-TC) and related markers
  16. Elevated levels of plasma homocysteine in postmenopausal women in Burkina Faso
  17. Allergy testing on the IMMULITE 2000 Random-Access immunoanalyzer – a clinical evaluation study
  18. Evaluation of the ABX Pentra 400: a newly available clinical chemistry analyser
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