RNA-Mediated RNA Degradation in Transgene- and Virus-Induced Gene Silencing
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M. Metzlaff
Abstract
In the RNA world hypothesis it is postulated that RNA was the first genetic molecule. Recent discoveries in gene silencing research on plants, fungi and animals show that RNA indeed plays a key role not only in controlling invading nucleic acids, like viruses and transposable elements, but also in regulating the expression of transgenes and endogenous genes. Doublestranded RNAs were identified to be the triggering structures for the induction of a specific and highly efficient RNA silencing system, in which enzyme complexes, like Dicer and RISC, facilitate as molecular machines the processing of dsRNA into characteristic small RNA species. RNA silencing can be transmitted rapidly from silenced to nonsilenced cells by short and long distance signaling. There is evidence that at least one component of the signal is a specific, degradationresistant RNA.
Copyright © 2002 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Biological Chemistry 125th Anniversary
- Kai Simons Felix Hoppe-Seyler Lecturer 2002
- Lipid Rafts in Protein Sorting and Cell Polarity in Budding Yeast Saccharomyces cerevisiae
- Paper of the Year 2001
- RNA-Mediated RNA Degradation in Transgene- and Virus-Induced Gene Silencing
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- The Human Steroid Hydroxylases CYP11B1 and CYP11B2
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- The Hyaluronan-Binding Serine Protease from Human Plasma Cleaves HMW and LMW Kininogen and Releases Bradykinin
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