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The Role of the Proteasome System and the Proteasome Activator PA28 Complex in the Cellular Immune Response

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Published/Copyright: June 1, 2005
Biological Chemistry
From the journal Volume 380 Issue 3

Abstract

The generation of antigenic peptides bound and presented to the immune system by MHC class I molecules predominantly depends on the function of the proteasome system. Stimulation of cells with interferon gamma induces the incorporation of three active site bearing β-subunits into the 20S proteasome and the formation of the PA28 proteasome modulator complex. PA28 alters the cleavage properties of the proteasome and enhances MHC class I antigen presentation. Thus, by cytokine induced change of the proteasome system cells may alter the proteolytic properties of the 20S proteasome and may render an organism more flexible in its peptide generation capacity.

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Published Online: 2005-06-01
Published in Print: 1999-03-01

Copyright © 1999 by Walter de Gruyter GmbH & Co. KG

Articles in the same Issue

  1. Chimeric Virus-Like Particles as Vaccines
  2. The Core Antigen of Hepatitis B Virus as a Carrier for Immunogenic Peptides
  3. Enhancing the Immunogenicity of Exogenous Hepatitis B Surface Antigen-Based Vaccines for MHC-I-Restricted T Cells
  4. The Role of the Proteasome System and the Proteasome Activator PA28 Complex in the Cellular Immune Response
  5. Ty Virus-Like Particles, DNA Vaccines and Modified Vaccinia Virus Ankara; Comparisons and Combinations
  6. Chaperones Involved in Hepatitis B Virus Morphogenesis
  7. Behavior of a Short preS1 Epitope on the Surface of Hepatitis B Core Particles
  8. HBV Core Particles Allow the Insertion and Surface Exposure of the Entire Potentially Protective Region of Puumala Hantavirus Nucleocapsid Protein
  9. Induction of HPV16 Capsid Protein-Specific Human T Cell Responses by Virus-Like Particles
  10. Construction and Characterization of Recombinant VLPs and Semliki-Forest Virus Live Vectors for Comparative Evaluation in the SHIV Monkey Model
  11. Development of HIV/AIDS Vaccine Using Chimeric gag-env Virus-Like Particles
  12. A Disulfide-Bound HIV-1 V3 Loop Sequence on the Surface of Human Rhinovirus 14 Induces Neutralizing Responses against HIV-1
  13. DNA-Plasmids of HIV-1 Induce Systemic and Mucosal Immune Responses
  14. Yeast Cells Allow High-Level Expression and Formation of Polyomavirus-Like Particles
  15. Position-Dependent Processing of Peptides Presented on the Surface of Cowpea Mosaic Virus
  16. Protection of Baculovirus-Vectors against Complement-Mediated Inactivation by Recombinant Soluble Complement Receptor Type 1
  17. Site-Specific Fluorescence Labelling of Recombinant Polyomavirus-Like Particles
https://doi.org/10.1515/BC.1999.040

Articles in the same Issue

  1. Chimeric Virus-Like Particles as Vaccines
  2. The Core Antigen of Hepatitis B Virus as a Carrier for Immunogenic Peptides
  3. Enhancing the Immunogenicity of Exogenous Hepatitis B Surface Antigen-Based Vaccines for MHC-I-Restricted T Cells
  4. The Role of the Proteasome System and the Proteasome Activator PA28 Complex in the Cellular Immune Response
  5. Ty Virus-Like Particles, DNA Vaccines and Modified Vaccinia Virus Ankara; Comparisons and Combinations
  6. Chaperones Involved in Hepatitis B Virus Morphogenesis
  7. Behavior of a Short preS1 Epitope on the Surface of Hepatitis B Core Particles
  8. HBV Core Particles Allow the Insertion and Surface Exposure of the Entire Potentially Protective Region of Puumala Hantavirus Nucleocapsid Protein
  9. Induction of HPV16 Capsid Protein-Specific Human T Cell Responses by Virus-Like Particles
  10. Construction and Characterization of Recombinant VLPs and Semliki-Forest Virus Live Vectors for Comparative Evaluation in the SHIV Monkey Model
  11. Development of HIV/AIDS Vaccine Using Chimeric gag-env Virus-Like Particles
  12. A Disulfide-Bound HIV-1 V3 Loop Sequence on the Surface of Human Rhinovirus 14 Induces Neutralizing Responses against HIV-1
  13. DNA-Plasmids of HIV-1 Induce Systemic and Mucosal Immune Responses
  14. Yeast Cells Allow High-Level Expression and Formation of Polyomavirus-Like Particles
  15. Position-Dependent Processing of Peptides Presented on the Surface of Cowpea Mosaic Virus
  16. Protection of Baculovirus-Vectors against Complement-Mediated Inactivation by Recombinant Soluble Complement Receptor Type 1
  17. Site-Specific Fluorescence Labelling of Recombinant Polyomavirus-Like Particles
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