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Conceptual design and cost-efficient environmentally Benign synthesis of beta-lactams

  • Aparna Das ORCID logo , Ram Naresh Yadav and Bimal Krishna Banik EMAIL logo
Published/Copyright: May 4, 2022
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Physical Sciences Reviews
From the journal Physical Sciences Reviews Volume 8 Issue 11

Abstract

Stereoselective preparation of diverse trans and cis β-lactams following different experimental conditions are executed. A variety of circumstances are critically analyzed. It has been found that the stereochemistry of the products depends on a number of parameters including the conditions of the procedures, composition of the Schiff bases and acid chlorides or equivalents, method of addition of the reactants, temperature of the process and nature of the media. Using some of the compounds and methods as described herein, a number of useful chemical transformations for the preparation of heterocycles are achieved. These methods include indium-catalyzed glycosylation of amino β-lactams, preparation of pyrrole-substituted β-lactams, cycloaddition with sterically congested Schiff bases towards β-lactams, Michael reaction for the preparation of polycyclic oxazepenes and synthesis of two chiral isomers of the thienamycin side chain. Most of the products are obtained stereospecifically and in optically active forms. Many reactions described here are catalytic and therefore, these are environmentally friendly.

Keywords: β-lactams; catalyst; design; organic molecules; stereochemistry; synthesis
Corresponding author: Bimal Krishna Banik, Department of Mathematics and Natural Sciences-Core Curriculum, Prince Mohammad Bin Fahd University, Al Khobar, 31952, Kingdom of Saudi Arabia, E-mail:

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2022-02-07
Accepted: 2022-04-09
Published Online: 2022-05-04

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/psr-2021-0088
Keywords for this article
β-lactams; catalyst; design; organic molecules; stereochemistry; synthesis

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