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Ethnopharmacology, phytochemistry and a new chemotaxonomic marker in Oldenlandia affinis (Roem. & Schult.) DC. Rubiaceae

  • Francis Alfred Attah EMAIL logo , Augustine E. Mbanu , Uche M. Chukwudulue , Ugochukwu J. Jonah and Ngaitad S. Njinga
Published/Copyright: April 28, 2022
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Physical Sciences Reviews
From the journal Physical Sciences Reviews Volume 8 Issue 11

Abstract

The proper documentation of ethnopharmacological application of widely used indigenous plants and their phytochemical analysis has positively impacted the drug discovery pipeline. Medicinal plants with potential commercial value and prospects for clinical application need to be properly identified and authenticated to avoid confusion, adulteration and substitution. Oldenlandia affinis (OA) has continued to attract scientific attention following the discovery of extremely stable cyclotides (circular peptides) that are not expressed in many investigated members of the contentious genus, Oldenlandia (synonym – Hedyotis); yet there is a lack of an elaborate review covering some broader aspects of its traditional uses, ethnopharmacology and phytochemistry of the species. More importantly, the age long but lingering confusion and taxonomic inconsistencies common to the Oldenlandia–Hedyotis debate could foster species mismatching, increase cases of misidentification, promote adulteration of OA and thereby limit its proper clinical application. Here, we aim to reveal the extent of indigenous use of and research on OA from 1960 till date, unveil knowledge gaps, document hitherto unknown traditional applications, ethnopharmacological uses, pharmacological properties, and reported phytochemical profile. In addition, to encourage proper selection and utilization of genuine crude drug, the chemotaxonomically important phytoconstituents of OA have been presented and the modern approach of chemophenetic study of OA proposed to resolve the lack of consensus in the taxonomy of OA as well as the morphologically and anatomically close members of the taxon. The abundant cyclotide expression in OA represents a new chemotaxonomic marker for its unambiguous identification, utilization and reproducibility of research findings on the species.

Keywords: chemotaxonomy; cyclotides; ethnopharmacology; Oldenlandia affinis ; phytochemistry
Corresponding author: Francis Alfred Attah, Department of Pharmacognosy and Drug Development, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria, E-mail:

  1. Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Published Online: 2022-04-28

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/psr-2021-0196
Keywords for this article
chemotaxonomy; cyclotides; ethnopharmacology; Oldenlandia affinis; phytochemistry

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Anticancer properties of arylchromenes and arylchromans: an overview
  4. Solid state lithium ion conductors for lithium batteries
  5. Performance and kinetics of a fluidized bed anaerobic reactor treating distillery effluent
  6. Use of biochemical markers for diabetes prevention in the new decade
  7. Antibreast cancer activities of phytochemicals from Anonna muricata using computer-aided drug design (CADD) approach
  8. Alkaline-earth metal(II) complexes of salinomycin – spectral properties and antibacterial activity
  9. Use of heterogeneous catalysis in sustainable biofuel production
  10. Antibacterial, antioxidant and cytotoxic activities of the stem bark of Archidendron jiringa (Jack) I.C. Nielsen
  11. A review of sludge production in South Africa municipal wastewater treatment plants, analysis of handling cost and potential minimization methods
  12. Cu-Catalysed tandem reactions for building poly hetero atom heterocycles-green chemistry tool
  13. Optimizing Cr(VI) adsorption parameters on magnetite (Fe3O4) and manganese doped magnetite (MnxFe(3-x)O4) nanoparticles
  14. Fabaceae: a significant flavonoid source for plant and human health
  15. A novel application of synthesised based squarylium dyes on nylon 6, and silk woven fabrics
  16. Chromatographic characterization of the fusion protein SARS-CoV-2 S protein (RBD)-hFc
  17. Ethnopharmacology, phytochemistry and a new chemotaxonomic marker in Oldenlandia affinis (Roem. & Schult.) DC. Rubiaceae
  18. Extraction, isolation and characterization of secondary metabolites in the leaves of Morinda lucida from Oshiegbe in Ebonyi State
  19. Lead optimisation efforts on a molecular prototype of the immunomodulatory parasitic protein ES-62
  20. Catalytic applications of graphene oxide towards the synthesis of bioactive scaffolds through the formation of carbon–carbon and carbon–heteroatom bonds
  21. Synthesis, characterization, DFT and molecular docking studies of acetone O-((2,5-dichlorophenyl)sulfonyl) oxime
  22. Design of membrane systems
  23. Conceptual design and cost-efficient environmentally Benign synthesis of beta-lactams
  24. Synthesis and characterization of alkaloid derived hydrazones and their metal (II) complexes
  25. The spontaneity of chemical reactions: challenges with handling the concept and its implications
  26. Copper nanoparticles catalyzed carbon–heteroatom bond formation and synthesis of related heterocycles by greener procedures
  27. Tellurium in carbohydrate synthesis
  28. Conformational preferences and intramolecular hydrogen bonding patterns of tetraflavaspidic acid BBBB – a tetrameric acylphloroglucinol
  29. Phytochemical and antioxidant studies of Hibiscus Cannabinus seed oil
  30. Polyaniline mediated heterogeneous catalysis in the preparation of heterocyclic derivatives through carbon–heteroatom bond formations
  31. A comparison of two digestion methods and heavy metals determination in sediments
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  33. Recyclable magnetically retrievable nanocatalysts for C–heteroatom bond formation reactions
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