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Leucine aminopeptidases: diversity in structure and function

  • Mikiko Matsui , Jonathan H. Fowler und Linda L. Walling
Veröffentlicht/Copyright: 28. November 2006
Biological Chemistry
Aus der Zeitschrift Band 387 Heft 12

Abstract

Leucine aminopeptidases (LAPs) are metallopeptidases that cleave N-terminal residues from proteins and peptides. While hydrolyzing Leu substrates, LAPs often have a broader specificity. LAPs are members of the M1 or M17 peptidase families, and therefore the LAP nomenclature is complex. LAPs are often viewed as cell maintenance enzymes with critical roles in turnover of peptides. In mammals, the M17 and M1 enzymes with LAP activity contribute to processing peptides for MHC I antigen presentation, processing of bioactive peptides (oxytocin, vasopressin, enkephalins), and vesicle trafficking to the plasma membrane. In microbes, the M17 LAPs have a role in proteolysis and have also acquired the ability to bind DNA. This property enables LAPs to serve as transcriptional repressors to control pyrimidine, alginate and cholera toxin biosynthesis, as well as mediate site-specific recombination events in plasmids and phages. In plants the roles of the M17 LAPs and the peptidases related to M1 LAPs are being elucidated. Roles in defense, membrane transport of auxin receptors, and meiosis have been implicated.

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Published Online: 2006-11-28
Published in Print: 2006-12-01

©2006 by Walter de Gruyter Berlin New York

Artikel in diesem Heft

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  2. Leucine aminopeptidases: diversity in structure and function
  3. Endogenous anti-inflammatory substances, inter-α-inhibitor and bikunin
  4. Mitochondrial morphology and distribution in mammalian cells
  5. Heterogeneity in the cysteine protease inhibitor clitocypin gene family
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  7. Evaluation of Bacillus anthracis thymidine kinase as a potential target for the development of antibacterial nucleoside analogs
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  11. The role of human tissue kallikreins 7 and 8 in intracranial malignancies
  12. Prognostic significance of the expression of SR-A1, encoding a novel SR-related CTD-associated factor, in breast cancer
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  14. Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells
  15. Two secreted cystatins of the soft tick Ornithodoros moubata: differential expression pattern and inhibitory specificity
  16. Acknowledgment
  17. Contents Biological Chemistry Volume 387, 2006
  18. Author Index
  19. Subject Index
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