Genetic polymorphisms of killer cell immunoglobulin-like receptor 3DL2 in preeclampsia
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Xiao-lan Wang
Abstract
Aims: We evaluated if killer cell immunoglobulin-like receptor 3DL2 gene (KIR3DL2) polymorphisms are a key factor in the development of preeclampsia.
Methods: In this case-control study, 105 pregnant women with PE (PE group) were enrolled. Their A52G in exon 3 and C32T in exon 9 polymorphisms of the KIR3DL2 genotypes were determined by polymorphism chain reaction-restriction fragment length polymorphism (PCR-RFLP) from venous blood samples and compared with the corresponding KIR3DL2 genotypes of 103 pregnant women with uncomplicated pregnancies (control group).
Results: Carriers of the A allele in exon 3 of KIR3DL2 gene occurred less frequently in PE than in controls [P=0.001; odds ratio (OR)=2.65, range: 1.5–4.7]. No significant difference was found about allelic frequencies of KIR3DL2 gene C32T in exon 9 in women with preeclampsia as compared to controls. A significant difference between the two groups of genotypic frequencies of KIR3DL2 gene A52G in exon 3 and KIR3DL2 gene C32T in exon 9 polymorphisms was found (P=0.003 and P=0.000). There was no significant difference between genotypic or allelic frequencies in women with mild preeclampsia compared to sever preeclampsia.
Conclusions: Our results suggest that carriers of A allele in exon 3 have a decreased susceptibility to PE. It is likely that the presence of the CC genotype in exon 9 has a considerable effect on disease progression. The mutation of the two sites is not associated with the severity of preeclampsia.
©2011 by Walter de Gruyter Berlin New York
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- Calendar
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Articles in the same Issue
- Publisher’s Note
- Publisher’s Note
- EDITORIAL
- Problems in prevention of preterm birth – regrettable contradictions
- REVIEW ARTICLES
- Listeriosis in human pregnancy: a systematic review
- Prevention of prematurity by single embryo transfer
- ORIGINAL ARTICLES - OBSTETRICS
- Effect of prior cesarean delivery on neonatal outcomes
- Amniotic lamellar body counts can predict the occurrence of respiratory distress syndrome as well as transient tachypnea of the newborn (TTN)
- Spectrum of cardiovascular findings during pregnancy and parturition at a tertiary referral center
- Risk groups and maternal-neonatal complications of preeclampsia – Current results from the national German Perinatal Quality Registry
- miRNA expression profiling in formalin-fixed and paraffin-embedded placental tissue samples from pregnancies with severe preeclampsia
- Genetic polymorphisms of killer cell immunoglobulin-like receptor 3DL2 in preeclampsia
- Addressing concerns about cisplatin application during pregnancy
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- Neonatal outcome of preterm discordant twins
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- Does prenatal antibiotic therapy compromise the diagnosis of early-onset infection and management of the neonate?
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