Inter-individual variation of inflammatory markers of cardiovascular risks and diseases
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Hind Berrahmoune
Abstract
Cardiovascular diseases are a real public health problem and have multifactorial origin. Full comprehension of these diseases is very difficult because of their clinical and biological heterogeneity. The best way to understand the development of these diseases is to first investigate each biological system involved in the diseases and secondly, interactions between them. Studying intermediate phenotype variation for these biological systems is a new and promising approach for their elucidation. Among these metabolic systems, inflammation is known to be implicated in the occurrence and worsening of cardiovascular diseases. For this review, we chose to report the most important results concerning environmental, genetic and epigenetic determinants that influence intermediate phenotypes (protein and RNA levels) of inflammation. Indeed, numerous studies have investigated these determinants in healthy populations, in other words, without the influence of either disease or medication. This new approach will help to better understand the regulation of these intermediate phenotypes and to identify a panel of risk markers, which may be useful in predicting and warning those at risk and in giving adequate treatment to each patient.
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Articles in the same Issue
- Inter-individual variation of inflammatory markers of cardiovascular risks and diseases
- “Coelionomics”: towards understanding the molecular pathology of coeliac disease
- Gene expression profiling in human cardiovascular disease
- A common CYP1B1 polymorphism is associated with 2-OHE1/16-OHE1 urinary estrone ratio
- A quantitative RT-PCR method to determine topoisomerase I mRNA levels in human tissue samples
- Insulin sensitivity and counter-regulatory hormones in hypothyroidism and during thyroid hormone replacement therapy
- Linearity and detection limit in the measurement of serum M-protein with the capillary zone electrophoresis system Capillarys ®
- Quantitative measurement of ketone bodies in urine using reflectometry
- Quantification of voriconazole in plasma by liquid chromatography-tandem mass spectrometry
- Determination of the antioxidant capacity in blood
- High-workload endurance training may increase serum ischemia-modified albumin concentrations
- Advanced oxidation protein products in serum of patients with myotonic disease type I: association with serum γ-glutamyltransferase and disease severity
- Effectiveness of different methods for anti-Sm antibody identification. A multicentre study
- Quality control in neutrophil granulocyte (PMN) concentrates by flow cytometry
- Circadian variation of holo-transcobalamin (holo-TC) and related markers
- Elevated levels of plasma homocysteine in postmenopausal women in Burkina Faso
- Allergy testing on the IMMULITE 2000 Random-Access immunoanalyzer – a clinical evaluation study
- Evaluation of the ABX Pentra 400: a newly available clinical chemistry analyser
Articles in the same Issue
- Inter-individual variation of inflammatory markers of cardiovascular risks and diseases
- “Coelionomics”: towards understanding the molecular pathology of coeliac disease
- Gene expression profiling in human cardiovascular disease
- A common CYP1B1 polymorphism is associated with 2-OHE1/16-OHE1 urinary estrone ratio
- A quantitative RT-PCR method to determine topoisomerase I mRNA levels in human tissue samples
- Insulin sensitivity and counter-regulatory hormones in hypothyroidism and during thyroid hormone replacement therapy
- Linearity and detection limit in the measurement of serum M-protein with the capillary zone electrophoresis system Capillarys ®
- Quantitative measurement of ketone bodies in urine using reflectometry
- Quantification of voriconazole in plasma by liquid chromatography-tandem mass spectrometry
- Determination of the antioxidant capacity in blood
- High-workload endurance training may increase serum ischemia-modified albumin concentrations
- Advanced oxidation protein products in serum of patients with myotonic disease type I: association with serum γ-glutamyltransferase and disease severity
- Effectiveness of different methods for anti-Sm antibody identification. A multicentre study
- Quality control in neutrophil granulocyte (PMN) concentrates by flow cytometry
- Circadian variation of holo-transcobalamin (holo-TC) and related markers
- Elevated levels of plasma homocysteine in postmenopausal women in Burkina Faso
- Allergy testing on the IMMULITE 2000 Random-Access immunoanalyzer – a clinical evaluation study
- Evaluation of the ABX Pentra 400: a newly available clinical chemistry analyser