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Neonatal outcome of preterm discordant twins

  • Yaron Haimovich , Jessica Ascher-Landsberg , Fuad Azem , Dror Mandel , Francis B. Mimouni and Ariel Many EMAIL logo
Published/Copyright: April 14, 2011
Journal of Perinatal Medicine
From the journal Volume 39 Issue 3

Abstract

Objective: To estimate the influence of fetal growth restriction (FGR) on neonatal morbidity and mortality among premature discordant twin neonates.

Study design: Our medical records (2002–2007) of preterm twins born at 24–37 weeks’ gestation were reviewed. Significant discordance was defined as >15% difference in birth weight. Small for gestational age (SGA) was defined as birth weight <10th percentile, and appropriate for gestational age (AGA) was between the 10th and 90th percentile, according to a twin and sex-adjusted gestational age nomogram. The SGA/AGA group comprised of one SGA twin and its AGA pair (30 pairs). Another group of non-SGA discordant twins was also evaluated (n=40 pairs, AGA/AGA). The morbidity and mortality rates were compared between the groups.

Results: Of the selected outcome variables, the only ones in which the incidence was significantly lower for SGA neonates than their AGA pairs were respiratory distress syndrome (5 vs. 11, P=0.014), apnea (1 vs. 9, P=0.004) and the need for respiratory support (5 vs. 14, P=0.002). Anemia, erythropoietin therapy and hyperbilirubinemia were significantly higher in the SGA twin. All selected outcome variables had similar rates within the AGA/AGA pairs.

Conclusion: FGR among premature discordant twin pairs is associated with significantly lower rates of respiratory morbidity and higher anemia and erythropoietin therapy rates. Overall morbidity is similar for discordant non-FGR twin pairs.

Keywords: Appropriate for gestational age; fetal growth restriction; intrauterine growth restriction; small for gestational age; twins
Corresponding author: Ariel Many, MD MHA Lis Maternity Hospital Tel Aviv Sourasky Medical Center 6 Weizman Street Tel Aviv 64239 Israel Tel.: +972-3-6925603 Fax: +972-3-6925721
Received: 2010-8-2
Revised: 2010-10-21
Accepted: 2010-11-3
Published Online: 2011-04-14
Published Online: 2011-04-14
Published in Print: 2011-05-01

©2011 by Walter de Gruyter Berlin New York

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  1. Publisher’s Note
  2. Publisher’s Note
  3. EDITORIAL
  4. Problems in prevention of preterm birth – regrettable contradictions
  5. REVIEW ARTICLES
  6. Listeriosis in human pregnancy: a systematic review
  7. Prevention of prematurity by single embryo transfer
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  18. Prediction of successful labor induction by evaluation of maternal symptoms at an early stage of the misoprostol induction protocol
  19. ORIGINAL ARTICLES - FETUS
  20. Increased nuchal translucency is associated with large for gestational age neonates in singleton pregnancies
  21. ORIGINAL ARTICLES - NEWBORN
  22. Predicting mortality in infants with persistent pulmonary hypertension of the newborn with the Score for Neonatal Acute Physiology-Version II (SNAP-II) in Thai neonates
  23. Neonatal outcome of preterm discordant twins
  24. Effects of delayed umbilical cord clamping on peripheral blood hematopoietic stem cells in premature neonates
  25. In utero exposure to Ureaplasma spp. is associated with increased rate of bronchopulmonary dysplasia and intraventricular hemorrhage in preterm infants
  26. Does prenatal antibiotic therapy compromise the diagnosis of early-onset infection and management of the neonate?
  27. SNAPPE-II application in newborns with very low birth weight: evaluation of adverse outcomes in severe placental dysfunction
  28. SHORT COMMUNICATION
  29. Lamellar bodies: platelet channel particles as predictors of respiratory distress syndrome (RDS) and of transient tachypnea of the newborn
  30. Intrahepatic and adrenal hemorrhage as a rare cause of neonatal anemia
  31. Subcutaneous fat distribution in small for gestational age newborns
  32. Calendar
  33. Congress Calendar
https://doi.org/10.1515/jpm.2011.013
Keywords for this article
Appropriate for gestational age; fetal growth restriction; intrauterine growth restriction; small for gestational age; twins

Articles in the same Issue

  1. Publisher’s Note
  2. Publisher’s Note
  3. EDITORIAL
  4. Problems in prevention of preterm birth – regrettable contradictions
  5. REVIEW ARTICLES
  6. Listeriosis in human pregnancy: a systematic review
  7. Prevention of prematurity by single embryo transfer
  8. ORIGINAL ARTICLES - OBSTETRICS
  9. Effect of prior cesarean delivery on neonatal outcomes
  10. Amniotic lamellar body counts can predict the occurrence of respiratory distress syndrome as well as transient tachypnea of the newborn (TTN)
  11. Spectrum of cardiovascular findings during pregnancy and parturition at a tertiary referral center
  12. Risk groups and maternal-neonatal complications of preeclampsia – Current results from the national German Perinatal Quality Registry
  13. miRNA expression profiling in formalin-fixed and paraffin-embedded placental tissue samples from pregnancies with severe preeclampsia
  14. Genetic polymorphisms of killer cell immunoglobulin-like receptor 3DL2 in preeclampsia
  15. Addressing concerns about cisplatin application during pregnancy
  16. Retinol-binding protein-4 is decreased in patients with preeclampsia in comparison with normal pregnant women
  17. Somatic classification of neonates based on birth weight, length, and head circumference: quantification of the effects of maternal BMI and smoking
  18. Prediction of successful labor induction by evaluation of maternal symptoms at an early stage of the misoprostol induction protocol
  19. ORIGINAL ARTICLES - FETUS
  20. Increased nuchal translucency is associated with large for gestational age neonates in singleton pregnancies
  21. ORIGINAL ARTICLES - NEWBORN
  22. Predicting mortality in infants with persistent pulmonary hypertension of the newborn with the Score for Neonatal Acute Physiology-Version II (SNAP-II) in Thai neonates
  23. Neonatal outcome of preterm discordant twins
  24. Effects of delayed umbilical cord clamping on peripheral blood hematopoietic stem cells in premature neonates
  25. In utero exposure to Ureaplasma spp. is associated with increased rate of bronchopulmonary dysplasia and intraventricular hemorrhage in preterm infants
  26. Does prenatal antibiotic therapy compromise the diagnosis of early-onset infection and management of the neonate?
  27. SNAPPE-II application in newborns with very low birth weight: evaluation of adverse outcomes in severe placental dysfunction
  28. SHORT COMMUNICATION
  29. Lamellar bodies: platelet channel particles as predictors of respiratory distress syndrome (RDS) and of transient tachypnea of the newborn
  30. Intrahepatic and adrenal hemorrhage as a rare cause of neonatal anemia
  31. Subcutaneous fat distribution in small for gestational age newborns
  32. Calendar
  33. Congress Calendar
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