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Amniotic lamellar body counts can predict the occurrence of respiratory distress syndrome as well as transient tachypnea of the newborn (TTN)
-
Hiroyuki Tsuda
,
Yuichiro Takahashi
Published/Copyright:
February 11, 2011
Abstract
Aims: The purpose of this study is to predict the occurrence of transient tachypnea of the newborn (TTN) using amniotic lamellar body count (LBC) and compare the LBCs in neonates with TTN with the LBCs in neonates with respiratory distress syndrome (RDS) and controls.
Methods: Three hundred and eighty-one amniotic fluid samples were obtained at cesarean section from 27 to 40 weeks of gestation. Samples were analyzed immediately without centrifugation and the number of lamellar bodies was counted.
Results: The LBC in amniotic fluid ranged from 1,000 to 577,000/μL. An LBC cut-off value of 48,500/μL resulted in 84.7% sensitivity, 76.2% specificity, and 98.1% negative predictive value for predicting TTN. The LBC in neonates with TTN was significantly lower than that in controls (50,000 vs. 122,000; P<0.001) and significantly higher than that in neonates with RDS (50,000 vs. 21,000; P=0.042).
Conclusions: We established a cut-off value of LBC for predicting the occurrence of TTN. The LBC in neonates with TTN was significantly lower than that in controls. Amniotic LBC can be a useful marker to predict if neonatal respiratory management is required.
Keywords: Amniotic fluid; cesarean section; lamellar body; respiratory distress syndrome; transient tachypnea of the newborn
Received: 2010-7-19
Revised: 2010-10-2
Accepted: 2010-10-21
Published Online: 2011-02-11
Published Online: 2011-02-11
Published in Print: 2011-05-01
©2011 by Walter de Gruyter Berlin New York
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Keywords for this article
Amniotic fluid;
cesarean section;
lamellar body;
respiratory distress syndrome;
transient tachypnea of the newborn
Articles in the same Issue
- Publisher’s Note
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- EDITORIAL
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- REVIEW ARTICLES
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- Prevention of prematurity by single embryo transfer
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- Effects of delayed umbilical cord clamping on peripheral blood hematopoietic stem cells in premature neonates
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- Does prenatal antibiotic therapy compromise the diagnosis of early-onset infection and management of the neonate?
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