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Retinol-binding protein-4 is decreased in patients with preeclampsia in comparison with normal pregnant women

  • Hyun-Joo Seol , Jae-Won Kim and Hai-Joong Kim EMAIL logo
Published/Copyright: February 7, 2011
Journal of Perinatal Medicine
From the journal Volume 39 Issue 3

Abstract

Aims: The aim of this study was to investigate retinol-binding protein-4 (RBP4) levels in maternal and umbilical cord serum in patients in the third trimester of pregnancy with preeclampsia in comparison to levels in normal pregnant women.

Methods: The RBP4 levels in maternal and umbilical cord serum were measured and compared by enzyme-linked immunosorbent assay in 16 normal pregnant and 16 patients with preeclampsia.

Results: Both maternal and umbilical cord serum RBP4 levels were significantly decreased in patients with preeclampsia, as compared to normal pregnant women (maternal serum, median 168.0 μg/mL vs. 202.0 μg/mL, P<0.001; umbilical cord serum, median 147.9 μg/mL vs. 193.0 μg/mL, P<0.001). Preeclampsia was independently related to RBP4 levels of maternal and umbilical cord serum.

Conclusion: Both maternal and umbilical cord serum RBP4 levels were lower in patients with preeclampsia than in normal pregnant women in the third trimester of pregnancy.


Corresponding author: Hai-Joong Kim, MD Department of Obstetrics and Gynecology Korea University Ansan Hospital 516, Gojan-dong, Danwon-gu, Ansan-si Gyeonggi-do 425-707 Korea Tel.: +82-31-412-4800 Fax: +82-31-412-4202

Received: 2010-6-11
Revised: 2010-10-24
Accepted: 2010-11-22
Published Online: 2011-02-07
Published Online: 2011-02-07
Published in Print: 2011-05-01

©2011 by Walter de Gruyter Berlin New York

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