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Prognostic significance of the expression of SR-A1, encoding a novel SR-related CTD-associated factor, in breast cancer

  • Theoni Leoutsakou , Maroulio Talieri and Andreas Scorilas
Published/Copyright: November 28, 2006
Biological Chemistry
From the journal Volume 387 Issue 12

Abstract

SR-A1 is a human high-molecular-weight SR-related CTD-associated factor that links the machineries of transcription and mRNA splicing. In this study we examined the prognostic value of SR-A1 gene expression using a semi-quantitative RT-PCR method. High SR-A1 expression was observed in 31/81 (38.3%) breast cancer tissues and was found to be more frequent in patients with tumors of large size (p=0.027), as well as in lymph node-positive patients (p=0.035). Follow-up analysis revealed that low SR-A1 expression increases the probability of both overall and disease-free survival of patients. Our results suggest that SR-A1 may possibly be characterized as a new marker of unfavorable prognosis for breast cancer.

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Published Online: 2006-11-28
Published in Print: 2006-12-01

©2006 by Walter de Gruyter Berlin New York

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  16. Acknowledgment
  17. Contents Biological Chemistry Volume 387, 2006
  18. Author Index
  19. Subject Index
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