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Use of biochemical markers for diabetes prevention in the new decade

  • Marie Chan Sun ORCID logo , Marie A. S. Landinaff EMAIL logo and Ruben Thoplan
Published/Copyright: April 6, 2022
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Physical Sciences Reviews
From the journal Physical Sciences Reviews Volume 8 Issue 11

Abstract

Use of biochemical markers for diabetes prevention in the new decade. There is established evidence that type 2 diabetes mellitus is preceded by a phase, during which there is a cluster of conditions including raised triglycerides and lowered high-density lipoprotein cholesterol, raised fasting glucose, high blood pressure and central obesity. This cluster of risk factors for type 2 diabetes mellitus, constitutes the metabolic syndrome (MetS). Therefore, there is need to screen for this syndrome among the population for the primary prevention of type 2 diabetes mellitus which is a global public health problem. Despite the high prevalence of type 2 diabetes in Mauritius, research work on MetS is scarce. This study was thus undertaken with the primary objective to determine the prevalence of MetS among the employees of a public educational institution in Mauritius. A cross-sectional study which involved randomly identified employees was conducted. The participants were requested to fill in a survey questionnaire, undergo biometric measurements (waist circumference and blood pressure) and venous blood sample collection in a fasting condition. The blood tests included the determination of glucose, triglyceride and cholesterol levels. The 2009 International Diabetes Federation criteria were used for the diagnosis of MetS. The presence of any 3 of 5 risk factors, raised triglycerides, raised glucose, lowered high-density lipoprotein cholesterol, high blood pressure and central obesity constitutes a diagnosis of metabolic syndrome. Ethical clearance was obtained from the Department of Medicine Research Ethics Committee of the University of Mauritius. The prevalence of MetS was found to be 20.1% (40 participants), in the overall population, 31.4% in men (22 out of 70) and 13.95% in women (18 out of 129). The determination of any association by means of the Chi square tests showed there was a significant association between gender and MetS (p < 0.01). Educational level was also associated with the MetS (p < 0.05). Logistic regression analysis confirmed t\he significant association between MetS with gender (p < 0.01) where male gender was more associated with MetS than female. This study with the determination of the prevalence of the MetS among employees constituted the first step in the implementation of a structured workplace health intervention programme in Mauritius. We highlight the importance of workplace interventions with the involvement of a multi-disciplinary team of health professionals for the primary prevention of diabetes, through the screening for the MetS among employees.

Keywords: biochemical markers; diabetes mellitus; Mauritius; metabolic syndrome; prevalence
Corresponding author: Marie A. S. Landinaff, Department of Medicine, University of Mauritius, Reduit, Mauritius, E-mail:

Acknowledgements

The authors are grateful to all the participants for their involvement and to the laboratory/nursing team for their support during the data collection phase of the study.

  1. Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

References

1. International Diabetes Federation. Consensus worldwide definition of the metabolic syndrome. Belgium: International Diabetes Federation; 2009.Search in Google Scholar

2. Sorrentino, MJ. Implications of the metabolic syndrome: the new epidemic. Am J Cardiol 2005;96:3–7, https://doi.org/10.1016/j.amjcard.2005.05.008.Search in Google Scholar PubMed

3. Saklayen, MG. The global epidemic of the metabolic syndrome. Curr Hypertens Rep 2018;20:1–8, https://doi.org/10.1007/s11906-018-0812-z.Search in Google Scholar PubMed PubMed Central

4. De la Iglesia, R, Loria-Kohen, V, Zulet, MA, Martinez, JA, Reglero, G, Ramirez de Molina, A. Dietary strategies implicated in the prevention and treatment of metabolic syndrome. Int J Mol Sci 2016;17:1877, https://doi.org/10.3390/ijms17111877.Search in Google Scholar PubMed PubMed Central

5. Zimmet, P. Globalization, coca‐colonization and the chronic disease epidemic: can the Doomsday scenario be averted? J Intern Med 2001;249:17–26, https://doi.org/10.1046/j.1365-2796.2001.00625.x.Search in Google Scholar

