Addressing concerns about cisplatin application during pregnancy
-
Malgorzata Lanowska
,
Christhardt Köhler
Abstract
Introduction: Cervical cancer in second trimester of pregnancy is an oncologic challenge. Cisplatin is recommended to prevent cancer progression. This is a series correlating invivo cisplatin concentration in the fetomaternal compartment and in breast milk with child development.
Methods: Eight consecutive patients with cervical cancer diagnosed during the second trimester underwent conization/biopsy and/or pelvic laparoscopic lymphadenectomy (LAE). Delay of pregnancy in combination with neoadjuvant monochemotherapy was performed. After 2–4 cycles of cisplatin monochemotherapy cesarean section followed by radical hysterectomy was performed above 31 weeks of gestation. Synchronous samples from maternal blood, umbilical cord blood, and amniotic fluid were taken and analyzed. A probe of breast milk was taken from three patients. Pediatric aftercare was done every three months postpartum.
Results: Laparoscopic LAE was uncomplicated in all patients. In seven out of eight patients lymph nodes were tumor free. Nine healthy babies were delivered. Pediatric follow-up showed normal development. Cisplatin concentrations in the umbilical cord and amniotic fluid were 31–65% and 13–42% of the amount in maternal blood, respectively. In breast milk, cisplatin was detectable in 1–10% of maternal blood concentration.
Conclusion: Knowledge of significant lower cisplatin concentrations in fetal compartment and normal child growth provides additional security to apply cisplatin in pregnancy. Breastfeeding cannot be recommended.
©2011 by Walter de Gruyter Berlin New York
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- Calendar
- Congress Calendar
Articles in the same Issue
- Publisher’s Note
- Publisher’s Note
- EDITORIAL
- Problems in prevention of preterm birth – regrettable contradictions
- REVIEW ARTICLES
- Listeriosis in human pregnancy: a systematic review
- Prevention of prematurity by single embryo transfer
- ORIGINAL ARTICLES - OBSTETRICS
- Effect of prior cesarean delivery on neonatal outcomes
- Amniotic lamellar body counts can predict the occurrence of respiratory distress syndrome as well as transient tachypnea of the newborn (TTN)
- Spectrum of cardiovascular findings during pregnancy and parturition at a tertiary referral center
- Risk groups and maternal-neonatal complications of preeclampsia – Current results from the national German Perinatal Quality Registry
- miRNA expression profiling in formalin-fixed and paraffin-embedded placental tissue samples from pregnancies with severe preeclampsia
- Genetic polymorphisms of killer cell immunoglobulin-like receptor 3DL2 in preeclampsia
- Addressing concerns about cisplatin application during pregnancy
- Retinol-binding protein-4 is decreased in patients with preeclampsia in comparison with normal pregnant women
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- ORIGINAL ARTICLES - FETUS
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- Predicting mortality in infants with persistent pulmonary hypertension of the newborn with the Score for Neonatal Acute Physiology-Version II (SNAP-II) in Thai neonates
- Neonatal outcome of preterm discordant twins
- Effects of delayed umbilical cord clamping on peripheral blood hematopoietic stem cells in premature neonates
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- Does prenatal antibiotic therapy compromise the diagnosis of early-onset infection and management of the neonate?
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- SHORT COMMUNICATION
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- Intrahepatic and adrenal hemorrhage as a rare cause of neonatal anemia
- Subcutaneous fat distribution in small for gestational age newborns
- Calendar
- Congress Calendar
