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New perspectives and strategy research biomarkers for hepatocellular carcinoma

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Veröffentlicht/Copyright: 11. September 2007
Clinical Chemistry and Laboratory Medicine (CCLM)
Aus der Zeitschrift Band 45 Heft 9

Abstract

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Cirrhosis caused by hepatitis B virus, hepatitis C virus or chronic alcohol intake is associated with major risk. Systematic screening for HCC of asymptomatic patients with cirrhosis is needed for earlier detection of small tumors requiring treatment (liver transplantation, surgical resection, percutaneous techniques). The recommended screening strategy among cirrhotic patients is based on regular liver ultrasonography associated with serum α-fetoprotein (AFP) assay. As the performance of AFP is not satisfactory, additional tumoral markers are proposed (des-γ-carboxyprothrombin, glycosylated AFP-L3 fraction). Currently, diagnosis of HCC in cirrhotic patients includes non-invasive tests (imaging after contrast administration, AFP assay); diagnostic biopsy is performed when imaging is limited. After treatment, tumor recurrence is assessed by regular follow-up (AFP assay and imaging). Despite the lack of accurate markers, recent developments in genomic and proteomic approaches will allow the discovery of new biomarkers for primary tumors, as well as for recurrence. This review summarizes the current state of biomarkers for screening, diagnosis and follow-up of HCC, and highlights new perspectives in the field.

Clin Chem Lab Med 2007;45:1169–79.

Keywords: biological markers; cirrhosis; α-fetoprotein; genomic; hepatocellular carcinoma
Corresponding author: Dr. Raphael Saffroy, Service de Biochimie, Biologie Moléculaire et Toxicologie, Hôpital Universitaire Paul Brousse, 14, avenue Paul Vaillant Couturier, 94804 Villejuif cedex, France Phone: +33-1-45596903,
Received: 2007-2-18
Accepted: 2007-5-21
Published Online: 2007-09-11
Published in Print: 2007-09-01

©2007 by Walter de Gruyter Berlin New York

Artikel in diesem Heft

  1. SIBioC 2007, 39th National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology, Palacongressi Rimini (Italy), 2-5 October 2007
  2. Third “Biologie Prospective” Santorini Conference
  3. Application of leukocyte transcriptomes to assess systemic consequences of risk factors for cardiovascular disease
  4. Ghrelin variants influence development of body mass index and plasma levels of total cholesterol in dialyzed patients
  5. Evaluation of genetic predisposition to insulin resistance by nutrient-induced insulin output ratio (NIOR)
  6. Apolipoprotein A-V gene polymorphisms in subjects with metabolic syndrome
  7. Prothrombogenic factors and reduced antioxidative defense in children and adolescents with pre-metabolic and metabolic syndrome
  8. Interleukin-6 gene promoter –174G/C polymorphism and insulin resistance: a pilot study
  9. Apolipoprotein E polymorphism – a risk factor for metabolic syndrome
  10. Peripheral blood mononuclear cells (PBMCs): a possible model for studying cardiovascular biology systems
  11. New perspectives and strategy research biomarkers for hepatocellular carcinoma
  12. Reproducibility of impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) classification: a systematic review
  13. The uncoupling protein-1 gene −3826A/G polymorphism and hypertension in Japanese subjects
  14. Association between the TaqIB polymorphism in the cholesteryl ester transfer protein gene locus and postprandial plasma lipoprotein levels in heterozygotes for familial hypercholesterolemia
  15. Histamine induces the expression of uncoupling protein 2 (UCP2) and acid-binding protein (aP2) in white adipocytes
  16. Biochemical and clinical correlates of hypouricemia in surgical and critically ill patients
  17. Reliability of oxidative stress biomarkers in hemodialysis patients: a comparative study
  18. The association between lipid profiles and breast cancer among Taiwanese women
  19. Inverse association between serum selenium concentrations and parameters of immune activation in patients with cardiac disorders
  20. Associations of blood levels of insulin-like growth factor (IGF)-I, IGF-II and IGF binding protein (IGFBP)-3 in schizophrenic Arab subjects
  21. Sources of variation and reference intervals for serum cystatin C in a healthy Japanese adult population
  22. Intra-individual variation in creatinine and cystatin C
  23. Gammopathy interference in clinical chemistry assays: mechanisms, detection and prevention
  24. An Italian program of External Quality Control for chromogranin A (CgA) assay: performance evaluation of CgA determination
  25. Automated urinalysis: first experiences and a comparison between the Iris iQ200 urine microscopy system, the Sysmex UF-100 flow cytometer and manual microscopic particle counting
  26. Type B natriuretic peptide stability in frozen plasma
https://doi.org/10.1515/CCLM.2007.262
Schlagwörter für diesen Artikel
biological markers; cirrhosis; α-fetoprotein; genomic; hepatocellular carcinoma

Artikel in diesem Heft

  1. SIBioC 2007, 39th National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology, Palacongressi Rimini (Italy), 2-5 October 2007
  2. Third “Biologie Prospective” Santorini Conference
  3. Application of leukocyte transcriptomes to assess systemic consequences of risk factors for cardiovascular disease
  4. Ghrelin variants influence development of body mass index and plasma levels of total cholesterol in dialyzed patients
  5. Evaluation of genetic predisposition to insulin resistance by nutrient-induced insulin output ratio (NIOR)
  6. Apolipoprotein A-V gene polymorphisms in subjects with metabolic syndrome
  7. Prothrombogenic factors and reduced antioxidative defense in children and adolescents with pre-metabolic and metabolic syndrome
  8. Interleukin-6 gene promoter –174G/C polymorphism and insulin resistance: a pilot study
  9. Apolipoprotein E polymorphism – a risk factor for metabolic syndrome
  10. Peripheral blood mononuclear cells (PBMCs): a possible model for studying cardiovascular biology systems
  11. New perspectives and strategy research biomarkers for hepatocellular carcinoma
  12. Reproducibility of impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) classification: a systematic review
  13. The uncoupling protein-1 gene −3826A/G polymorphism and hypertension in Japanese subjects
  14. Association between the TaqIB polymorphism in the cholesteryl ester transfer protein gene locus and postprandial plasma lipoprotein levels in heterozygotes for familial hypercholesterolemia
  15. Histamine induces the expression of uncoupling protein 2 (UCP2) and acid-binding protein (aP2) in white adipocytes
  16. Biochemical and clinical correlates of hypouricemia in surgical and critically ill patients
  17. Reliability of oxidative stress biomarkers in hemodialysis patients: a comparative study
  18. The association between lipid profiles and breast cancer among Taiwanese women
  19. Inverse association between serum selenium concentrations and parameters of immune activation in patients with cardiac disorders
  20. Associations of blood levels of insulin-like growth factor (IGF)-I, IGF-II and IGF binding protein (IGFBP)-3 in schizophrenic Arab subjects
  21. Sources of variation and reference intervals for serum cystatin C in a healthy Japanese adult population
  22. Intra-individual variation in creatinine and cystatin C
  23. Gammopathy interference in clinical chemistry assays: mechanisms, detection and prevention
  24. An Italian program of External Quality Control for chromogranin A (CgA) assay: performance evaluation of CgA determination
  25. Automated urinalysis: first experiences and a comparison between the Iris iQ200 urine microscopy system, the Sysmex UF-100 flow cytometer and manual microscopic particle counting
  26. Type B natriuretic peptide stability in frozen plasma
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