6. World Health Organization. Noncommunicable diseases country profiles. Geneva: World Health Organization; 2018.Search in Google Scholar

7. Ministry of Health and Quality of Life. Mauritius Non-Communicable Diseases Survey. Port Louis: Government of Mauritius; 2015.Search in Google Scholar

8. Chan Sun, M, Abdool Raheem, J, Ramasawmy, D. What Future for Employees with Metabolic Syndrome? The International Conference on Pure and Applied Chemistry. Theme Chemistry: The Key for our Future. Mauritius; 2012.Search in Google Scholar

9. Kutlu, B, Çeken, B, Mutlutürk, M, Türkmen, C. A Meta-Analysis of Social Media & Learning Studies in Educational Research. 5th International Management Information Systems Conference. IMISC: Ankara; 2018.Search in Google Scholar

10. Yeh, WC, Chuang, HH, Lu, MC, Tzeng, IS, Chen, JY. Prevalence of metabolic syndrome among employees of a taiwanese hospital varies according to profession. Medicine 2018;97:e11664, https://doi.org/10.1097/MD.0000000000011664.Search in Google Scholar PubMed PubMed Central

11. Cattafesta, M, Bissoli, NS, Salaroli, LB. Metabolic syndrome and C-reactive protein in bank employees. Diabetes, Metab Syndrome Obes Targets Ther 2016;9:137, https://doi.org/10.2147/DMSO.S101283.Search in Google Scholar PubMed PubMed Central

12. Roomi, MA, Mohammadnezhad, M. Prevalence of metabolic syndrome among apparently healthy workforce. J Ayub Med Coll Abbottabad 2019;31:252–64.Search in Google Scholar

13. Al-Rubeaan, K, Bawazeer, N, Al Farsi, Y, Youssef, AM, Al-Yahya, AA, AlQumaidi, H, et al.. Prevalence of metabolic syndrome in Saudi Arabia-a cross sectional study. BMC Endocr Disord 2018;18:1–9, https://doi.org/10.1186/s12902-018-0244-4.Search in Google Scholar PubMed PubMed Central

14. Li, Y, Zhao, L, Yu, D, Wang, Z, Ding, G. Metabolic syndrome prevalence and its risk factors among adults in China: a nationally representative cross-sectional study. PLoS One 2018;13:e0199293, https://doi.org/10.1371/journal.pone.0199293.Search in Google Scholar PubMed PubMed Central

15. Sigit, FS, Tahapary, DL, Trompet, S, Sartono, E, Van Dijk, KW, Rosendaal, FR, et al.. The prevalence of metabolic syndrome and its association with body fat distribution in middle-aged individuals from Indonesia and The Netherlands: a cross-sectional analysis of two population-based studies. Diabetol Metab Syndrome 2020;12:1, https://doi.org/10.1186/s13098-019-0503-1.Search in Google Scholar PubMed PubMed Central

16. Van Der Linden, EL, Meeks, K, Beune, E, de-Graft Aikins, A, Addo, J, Owusu-Dabo, E, et al.. The prevalence of metabolic syndrome among Ghanaian migrants and their homeland counterparts: the research on obesity and type 2 diabetes among African Migrants (RODAM) study. Eur J Publ Health 2019;29:906–13, https://doi.org/10.1093/eurpub/ckz051.Search in Google Scholar PubMed PubMed Central

17. Kim, I, Song, YM, Ko, H, Sung, J, Lee, K, Shin, J, et al.. Educational disparities in risk for metabolic syndrome. Metab Syndr Relat Disord 2018;16:416–24, https://doi.org/10.1089/met.2017.0170.Search in Google Scholar PubMed

18. Burton, WN, Chen, CY, Schultz, AB, Edington, DW. The prevalence of metabolic syndrome in an employed population and the impact on health and productivity. J Occup Environ Med 2008;50:1139–48, https://doi.org/10.1097/jom.0b013e318188b8eb.Search in Google Scholar PubMed

