Induction and Regulation of Endogenous Granulocyte Colony-Stimulating Factor Formation
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L. Hareng
Abstract
Granulocyte colonystimulating factor (GCSF) is one of the most prominent endogenous proteins in broad clinical use. While its biological and clinical effects are relatively well studied, little is known about its endogenous formation in health and disease. However, such knowledge is crucial to decide in which situations GCSF should be applied efficiently in the clinic, i.e. when endogenous production does not suffice. The dramatic changes induced by GCSF in the differential blood cell count are directly immunomodulatory, strengthening the innate defence by multiplying neutrophilic granulocytes. A multitude of further immunomodulatory effects contribute to the regulation of the concerted host defence. In this review, following a short introduction into the biology of GCSF, the available data on endogenous formation in a number of animal models and human diseases is compiled. The cellular sources and inducers of GCSF formation are reviewed and the regulation of GCSF expression on both the transcriptional and translational level are discussed. The emerging understanding of the role and regulation of endogenous GCSF formation opens up possibilities to define therapeutic windows as well as targets for diagnostics or drug development. Lastly, the modulation of GCSF formation by various pharmacological agents alerts to putative side effects of these drug treatments.
Copyright © 2002 by Walter de Gruyter GmbH & Co. KG
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- Kai Simons Felix Hoppe-Seyler Lecturer 2002
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