19. Hu, X, Yu, W, Yang, L, Pan, W, ya Si, Q, Chen, X, et al.. The association between first-degree family history of diabetes and metabolic syndrome. Endocr Pract 2019;25:678–83, https://doi.org/10.4158/ep-2018-0543.Search in Google Scholar

20. Eckel, RH, Grundy, SM, Zimmet, PZ. The metabolic syndrome. Lancet 2005;365:1415–28, https://doi.org/10.1016/s0140-6736(05)66378-7.Search in Google Scholar PubMed

21. He, D, Xi, B, Xue, J, Huai, P, Zhang, M, Li, J. Association between leisure time physical activity and metabolic syndrome: a meta-analysis of prospective cohort studies. Endocrine 2014;46:231–40, https://doi.org/10.1007/s12020-013-0110-0.Search in Google Scholar PubMed

22. Paley, CA, Johnson, MI. Abdominal obesity and metabolic syndrome: exercise as medicine? BMC Sports Sci Med Rehabil 2018;10:1–8, https://doi.org/10.1186/s13102-018-0097-1.Search in Google Scholar PubMed PubMed Central

23. Cheng, E, Burrows, R, Correa, P, Güichapani, CG, Blanco, E, Gahagan, S. Light smoking is associated with metabolic syndrome risk factors in Chilean young adults. Acta Diabetol 2019;56:473–9, https://doi.org/10.1007/s00592-018-1264-2.Search in Google Scholar PubMed PubMed Central

24. Vieira, BA, Luft, VC, Schmidt, MI, Chambless, LE, Chor, D, Barreto, SM, et al.. Timing and type of alcohol consumption and the metabolic syndrome-ELSA-Brasil. PLoS One 2016;11:e0163044, https://doi.org/10.1371/journal.pone.0163044.Search in Google Scholar PubMed PubMed Central

25. Chartier, K, Caetano, R. Ethnicity and health disparities in alcohol research. Alcohol Res Health 2010;33:152.Search in Google Scholar

26. Choi, S, Kim, K, Lee, JK, Choi, JY, Shin, A, Park, SK, et al.. Association between change in alcohol consumption and metabolic syndrome: analysis from the health examinees study. Diabetes Metabol J 2019;43:615–26, https://doi.org/10.4093/dmj.2018.0128.Search in Google Scholar PubMed PubMed Central

27. Rizzo, NS, Sabaté, J, Jaceldo-Siegl, K, Fraser, GE. Vegetarian dietary patterns are associated with a lower risk of metabolic syndrome: the adventist health study 2. Diabetes Care 2011;34:1225–7, https://doi.org/10.2337/dc10-1221.Search in Google Scholar PubMed PubMed Central

28. Sabaté, J, Wien, M. A perspective on vegetarian dietary patterns and risk of metabolic syndrome. Br J Nutr 2015;113:S136–43.10.1017/S0007114514004139Search in Google Scholar PubMed

29. Luan, D, Wang, D, Campos, H, Baylin, A. Red meat consumption and metabolic syndrome in the Costa Rica Heart Study. Eur J Nutr 2020;59:185–93, https://doi.org/10.1007/s00394-019-01898-6.Search in Google Scholar PubMed

30. Beebeejaun-Roojee, S, Mohun, S, Ruggoo, A. An Assessment of the Nutritional Knowledge and Eating Habits of Vegetarians in Mauritius. Univ Mauritius Res J 2014;20:122–37.Search in Google Scholar

31. Subratty, AH, Beeharry, P, Sun, MC. A survey of hygiene practices among food vendors in rural areas in Mauritius. Nutr Food Sci 2004, https://doi.org/10.1108/00346650410560361.Search in Google Scholar

32. Murray, CJ, Aravkin, AY, Zheng, P, Abbafati, C, Abbas, KM, Abbasi-Kangevari, M, et al.. Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 2020;396:1223–49, https://doi.org/10.1016/S0140-6736(20)30752-2.Search in Google Scholar PubMed PubMed Central

33. Islam, SM, Purnat, TD, Phuong, NT, Mwingira, U, Schacht, K, Fröschl, G. Non‐communicable diseases (NCDs) in developing countries: a symposium report. Glob Health 2014;10:1–8, https://doi.org/10.1186/s12992-014-0081-9.Search in Google Scholar PubMed PubMed Central

34. Jiménez‐Mérida, MR, Romero‐Saldaña, M, Molina‐Luque, R, Molina‐Recio, G, Meneses‐Monroy, A, De Diego‐Cordero, R, et al.. Women‐centred workplace health promotion interventions: a systematic review. Int Nurs Rev 2021;68:90–8.10.1111/inr.12637Search in Google Scholar PubMed

Published Online: 2022-04-06

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/psr-2021-0166
Keywords for this article
biochemical markers; diabetes mellitus; Mauritius; metabolic syndrome; prevalence

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Anticancer properties of arylchromenes and arylchromans: an overview
  4. Solid state lithium ion conductors for lithium batteries
  5. Performance and kinetics of a fluidized bed anaerobic reactor treating distillery effluent
  6. Use of biochemical markers for diabetes prevention in the new decade
  7. Antibreast cancer activities of phytochemicals from Anonna muricata using computer-aided drug design (CADD) approach
  8. Alkaline-earth metal(II) complexes of salinomycin – spectral properties and antibacterial activity
  9. Use of heterogeneous catalysis in sustainable biofuel production
  10. Antibacterial, antioxidant and cytotoxic activities of the stem bark of Archidendron jiringa (Jack) I.C. Nielsen
  11. A review of sludge production in South Africa municipal wastewater treatment plants, analysis of handling cost and potential minimization methods
  12. Cu-Catalysed tandem reactions for building poly hetero atom heterocycles-green chemistry tool
  13. Optimizing Cr(VI) adsorption parameters on magnetite (Fe3O4) and manganese doped magnetite (MnxFe(3-x)O4) nanoparticles
  14. Fabaceae: a significant flavonoid source for plant and human health
  15. A novel application of synthesised based squarylium dyes on nylon 6, and silk woven fabrics
  16. Chromatographic characterization of the fusion protein SARS-CoV-2 S protein (RBD)-hFc
  17. Ethnopharmacology, phytochemistry and a new chemotaxonomic marker in Oldenlandia affinis (Roem. & Schult.) DC. Rubiaceae
  18. Extraction, isolation and characterization of secondary metabolites in the leaves of Morinda lucida from Oshiegbe in Ebonyi State
  19. Lead optimisation efforts on a molecular prototype of the immunomodulatory parasitic protein ES-62
  20. Catalytic applications of graphene oxide towards the synthesis of bioactive scaffolds through the formation of carbon–carbon and carbon–heteroatom bonds
  21. Synthesis, characterization, DFT and molecular docking studies of acetone O-((2,5-dichlorophenyl)sulfonyl) oxime
  22. Design of membrane systems
  23. Conceptual design and cost-efficient environmentally Benign synthesis of beta-lactams
  24. Synthesis and characterization of alkaloid derived hydrazones and their metal (II) complexes
  25. The spontaneity of chemical reactions: challenges with handling the concept and its implications
  26. Copper nanoparticles catalyzed carbon–heteroatom bond formation and synthesis of related heterocycles by greener procedures
  27. Tellurium in carbohydrate synthesis
  28. Conformational preferences and intramolecular hydrogen bonding patterns of tetraflavaspidic acid BBBB – a tetrameric acylphloroglucinol
  29. Phytochemical and antioxidant studies of Hibiscus Cannabinus seed oil
  30. Polyaniline mediated heterogeneous catalysis in the preparation of heterocyclic derivatives through carbon–heteroatom bond formations
  31. A comparison of two digestion methods and heavy metals determination in sediments
  32. Synthesis, properties and catalysis of quantum dots in C–C and C-heteroatom bond formations
  33. Recyclable magnetically retrievable nanocatalysts for C–heteroatom bond formation reactions
  34. Small molecules as next generation biofilm inhibitors and anti-infective agents
  35. Toxicity of tellurium and its compounds
  36. Biodegradable polycaprolactone (PCL) based polymer and composites
  37. Quality of poultry meat- the practical issues and knowledge based solutions
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